FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201335144> ?p ?o ?g. }

• W3201335144 abstract "BACKGROUND AND AIM AND HYPOTHESIS: BDNF, FGF2 and NGF are neurotrophins associated with neuroplasticity, nervous system development and psychiatric disorder in the literature. BDNF in particular is suggested as a useful biomarker of mood disorder. Both mindfulness and physical activity are shown to improve mood, reduce stress and are widely used as part of a multi-component treatment approach, reducing distressing symptoms of mood and affect disorders. The utility of protein level as a biomarker has been controversial in the literature following issues concerning the assessment of peripheral levels as a proxy for central levels. The principal aim of this study was to investigate the gene expression of three neurotrophins BDNF, FGF2 and NGF as potential biomarkers of mood disorder, at an early stage of these disorders, which are now widely recognised as having pathogenesis related to dysregulation in the neuro-immuno-endocrine axis. In addition, the study will explore the effect of both physical activity and mindfulness on neurotrophin expression clarifying the associations between the success of these interventions seen in the literature and their effect on the change of neurotrophin expression. Current literature reports increased levels of BDNF protein both centrally and peripherally following mood disorder treatment and participation in both physical exercise and mindfulness activities. Based on similarity of structure and function amongst the three neurotrophins, this thesis will hypothesize an increase in BDNF and potentially FGF2 and NGF mRNA following participation in the two interventional modules designed to improve wellbeing in clinical and non-clinical communities. METHOD: In this independent measures design, 28 non-clinical volunteers were randomly allocated to an 8 week intervention, comprising digital health tracking modules and participation in an unstructured increase in Physical Activity or Mindfulness program, to assess the effect of these interventions on levels of mRNA expression. RTqPCR was used to compare relative mRNA abundance in peripheral blood at baseline and 8 week time interval. The control group were allocated to a waitlist for the period of the 8 week study, followed by access to the program of their choice. Change in emotional state was measured using the DASS. RESULT: BDNF expression is shown significantly increased (p 0.01, n=5) in the Physical Activity group, and significantly decreased in the Mindfulness group (p 0.01, n=11). FGF2 and waitlisted controls showed no significant change. In the case of NGF no expression was seen in human peripheral blood either before or after the intervention. DASS scores revealed a significant decrease in negative affect in the Mindfulness group p = 0.03. CONCLUSION: This study revealed a significant positive association between physical activity and BDNF mRNA, although no significant reduction in distressing mood symptoms was shown. This was potentially due to the small group size. Mindfulness was significantly associated with decreasing negative…" @default.
• W3201335144 created "2021-09-27" @default.
• W3201335144 creator A5011114346 @default.
• W3201335144 date "2017-01-01" @default.
• W3201335144 modified "2023-09-27" @default.
• W3201335144 title "Neurotrophic biomarker change after physical activity and mindfulness interventions" @default.
• W3201335144 hasPublicationYear "2017" @default.
• W3201335144 type Work @default.
• W3201335144 sameAs 3201335144 @default.
• W3201335144 citedByCount "0" @default.
• W3201335144 crossrefType "journal-article" @default.
• W3201335144 hasAuthorship W3201335144A5011114346 @default.
• W3201335144 hasConcept C118552586 @default.
• W3201335144 hasConcept C126322002 @default.
• W3201335144 hasConcept C15744967 @default.
• W3201335144 hasConcept C160539049 @default.
• W3201335144 hasConcept C169760540 @default.
• W3201335144 hasConcept C170493617 @default.
• W3201335144 hasConcept C2777134132 @default.
• W3201335144 hasConcept C2780444219 @default.
• W3201335144 hasConcept C2780733359 @default.
• W3201335144 hasConcept C2781197716 @default.
• W3201335144 hasConcept C47611674 @default.
• W3201335144 hasConcept C55493867 @default.
• W3201335144 hasConcept C558461103 @default.
• W3201335144 hasConcept C70410870 @default.
• W3201335144 hasConcept C71924100 @default.
• W3201335144 hasConcept C86803240 @default.
• W3201335144 hasConcept C92020748 @default.
• W3201335144 hasConceptScore W3201335144C118552586 @default.
• W3201335144 hasConceptScore W3201335144C126322002 @default.
• W3201335144 hasConceptScore W3201335144C15744967 @default.
• W3201335144 hasConceptScore W3201335144C160539049 @default.
• W3201335144 hasConceptScore W3201335144C169760540 @default.
• W3201335144 hasConceptScore W3201335144C170493617 @default.
• W3201335144 hasConceptScore W3201335144C2777134132 @default.
• W3201335144 hasConceptScore W3201335144C2780444219 @default.
• W3201335144 hasConceptScore W3201335144C2780733359 @default.
• W3201335144 hasConceptScore W3201335144C2781197716 @default.
• W3201335144 hasConceptScore W3201335144C47611674 @default.
• W3201335144 hasConceptScore W3201335144C55493867 @default.
• W3201335144 hasConceptScore W3201335144C558461103 @default.
• W3201335144 hasConceptScore W3201335144C70410870 @default.
• W3201335144 hasConceptScore W3201335144C71924100 @default.
• W3201335144 hasConceptScore W3201335144C86803240 @default.
• W3201335144 hasConceptScore W3201335144C92020748 @default.
• W3201335144 hasLocation W32013351441 @default.
• W3201335144 hasOpenAccess W3201335144 @default.
• W3201335144 hasPrimaryLocation W32013351441 @default.
• W3201335144 hasRelatedWork W1492555131 @default.
• W3201335144 hasRelatedWork W1574023083 @default.
• W3201335144 hasRelatedWork W195360190 @default.
• W3201335144 hasRelatedWork W1973652904 @default.
• W3201335144 hasRelatedWork W2011585955 @default.
• W3201335144 hasRelatedWork W2043283741 @default.
• W3201335144 hasRelatedWork W2132244655 @default.
• W3201335144 hasRelatedWork W2329338014 @default.
• W3201335144 hasRelatedWork W2470432065 @default.
• W3201335144 hasRelatedWork W2551842538 @default.
• W3201335144 hasRelatedWork W2613899541 @default.
• W3201335144 hasRelatedWork W2776944786 @default.
• W3201335144 hasRelatedWork W2890069787 @default.
• W3201335144 hasRelatedWork W2896160894 @default.
• W3201335144 hasRelatedWork W2916807146 @default.
• W3201335144 hasRelatedWork W2937865811 @default.
• W3201335144 hasRelatedWork W3004456853 @default.
• W3201335144 hasRelatedWork W3048732424 @default.
• W3201335144 hasRelatedWork W3120024539 @default.
• W3201335144 hasRelatedWork W3190963756 @default.
• W3201335144 isParatext "false" @default.
• W3201335144 isRetracted "false" @default.
• W3201335144 magId "3201335144" @default.
• W3201335144 workType "article" @default.