FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201407858> ?p ?o ?g. }

• W3201407858 endingPage "607" @default.
• W3201407858 startingPage "607" @default.
• W3201407858 abstract "2582 Bax Inhibitor-1 (BI-1) is an evolutionarily conserved ER protein that was identified as a suppressor of Bax-induced cell death in a yeast-based screen (Xu & Reed, Mol Cell 1: 337, 1998) and that has the ability to suppress cell death in both animal and plant cells. Interestingly, the BI-1 protein has been shown to regulate Ca2+ handling by the ER, as described for several Bcl-2-family proteins which also reside at least in part in ER membranes, where they appear to control levels of releasable Ca2+ in this organelle. Moreover, an effect on cell cycle entry by Bcl-2/Bcl-xL family proteins has been described. These observations with Bcl-2/Bax family proteins therefore prompted us to explore whether bi-1-deficient mice display alterations in liver regeneration. Accordingly, we compared bi-1 (+/+) and bi-1 (−/−) mice subjected to partial hepatectomy (PH) with respect to the kinetics of liver regeneration, and associated events of hepatocyte proliferation, induction of cyclins, phosphorylation of Rb, and other molecular events. We report here that bi-1 regulates hepatocyte proliferation in vivo following PH. We demonstrated that bi-1-deficiency accelerates liver regeneration after PH. Regenerating hepatocytes of bi-1-deficient mice enter cell cycle faster, as documented by more rapid accumulation of BrdU-incorporating cells, associated with earlier increases in Cyclin D1, Cyclin D3, Cdk-2 and Cdk-4 protein levels, more rapid hyperphosphorylation of RB, and faster degradation of p27kip1. Ablation of bi-1 however does not disturb the homeostatic mechanisms that signal for cessation of hepatocyte proliferation once liver size has been restored, as liver weights of bi-1−/− mice did not exceed normal values after completion of regeneration. Altogether therefore this study of the effects of bi-1 deficiency on liver regeneration reveals additional similarities between BI-1 and Bcl-2/Bax-family proteins, showing a role for BI-1 in regulating cell proliferation in vivo, in addition to its previously described actions as a regulator of apoptosis. While much remains to be learned about the molecular mechanisms involved, elucidation of the signaling pathways modulated by BI-1 may provide new insights for improved understanding and possibly treatment of proliferative and degenerative diseases." @default.
• W3201407858 created "2021-09-27" @default.
• W3201407858 creator A5002188124 @default.
• W3201407858 creator A5004174935 @default.
• W3201407858 creator A5013437405 @default.
• W3201407858 creator A5054918775 @default.
• W3201407858 creator A5058524912 @default.
• W3201407858 creator A5059438505 @default.
• W3201407858 creator A5082603032 @default.
• W3201407858 creator A5083228866 @default.
• W3201407858 date "2005-05-01" @default.
• W3201407858 modified "2023-10-17" @default.
• W3201407858 title "Mice lacking bi-1 gene demonstrate accelerated liver regeneration" @default.
• W3201407858 cites W1522731616 @default.
• W3201407858 cites W1522763255 @default.
• W3201407858 cites W1679452661 @default.
• W3201407858 cites W1901253172 @default.
• W3201407858 cites W1923651867 @default.
• W3201407858 cites W1969836383 @default.
• W3201407858 cites W1980166477 @default.
• W3201407858 cites W1998492363 @default.
• W3201407858 cites W2004763695 @default.
• W3201407858 cites W2011863151 @default.
• W3201407858 cites W2021430023 @default.
• W3201407858 cites W2025421728 @default.
• W3201407858 cites W2032880746 @default.
• W3201407858 cites W2034277114 @default.
• W3201407858 cites W2041690669 @default.
• W3201407858 cites W2042165138 @default.
• W3201407858 cites W2043256229 @default.
• W3201407858 cites W2043493252 @default.
• W3201407858 cites W2045631311 @default.
• W3201407858 cites W2047364183 @default.
• W3201407858 cites W2054820743 @default.
• W3201407858 cites W2055209830 @default.
• W3201407858 cites W2061948197 @default.
• W3201407858 cites W2064194904 @default.
• W3201407858 cites W2066099322 @default.
• W3201407858 cites W2066275626 @default.
• W3201407858 cites W2072482644 @default.
• W3201407858 cites W2078533052 @default.
• W3201407858 cites W2080457496 @default.
• W3201407858 cites W2084498285 @default.
• W3201407858 cites W2086090484 @default.
• W3201407858 cites W2086371845 @default.
• W3201407858 cites W2086595059 @default.
• W3201407858 cites W2101179323 @default.
• W3201407858 cites W2103061779 @default.
• W3201407858 cites W2105073777 @default.
• W3201407858 cites W2133258035 @default.
• W3201407858 cites W2133795104 @default.
• W3201407858 cites W2140707292 @default.
• W3201407858 cites W2141000153 @default.
• W3201407858 cites W2146774552 @default.
• W3201407858 cites W2148607448 @default.
• W3201407858 cites W2162522735 @default.
• W3201407858 cites W2167870644 @default.
• W3201407858 cites W2171933068 @default.
• W3201407858 cites W2245791631 @default.
• W3201407858 cites W2247149472 @default.
• W3201407858 cites W227887930 @default.
• W3201407858 cites W2285466600 @default.
• W3201407858 cites W2319159316 @default.
• W3201407858 cites W29091496 @default.
• W3201407858 cites W43675158 @default.
• W3201407858 cites W96728624 @default.
• W3201407858 cites W2466668933 @default.
• W3201407858 hasPublicationYear "2005" @default.
• W3201407858 type Work @default.
• W3201407858 sameAs 3201407858 @default.
• W3201407858 citedByCount "0" @default.
• W3201407858 crossrefType "journal-article" @default.
• W3201407858 hasAuthorship W3201407858A5002188124 @default.
• W3201407858 hasAuthorship W3201407858A5004174935 @default.
• W3201407858 hasAuthorship W3201407858A5013437405 @default.
• W3201407858 hasAuthorship W3201407858A5054918775 @default.
• W3201407858 hasAuthorship W3201407858A5058524912 @default.
• W3201407858 hasAuthorship W3201407858A5059438505 @default.
• W3201407858 hasAuthorship W3201407858A5082603032 @default.
• W3201407858 hasAuthorship W3201407858A5083228866 @default.
• W3201407858 hasConcept C11960822 @default.
• W3201407858 hasConcept C120089663 @default.
• W3201407858 hasConcept C124320809 @default.
• W3201407858 hasConcept C1491633281 @default.
• W3201407858 hasConcept C16438837 @default.
• W3201407858 hasConcept C171056886 @default.
• W3201407858 hasConcept C190283241 @default.
• W3201407858 hasConcept C199835354 @default.
• W3201407858 hasConcept C202751555 @default.
• W3201407858 hasConcept C2776062698 @default.
• W3201407858 hasConcept C2776200302 @default.
• W3201407858 hasConcept C2776795407 @default.
• W3201407858 hasConcept C2778198054 @default.
• W3201407858 hasConcept C29537977 @default.
• W3201407858 hasConcept C31573885 @default.
• W3201407858 hasConcept C55493867 @default.
• W3201407858 hasConcept C62112901 @default.
• W3201407858 hasConcept C86803240 @default.

• next