FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201387507> ?p ?o ?g. }

• W3201387507 abstract "Daidzein has been found to significantly inhibit the proliferation of lung cancer cells, while its potential molecular mechanisms remain unclear. To determine the molecular mechanism of daidzein on lung cancer cells, the Capital Bio Technology Human long non‑coding (lnc) RNA Array v4, 4x180K chip was used to detect the gene expression profiles of 40,000 lncRNAs and 34,000 mRNAs in a human cancer cell line. Reverse transcription‑quantitative (RT‑q) PCR analysis was performed to detect the expression levels of target lncRNA and mRNAs in the H1299 cells treated with and without daidzein, using the lncRNA and mRNA gene chip. Bioinformatics analysis was performed to determine the differentially expressed genes from the results of the chip assays. There were 119 and 40 differentially expressed lncRNAs and mRNAs, respectively, that had a 2‑fold change in expression level. A total of eight lncRNAs were upregulated in the H1299 lung cancer cells, while 111 lncRNAs were downregulated. Furthermore, five mRNAs were upregulated, and 35 mRNAs were downregulated. A total of six differentially expressed lncRNAs (ENST00000608897.1, ENST00000444196.1, ENST00000608741.1, XR_242163.1, ENST00000505196.1 and ENST00000498032.1) were randomly selected to validate the microarray data, which were consistent with the RT‑qPCR analysis results. Differentially expressed mRNAs were enriched in important Gene Ontology terms and Kyoto Encyclopedia of Genes and Genomes pathways. Taken together, the results of the present study demonstrated that daidzein affected the expression level of lncRNAs in lung cancer cells, suggesting that daidzein may have potential effects on lung cancer cells." @default.
• W3201387507 created "2021-09-27" @default.
• W3201387507 creator A5006822602 @default.
• W3201387507 creator A5010761268 @default.
• W3201387507 creator A5024849520 @default.
• W3201387507 creator A5027835055 @default.
• W3201387507 creator A5072453212 @default.
• W3201387507 creator A5078608735 @default.
• W3201387507 date "2021-09-17" @default.
• W3201387507 modified "2023-10-01" @default.
• W3201387507 title "Microarray analysis of differentially expressed long non‑coding RNAs in daidzein‑treated lung cancer cells" @default.
• W3201387507 cites W113889405 @default.
• W3201387507 cites W1546709038 @default.
• W3201387507 cites W1960573913 @default.
• W3201387507 cites W1966714489 @default.
• W3201387507 cites W1969331809 @default.
• W3201387507 cites W1979535902 @default.
• W3201387507 cites W1985749030 @default.
• W3201387507 cites W1987388559 @default.
• W3201387507 cites W1989734503 @default.
• W3201387507 cites W1993415234 @default.
• W3201387507 cites W2018502914 @default.
• W3201387507 cites W2029919331 @default.
• W3201387507 cites W2031205682 @default.
• W3201387507 cites W2032813428 @default.
• W3201387507 cites W2055217375 @default.
• W3201387507 cites W2056406047 @default.
• W3201387507 cites W2075556692 @default.
• W3201387507 cites W2088144811 @default.
• W3201387507 cites W2113778237 @default.
• W3201387507 cites W2116811581 @default.
• W3201387507 cites W2125548623 @default.
• W3201387507 cites W2126228623 @default.
• W3201387507 cites W2128983843 @default.
• W3201387507 cites W2146573461 @default.
• W3201387507 cites W2147114673 @default.
• W3201387507 cites W2150926065 @default.
• W3201387507 cites W2150993343 @default.
• W3201387507 cites W2178878860 @default.
• W3201387507 cites W2198863409 @default.
• W3201387507 cites W2220034225 @default.
• W3201387507 cites W2322485417 @default.
• W3201387507 cites W2463219782 @default.
• W3201387507 cites W2488616775 @default.
• W3201387507 cites W2554345814 @default.
• W3201387507 cites W2564436755 @default.
• W3201387507 cites W2587055213 @default.
• W3201387507 cites W2587125658 @default.
• W3201387507 cites W2594177343 @default.
• W3201387507 cites W2599238450 @default.
• W3201387507 cites W2622194495 @default.
• W3201387507 cites W2758499822 @default.
• W3201387507 cites W2767840752 @default.
• W3201387507 cites W2770595158 @default.
• W3201387507 cites W2772817669 @default.
• W3201387507 cites W2782008447 @default.
• W3201387507 cites W2789525724 @default.
• W3201387507 cites W2791846789 @default.
• W3201387507 cites W2795382323 @default.
• W3201387507 cites W2804027477 @default.
• W3201387507 cites W2810257140 @default.
• W3201387507 cites W2889438018 @default.
• W3201387507 cites W2895679848 @default.
• W3201387507 cites W2900943027 @default.
• W3201387507 cites W2911188335 @default.
• W3201387507 cites W2946520530 @default.
• W3201387507 cites W2949283626 @default.
• W3201387507 cites W2971126595 @default.
• W3201387507 cites W2989313910 @default.
• W3201387507 cites W2989686800 @default.
• W3201387507 cites W2990454547 @default.
• W3201387507 cites W3005022391 @default.
• W3201387507 cites W3006080599 @default.
• W3201387507 cites W3011999779 @default.
• W3201387507 cites W3034575867 @default.
• W3201387507 cites W3044144672 @default.
• W3201387507 cites W3089333865 @default.
• W3201387507 cites W329007366 @default.
• W3201387507 cites W657379961 @default.
• W3201387507 doi "https://doi.org/10.3892/ol.2021.13050" @default.
• W3201387507 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8488333" @default.
• W3201387507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34630702" @default.
• W3201387507 hasPublicationYear "2021" @default.
• W3201387507 type Work @default.
• W3201387507 sameAs 3201387507 @default.
• W3201387507 citedByCount "2" @default.
• W3201387507 countsByYear W32013875072022 @default.
• W3201387507 countsByYear W32013875072023 @default.
• W3201387507 crossrefType "journal-article" @default.
• W3201387507 hasAuthorship W3201387507A5006822602 @default.
• W3201387507 hasAuthorship W3201387507A5010761268 @default.
• W3201387507 hasAuthorship W3201387507A5024849520 @default.
• W3201387507 hasAuthorship W3201387507A5027835055 @default.
• W3201387507 hasAuthorship W3201387507A5072453212 @default.
• W3201387507 hasAuthorship W3201387507A5078608735 @default.
• W3201387507 hasBestOaLocation W32013875071 @default.
• W3201387507 hasConcept C104317684 @default.
• W3201387507 hasConcept C121608353 @default.
• W3201387507 hasConcept C127561419 @default.
• W3201387507 hasConcept C142724271 @default.

• next