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- W3201349726 endingPage "10676" @default.
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- W3201349726 abstract "Epstein-Barr virus (EBV) is a human herpesvirus associated with human cancers worldwide. Ex vivo, the virus efficiently infects resting human B lymphocytes and induces their continuous proliferation. This process is accompanied by a global reprogramming of cellular gene transcription. However, very little is known on the impact of EBV infection on the regulation of alternative splicing, a pivotal mechanism that plays an essential role in cell fate determination and is often deregulated in cancer. In this study, we have developed a systematic time-resolved analysis of cellular mRNA splice variant expression during EBV infection of resting B lymphocytes. Our results reveal that major modifications of alternative splice variant expression appear as early as day 1 post-infection and suggest that splicing regulation provides-besides transcription-an additional mechanism of gene expression regulation at the onset of B cell activation and proliferation. We also report a role for the viral proteins, EBNA2 and EBNA-LP, in the modulation of specific alternative splicing events and reveal a previously unknown function for EBNA-LP-together with the RBM4 splicing factor-in the alternative splicing regulation of two important modulators of cell proliferation and apoptosis respectively, NUMB and BCL-X." @default.
- W3201349726 created "2021-09-27" @default.
- W3201349726 creator A5007840216 @default.
- W3201349726 creator A5037072527 @default.
- W3201349726 creator A5052854532 @default.
- W3201349726 creator A5076709957 @default.
- W3201349726 creator A5077481610 @default.
- W3201349726 creator A5084800206 @default.
- W3201349726 creator A5090277402 @default.
- W3201349726 creator A5090866168 @default.
- W3201349726 date "2021-09-16" @default.
- W3201349726 modified "2023-10-18" @default.
- W3201349726 title "Modulation of alternative splicing during early infection of human primary B lymphocytes with Epstein-Barr virus (EBV): a novel function for the viral EBNA-LP protein" @default.
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