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- W3201346265 abstract "Autism spectrum disorder (ASD) is a multifactorial disorder with characteristic synaptic and gene expression changes. Early intervention during childhood is thought to benefit prognosis. Here, we examined the changes in cortical synaptogenesis, synaptic function, and gene expression from birth to the juvenile stage in a marmoset model of ASD induced by valproic acid (VPA) treatment. Early postnatally, synaptogenesis was reduced in this model, while juvenile-age VPA-treated marmosets showed increased synaptogenesis, similar to observations in human tissue. During infancy, synaptic plasticity transiently increased and was associated with altered vocalization. Synaptogenesis-related genes were downregulated early postnatally. At three months of age, the differentially expressed genes were associated with circuit remodeling, similar to the expression changes observed in humans. In summary, we provide a functional and molecular characterization of a non-human primate model of ASD, highlighting its similarity to features observed in human ASD." @default.
- W3201346265 created "2021-09-27" @default.
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- W3201346265 date "2021-09-15" @default.
- W3201346265 modified "2023-10-15" @default.
- W3201346265 title "Functional and molecular characterization of a non-human primate model of autism spectrum disorder shows similarity with the human disease" @default.
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- W3201346265 doi "https://doi.org/10.1038/s41467-021-25487-6" @default.
- W3201346265 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8443557" @default.
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- W3201346265 hasPublicationYear "2021" @default.
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