FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201331497> ?p ?o ?g. }

• W3201331497 endingPage "1285" @default.
• W3201331497 startingPage "1274" @default.
• W3201331497 abstract "Rationale: Two distinct subphenotypes have been identified in acute respiratory distress syndrome (ARDS), but the presence of subgroups in ARDS associated with coronavirus disease (COVID-19) is unknown. Objectives: To identify clinically relevant, novel subgroups in COVID-19-related ARDS and compare them with previously described ARDS subphenotypes. Methods: Eligible participants were adults with COVID-19 and ARDS at Columbia University Irving Medical Center. Latent class analysis was used to identify subgroups with baseline clinical, respiratory, and laboratory data serving as partitioning variables. A previously developed machine learning model was used to classify patients as the hypoinflammatory and hyperinflammatory subphenotypes. Baseline characteristics and clinical outcomes were compared between subgroups. Heterogeneity of treatment effect for corticosteroid use in subgroups was tested. Measurements and Main Results: From March 2, 2020, to April 30, 2020, 483 patients with COVID-19-related ARDS met study criteria. A two-class latent class analysis model best fit the population (P = 0.0075). Class 2 (23%) had higher proinflammatory markers, troponin, creatinine, and lactate, lower bicarbonate, and lower blood pressure than class 1 (77%). Ninety-day mortality was higher in class 2 versus class 1 (75% vs. 48%; P < 0.0001). Considerable overlap was observed between these subgroups and ARDS subphenotypes. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RT-PCR cycle threshold was associated with mortality in the hypoinflammatory but not the hyperinflammatory phenotype. Heterogeneity of treatment effect to corticosteroids was observed (P = 0.0295), with improved mortality in the hyperinflammatory phenotype and worse mortality in the hypoinflammatory phenotype, with the caveat that corticosteroid treatment was not randomized. Conclusions: We identified two COVID-19-related ARDS subgroups with differential outcomes, similar to previously described ARDS subphenotypes. SARS-CoV-2 PCR cycle threshold had differential value for predicting mortality in the subphenotypes. The subphenotypes had differential treatment responses to corticosteroids." @default.
• W3201331497 created "2021-09-27" @default.
• W3201331497 creator A5007130934 @default.
• W3201331497 creator A5012057955 @default.
• W3201331497 creator A5014682392 @default.
• W3201331497 creator A5018663716 @default.
• W3201331497 creator A5025222606 @default.
• W3201331497 creator A5025668325 @default.
• W3201331497 creator A5027065226 @default.
• W3201331497 creator A5028046556 @default.
• W3201331497 creator A5029316781 @default.
• W3201331497 creator A5032803891 @default.
• W3201331497 creator A5039858794 @default.
• W3201331497 creator A5041459074 @default.
• W3201331497 creator A5048929851 @default.
• W3201331497 creator A5051494461 @default.
• W3201331497 creator A5057635403 @default.
• W3201331497 creator A5061093871 @default.
• W3201331497 creator A5062212651 @default.
• W3201331497 creator A5077448494 @default.
• W3201331497 creator A5077468662 @default.
• W3201331497 creator A5077923202 @default.
• W3201331497 creator A5078371593 @default.
• W3201331497 creator A5080853570 @default.
• W3201331497 creator A5084612869 @default.
• W3201331497 creator A5086221595 @default.
• W3201331497 creator A5088626358 @default.
• W3201331497 date "2021-12-01" @default.
• W3201331497 modified "2023-10-16" @default.
• W3201331497 title "Latent Class Analysis Reveals COVID-19–related Acute Respiratory Distress Syndrome Subgroups with Differential Responses to Corticosteroids" @default.
• W3201331497 cites W1803784511 @default.
• W3201331497 cites W1995121548 @default.
• W3201331497 cites W2124519382 @default.
• W3201331497 cites W2144674187 @default.
• W3201331497 cites W2286228001 @default.
• W3201331497 cites W2515625652 @default.
• W3201331497 cites W2620241325 @default.
• W3201331497 cites W2769689735 @default.
• W3201331497 cites W2885500852 @default.
• W3201331497 cites W2889601329 @default.
• W3201331497 cites W2894810674 @default.
• W3201331497 cites W2904268023 @default.
• W3201331497 cites W2998886261 @default.
• W3201331497 cites W3008090866 @default.
• W3201331497 cites W3012923578 @default.
• W3201331497 cites W3014294089 @default.
• W3201331497 cites W3020655133 @default.
• W3201331497 cites W3024193040 @default.
• W3201331497 cites W3027401801 @default.
• W3201331497 cites W3029656471 @default.
• W3201331497 cites W3034858522 @default.
• W3201331497 cites W3036339803 @default.
• W3201331497 cites W3039623205 @default.
• W3201331497 cites W3045700899 @default.
• W3201331497 cites W3046994873 @default.
• W3201331497 cites W3047719754 @default.
• W3201331497 cites W3048601848 @default.
• W3201331497 cites W3081015435 @default.
• W3201331497 cites W3081721922 @default.
• W3201331497 cites W3081877184 @default.
• W3201331497 cites W3082108964 @default.
• W3201331497 cites W3082355253 @default.
• W3201331497 cites W3082720169 @default.
• W3201331497 cites W3096704753 @default.
• W3201331497 cites W3102547229 @default.
• W3201331497 cites W3125996955 @default.
• W3201331497 cites W3130126061 @default.
• W3201331497 cites W3131781727 @default.
• W3201331497 cites W3154598968 @default.
• W3201331497 cites W3160337168 @default.
• W3201331497 cites W3160842620 @default.
• W3201331497 cites W3162199380 @default.
• W3201331497 cites W3165428930 @default.
• W3201331497 cites W3178523294 @default.
• W3201331497 cites W3181737900 @default.
• W3201331497 cites W4206449744 @default.
• W3201331497 cites W4210642183 @default.
• W3201331497 doi "https://doi.org/10.1164/rccm.202105-1302oc" @default.
• W3201331497 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34543591" @default.
• W3201331497 hasPublicationYear "2021" @default.
• W3201331497 type Work @default.
• W3201331497 sameAs 3201331497 @default.
• W3201331497 citedByCount "90" @default.
• W3201331497 countsByYear W32013314972021 @default.
• W3201331497 countsByYear W32013314972022 @default.
• W3201331497 countsByYear W32013314972023 @default.
• W3201331497 crossrefType "journal-article" @default.
• W3201331497 hasAuthorship W3201331497A5007130934 @default.
• W3201331497 hasAuthorship W3201331497A5012057955 @default.
• W3201331497 hasAuthorship W3201331497A5014682392 @default.
• W3201331497 hasAuthorship W3201331497A5018663716 @default.
• W3201331497 hasAuthorship W3201331497A5025222606 @default.
• W3201331497 hasAuthorship W3201331497A5025668325 @default.
• W3201331497 hasAuthorship W3201331497A5027065226 @default.
• W3201331497 hasAuthorship W3201331497A5028046556 @default.
• W3201331497 hasAuthorship W3201331497A5029316781 @default.
• W3201331497 hasAuthorship W3201331497A5032803891 @default.
• W3201331497 hasAuthorship W3201331497A5039858794 @default.

• next