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- W3201423224 endingPage "1479" @default.
- W3201423224 startingPage "1474" @default.
- W3201423224 abstract "Cancer is a major cause of global mortality underpinned by genomic and epigenomic derangements. Here, we highlight the importance of multimodal data integration in understanding the molecular evolution of malignant cell states across the cancer life cycle. The widespread presence of driver mutations and epigenetic alterations in normal-appearing tissues is prompting a reassessment of how cancer initiation is defined. In later-stage cancers, studying the roles of clonal selection, epigenomic adaptation, and persister cells in metastasis and therapy resistance is an emerging field. Finally, the importance of tumor ecosystems in driving cancer development is being unraveled by single-cell and spatial technologies at unprecedented resolution. Improving cancer risk assessment and accelerating therapeutic discovery for patients will require robust, comprehensive, and integrated temporal, spatial, and multilevel tumor atlases across the cancer life cycle." @default.
- W3201423224 created "2021-09-27" @default.
- W3201423224 creator A5003742732 @default.
- W3201423224 creator A5041095680 @default.
- W3201423224 creator A5073677729 @default.
- W3201423224 date "2021-09-24" @default.
- W3201423224 modified "2023-10-11" @default.
- W3201423224 title "Mapping genomic and epigenomic evolution in cancer ecosystems" @default.
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- W3201423224 doi "https://doi.org/10.1126/science.abh1645" @default.
- W3201423224 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34554797" @default.
- W3201423224 hasPublicationYear "2021" @default.
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