Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201345145> ?p ?o ?g. }
- W3201345145 endingPage "109742" @default.
- W3201345145 startingPage "109742" @default.
- W3201345145 abstract "Cold-induced thermogenesis in endotherms demands adaptive thermogenesis fueled by mitochondrial respiration and Ucp1-mediated uncoupling in multilocular brown adipocytes (BAs). However, dietary regulation of thermogenesis in BAs isn't fully understood. Here, we describe that the deficiency of Leucine-rich pentatricopeptide repeat containing-protein (Lrpprc) in BAs reduces mtDNA-encoded ETC gene expression, causes ETC proteome imbalance, and abolishes the mitochondria-fueled thermogenesis. BA-specific Lrpprc knockout mice are cold resistant in a 4°C cold-tolerance test in the presence of food, which is accompanied by the activation of transcription factor 4 (ATF4) and proteome turnover in BAs. ATF4 activation genetically by BA-specific ATF4 overexpression or physiologically by a low-protein diet feeding can improve cold tolerance in wild-type and Ucp1 knockout mice. Furthermore, ATF4 activation in BAs improves systemic metabolism in obesogenic environment regardless of Ucp1's action. Therefore, our study reveals a diet-dependent but Ucp1-independent thermogenic mechanism in BAs that is relevant to systemic thermoregulation and energy homeostasis." @default.
- W3201345145 created "2021-09-27" @default.
- W3201345145 creator A5023874610 @default.
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- W3201345145 creator A5087550248 @default.
- W3201345145 date "2021-09-01" @default.
- W3201345145 modified "2023-10-16" @default.
- W3201345145 title "Brown adipocyte ATF4 activation improves thermoregulation and systemic metabolism" @default.
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