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- W3201436269 endingPage "113" @default.
- W3201436269 startingPage "104" @default.
- W3201436269 abstract "It has been nearly 60 years since Dr John Gurdon achieved the first cloning of Xenopus by somatic cell nuclear transfer (SCNT). Later, in 2006, Takahashi and Yamanaka published their landmark study demonstrating the application of four transcription factors to induce pluripotency. These two amazing discoveries both clearly established that cell identity can be reprogrammed and that mature cells still contain the information required for lineage specification. Considering that different cell types possess identical genomes, what orchestrates reprogramming has attracted wide interest. Epigenetics, including high-level chromatin structure, might provide some answers. Benefitting from the tremendous progress in high-throughput and multi-omics techniques, we here address the roles and interactions of genome architecture, chromatin modifications, and transcription regulation during somatic cell reprogramming that were previously beyond reach. In addition, we provide perspectives on recent technical advances that might help to overcome certain barriers in the field." @default.
- W3201436269 created "2021-09-27" @default.
- W3201436269 creator A5018158429 @default.
- W3201436269 creator A5037741749 @default.
- W3201436269 creator A5038635573 @default.
- W3201436269 creator A5058603003 @default.
- W3201436269 date "2021-10-01" @default.
- W3201436269 modified "2023-10-13" @default.
- W3201436269 title "Chromatin architecture reorganization during somatic cell reprogramming" @default.
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