FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201377577> ?p ?o ?g. }

• W3201377577 endingPage "4704" @default.
• W3201377577 startingPage "4704" @default.
• W3201377577 abstract "Sarcomas are a diverse group of bone and soft tissue tumors that account for over 10% of childhood cancers. Outcomes are particularly poor for children with refractory, relapsed, or metastatic disease. Chimeric antigen receptor T (CAR T) cells are an exciting form of adoptive cell therapy that potentially offers new hope for these children. In early trials, promising outcomes have been achieved in some pediatric patients with sarcoma. However, many children do not derive benefit despite significant expression of the targeted tumor antigen. The success of CAR T cell therapy in sarcomas and other solid tumors is limited by the immunosuppressive tumor microenvironment (TME). In this review, we provide an update of the CAR T cell therapies that are currently being tested in pediatric sarcoma clinical trials, including those targeting tumors that express HER2, NY-ESO, GD2, EGFR, GPC3, B7-H3, and MAGE-A4. We also outline promising new CAR T cells that are in pre-clinical development. Finally, we discuss strategies that are being used to overcome tumor-mediated immunosuppression in solid tumors; these strategies have the potential to improve clinical outcomes of CAR T cell therapy for children with sarcoma." @default.
• W3201377577 created "2021-09-27" @default.
• W3201377577 creator A5004235393 @default.
• W3201377577 creator A5029940736 @default.
• W3201377577 creator A5039295944 @default.
• W3201377577 creator A5043292171 @default.
• W3201377577 creator A5045195406 @default.
• W3201377577 creator A5046321083 @default.
• W3201377577 creator A5050455996 @default.
• W3201377577 creator A5053765299 @default.
• W3201377577 creator A5055053148 @default.
• W3201377577 creator A5072009574 @default.
• W3201377577 creator A5086201555 @default.
• W3201377577 creator A5086826224 @default.
• W3201377577 date "2021-09-20" @default.
• W3201377577 modified "2023-10-01" @default.
• W3201377577 title "Chimeric Antigen Receptor T cell Therapy and the Immunosuppressive Tumor Microenvironment in Pediatric Sarcoma" @default.
• W3201377577 cites W1558704041 @default.
• W3201377577 cites W1727290854 @default.
• W3201377577 cites W1758112907 @default.
• W3201377577 cites W1965030776 @default.
• W3201377577 cites W1967358904 @default.
• W3201377577 cites W1971518635 @default.
• W3201377577 cites W1981302308 @default.
• W3201377577 cites W1998120322 @default.
• W3201377577 cites W2003690177 @default.
• W3201377577 cites W2011028805 @default.
• W3201377577 cites W2011176154 @default.
• W3201377577 cites W2012495060 @default.
• W3201377577 cites W2018924811 @default.
• W3201377577 cites W2027863358 @default.
• W3201377577 cites W2038381158 @default.
• W3201377577 cites W2040159457 @default.
• W3201377577 cites W2054738595 @default.
• W3201377577 cites W2073449350 @default.
• W3201377577 cites W2074795010 @default.
• W3201377577 cites W2087979291 @default.
• W3201377577 cites W2094945699 @default.
• W3201377577 cites W2095599995 @default.
• W3201377577 cites W2108473659 @default.
• W3201377577 cites W2112680373 @default.
• W3201377577 cites W2127543830 @default.
• W3201377577 cites W2128125459 @default.
• W3201377577 cites W2132564070 @default.
• W3201377577 cites W2140821500 @default.
• W3201377577 cites W2153712501 @default.
• W3201377577 cites W2157255884 @default.
• W3201377577 cites W2162301936 @default.
• W3201377577 cites W2164559547 @default.
• W3201377577 cites W2165119413 @default.
• W3201377577 cites W2166037275 @default.
• W3201377577 cites W2259143846 @default.
• W3201377577 cites W2273004055 @default.
• W3201377577 cites W2276096997 @default.
• W3201377577 cites W2293645537 @default.
• W3201377577 cites W2428642147 @default.
• W3201377577 cites W2508616096 @default.
• W3201377577 cites W2520601585 @default.
• W3201377577 cites W2572286959 @default.
• W3201377577 cites W2604982880 @default.
• W3201377577 cites W2605654758 @default.
• W3201377577 cites W2624782256 @default.
• W3201377577 cites W2724923558 @default.
• W3201377577 cites W2734515449 @default.
• W3201377577 cites W2752414510 @default.
• W3201377577 cites W2759643796 @default.
• W3201377577 cites W2761586559 @default.
• W3201377577 cites W2768567700 @default.
• W3201377577 cites W2790555439 @default.
• W3201377577 cites W2792588868 @default.
• W3201377577 cites W2796821082 @default.
• W3201377577 cites W2802394123 @default.
• W3201377577 cites W2805860820 @default.
• W3201377577 cites W2807603420 @default.
• W3201377577 cites W2884560606 @default.
• W3201377577 cites W2885810871 @default.
• W3201377577 cites W2886360512 @default.
• W3201377577 cites W2888659925 @default.
• W3201377577 cites W2890875511 @default.
• W3201377577 cites W2891593192 @default.
• W3201377577 cites W2891825803 @default.
• W3201377577 cites W2896986869 @default.
• W3201377577 cites W2897752129 @default.
• W3201377577 cites W2901466105 @default.
• W3201377577 cites W2907564726 @default.
• W3201377577 cites W2910164268 @default.
• W3201377577 cites W2911543360 @default.
• W3201377577 cites W2916411715 @default.
• W3201377577 cites W2937806960 @default.
• W3201377577 cites W2953649002 @default.
• W3201377577 cites W2961879220 @default.
• W3201377577 cites W2971468927 @default.
• W3201377577 cites W2972844251 @default.
• W3201377577 cites W2974888135 @default.
• W3201377577 cites W2977427874 @default.
• W3201377577 cites W2981079812 @default.
• W3201377577 cites W2981595408 @default.
• W3201377577 cites W2989449197 @default.

• next