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• W3201398410 abstract "Abstract Previous studies have shown that plasmablasts expand massively in dengue patients as compared to many other situations such as influenza infection or vaccination. However, a detailed understanding of the phenotypes and transcriptional features of these cells is lacking. Moreover, despite India having nearly a third of global dengue disease burden, there is virtually no information on plasmablasts responses in dengue patients from India. Here, we provide a detailed characterization of plasmablast responses from dengue confirmed febrile children in India. Immunophenotyping and RNA seq analysis showed that in addition to secreting dengue specific antibodies, these massively expanding cells expressed several adhesion molecules, chemokines and chemokine receptors that are involved in endothelial interactions, homing to skin or mucosal tissues including intestine. Surprisingly, we found that these cells also upregulated expression of several cytokine genes that are involved in angiogenesis, leukocyte extravasation and vascular permeability. These transcriptional features were qualitatively similar to plasmablasts from influenza vaccinees. Interestingly, the expansion of the plasmablasts in dengue patients was significantly lower in patients with primary dengue infection compared to those with secondary dengue. Moreover, within the primary dengue patients, their expansion was significantly lower in patients with mild dengue infection (DI) compared to patients with dengue with warning signs (DW) or severe dengue (SD). These results significantly improve our understanding of human plasmablast responses in dengue. Importance Dengue is a globally spreading with over 100 million clinical cases annually with symptoms ranging from mild self-limiting febrile illness to more severe and sometimes life-threatening dengue hemorrhagic fever or shock, especially among children. India contributes nearly a third of global dengue disease burden. The pathophysiology of dengue is complex and remains poorly understood despite many advances indicating a key role for antibody dependent enhancement of infection. While serum antibodies have been extensively studied, the characteristics of the cellular factories responsible for antibody production, i.e., plasmablasts, are only beginning to emerge. This study provides a comprehensive understanding of the magnitude, phenotype, functional and transcriptional profiles of human plasmablasts from dengue patients in India." @default.
• W3201398410 created "2021-09-27" @default.
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• W3201398410 date "2021-04-11" @default.
• W3201398410 modified "2023-09-30" @default.
• W3201398410 title "Immunophenotyping and transcriptional profiling of human plasmablasts in dengue" @default.
• W3201398410 cites W1521119381 @default.
• W3201398410 cites W1544876647 @default.
• W3201398410 cites W183775175 @default.
• W3201398410 cites W1873321295 @default.
• W3201398410 cites W1884915680 @default.
• W3201398410 cites W1904386998 @default.
• W3201398410 cites W1964731080 @default.
• W3201398410 cites W1973587186 @default.
• W3201398410 cites W1975216289 @default.
• W3201398410 cites W1975852576 @default.
• W3201398410 cites W1976302032 @default.
• W3201398410 cites W1980717479 @default.
• W3201398410 cites W1983305047 @default.
• W3201398410 cites W1988165411 @default.
• W3201398410 cites W1992499848 @default.
• W3201398410 cites W1994032414 @default.
• W3201398410 cites W1997307365 @default.
• W3201398410 cites W2000119111 @default.
• W3201398410 cites W2001710332 @default.
• W3201398410 cites W2002206719 @default.
• W3201398410 cites W2013054229 @default.
• W3201398410 cites W2022228445 @default.
• W3201398410 cites W2025922921 @default.
• W3201398410 cites W2032920239 @default.
• W3201398410 cites W2040288464 @default.
• W3201398410 cites W2052360985 @default.
• W3201398410 cites W2052599602 @default.
• W3201398410 cites W2053595706 @default.
• W3201398410 cites W2054531472 @default.
• W3201398410 cites W2055510343 @default.
• W3201398410 cites W2064681773 @default.
• W3201398410 cites W2064737300 @default.
• W3201398410 cites W2065138170 @default.
• W3201398410 cites W2066108168 @default.
• W3201398410 cites W2073745127 @default.
• W3201398410 cites W2076774296 @default.
• W3201398410 cites W2081356962 @default.
• W3201398410 cites W2090803751 @default.
• W3201398410 cites W2094527424 @default.
• W3201398410 cites W2095109339 @default.
• W3201398410 cites W2099499418 @default.
• W3201398410 cites W2106137449 @default.
• W3201398410 cites W2106566281 @default.
• W3201398410 cites W2111174637 @default.
• W3201398410 cites W2112514322 @default.
• W3201398410 cites W2113180936 @default.
• W3201398410 cites W2123106337 @default.
• W3201398410 cites W2123608788 @default.
• W3201398410 cites W2123708888 @default.
• W3201398410 cites W2126971544 @default.
• W3201398410 cites W2130410032 @default.
• W3201398410 cites W2131222241 @default.
• W3201398410 cites W2132222340 @default.
• W3201398410 cites W2133322087 @default.
• W3201398410 cites W2137441445 @default.
• W3201398410 cites W2139478711 @default.
• W3201398410 cites W2139979516 @default.
• W3201398410 cites W2140864706 @default.
• W3201398410 cites W2141536820 @default.
• W3201398410 cites W2146074826 @default.
• W3201398410 cites W2150098469 @default.
• W3201398410 cites W2152970933 @default.
• W3201398410 cites W2155484006 @default.
• W3201398410 cites W2165848159 @default.
• W3201398410 cites W2165921560 @default.
• W3201398410 cites W2177201093 @default.
• W3201398410 cites W2179438025 @default.
• W3201398410 cites W2256597409 @default.
• W3201398410 cites W2297808287 @default.
• W3201398410 cites W2331992193 @default.
• W3201398410 cites W2413545477 @default.
• W3201398410 cites W2510979876 @default.
• W3201398410 cites W2514633803 @default.

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