Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201347380> ?p ?o ?g. }
- W3201347380 abstract "Statins are widely used to manage hypercholesterolemia, and clinical trials have demonstrated that statins as monotherapies are effective anticancer agents in some patients. We aim to identify combination treatments that will expand the anticancer benefit of statins. We hypothesize that screening cancer cell lines with a genomic shRNA library and a small-molecule library will identify novel compounds to use in co-therapies with fluvastatin. A pooled shRNA dropout screen was performed to find genomic targets to inhibit alongside fluvastatin, which revealed several kinase targets as dropouts. This suggested that knocking down specific kinases can potentiate fluvastatin-induced cell death. To identify known kinase inhibitors that interact with fluvastatin to elicit cancer cell kill, we screened with a library of 320 kinase inhibitors, which revealed several putative hits. We anticipate that continued validation of candidates from both screens will lead to the identification of novel anticancer statin-based drug cocktails.%%%%MAST" @default.
- W3201347380 created "2021-09-27" @default.
- W3201347380 creator A5032651175 @default.
- W3201347380 date "2014-01-01" @default.
- W3201347380 modified "2023-09-27" @default.
- W3201347380 title "Cross-platform Screening for Novel Fluvastatin and Kinase Inhibitor Co-therapies in Cancer Cell Lines" @default.
- W3201347380 cites W1581824937 @default.
- W3201347380 cites W1639366885 @default.
- W3201347380 cites W1849021584 @default.
- W3201347380 cites W1896854564 @default.
- W3201347380 cites W1970090817 @default.
- W3201347380 cites W1971013239 @default.
- W3201347380 cites W1972665180 @default.
- W3201347380 cites W1980039397 @default.
- W3201347380 cites W1983592978 @default.
- W3201347380 cites W1987691057 @default.
- W3201347380 cites W1990388569 @default.
- W3201347380 cites W1992356221 @default.
- W3201347380 cites W1996729627 @default.
- W3201347380 cites W1998971866 @default.
- W3201347380 cites W1999614615 @default.
- W3201347380 cites W2005895632 @default.
- W3201347380 cites W2009931781 @default.
- W3201347380 cites W2013114408 @default.
- W3201347380 cites W2018593069 @default.
- W3201347380 cites W2022532937 @default.
- W3201347380 cites W2026048257 @default.
- W3201347380 cites W2030205108 @default.
- W3201347380 cites W2034269086 @default.
- W3201347380 cites W2035401368 @default.
- W3201347380 cites W2039049403 @default.
- W3201347380 cites W2039999119 @default.
- W3201347380 cites W2043263931 @default.
- W3201347380 cites W2047594294 @default.
- W3201347380 cites W2059300459 @default.
- W3201347380 cites W2065276754 @default.
- W3201347380 cites W2067020827 @default.
- W3201347380 cites W2069708743 @default.
- W3201347380 cites W2070244957 @default.
- W3201347380 cites W2071124826 @default.
- W3201347380 cites W2077804275 @default.
- W3201347380 cites W2083750996 @default.
- W3201347380 cites W2090144921 @default.
- W3201347380 cites W2091005492 @default.
- W3201347380 cites W2096521047 @default.
- W3201347380 cites W2096931514 @default.
- W3201347380 cites W2100195364 @default.
- W3201347380 cites W2101537043 @default.
- W3201347380 cites W2107841008 @default.
- W3201347380 cites W2108069034 @default.
- W3201347380 cites W2113649367 @default.
- W3201347380 cites W2117692326 @default.
- W3201347380 cites W2118217667 @default.
- W3201347380 cites W2119460950 @default.
- W3201347380 cites W2123879591 @default.
- W3201347380 cites W2124593509 @default.
- W3201347380 cites W2126903025 @default.
- W3201347380 cites W2133488997 @default.
- W3201347380 cites W2133528707 @default.
- W3201347380 cites W2135250565 @default.
- W3201347380 cites W2135630936 @default.
- W3201347380 cites W2140334822 @default.
- W3201347380 cites W2147699387 @default.
- W3201347380 cites W2148463229 @default.
- W3201347380 cites W2150144117 @default.
- W3201347380 cites W2151041593 @default.
- W3201347380 cites W2152781694 @default.
- W3201347380 cites W2161815151 @default.
- W3201347380 cites W2161821474 @default.
- W3201347380 cites W2163018106 @default.
- W3201347380 cites W2167737594 @default.
- W3201347380 cites W2318605753 @default.
- W3201347380 cites W2334674063 @default.
- W3201347380 hasPublicationYear "2014" @default.
- W3201347380 type Work @default.
- W3201347380 sameAs 3201347380 @default.
- W3201347380 citedByCount "0" @default.
- W3201347380 crossrefType "journal-article" @default.
- W3201347380 hasAuthorship W3201347380A5032651175 @default.
- W3201347380 hasConcept C103637391 @default.
- W3201347380 hasConcept C121608353 @default.
- W3201347380 hasConcept C126322002 @default.
- W3201347380 hasConcept C173396325 @default.
- W3201347380 hasConcept C184235292 @default.
- W3201347380 hasConcept C185592680 @default.
- W3201347380 hasConcept C190232843 @default.
- W3201347380 hasConcept C2776329913 @default.
- W3201347380 hasConcept C2776839432 @default.
- W3201347380 hasConcept C2778417548 @default.
- W3201347380 hasConcept C2780035454 @default.
- W3201347380 hasConcept C2780808130 @default.
- W3201347380 hasConcept C29537977 @default.
- W3201347380 hasConcept C502942594 @default.
- W3201347380 hasConcept C54355233 @default.
- W3201347380 hasConcept C55493867 @default.
- W3201347380 hasConcept C60644358 @default.
- W3201347380 hasConcept C71924100 @default.
- W3201347380 hasConcept C74187038 @default.
- W3201347380 hasConcept C81885089 @default.
- W3201347380 hasConcept C86803240 @default.