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- W3201438891 abstract "The cervix acts as a dynamic barrier between the uterus and vagina, retaining the fetus during pregnancy and allowing birth at term. Critical to this function, the physical properties of the cervix change, or remodel, but dysfunctional remodeling can lead to preterm birth (PTB). Although cervical remodeling has been studied, the complex 3D cervical microstructure has not been well-characterized. In this complex, dynamic, and heterogeneous tissue microenvironment, the microstructural changes are likely also heterogeneous. Using quantitative, 3D, second-harmonic generation microscopy, we demonstrate that cervical remodeling is not uniform across the cervix; during pregnancy, the collagen fibers orient progressively more perpendicular to the cervical canals in the inner cervical zone, but do not reorient in other regions. Furthermore, regions that are microstructurally distinct early in pregnancy become more similar as pregnancy progresses. We use a finite element simulation to show that heterogeneous regional changes influence cervical funneling, an important marker of increased risk for PTB; the proximal portion of the cervix shows ~6.5x larger radial displacement when fibers in the inner cervical zone are parallel to the cervical canals compared to when fibers are perpendicular to the canals. Our results provide new insights into the microstructural and tissue-level cervical changes that have been correlated with PTB and provide a new explanation for a possible origin of cervical funneling.Funding Information: Kimani C. Toussaint, Ph.D., holds a 2017 Preterm Birth Research Grant from the Burroughs Wellcome Fund (#1017300). Research reported in this publication was partly supported by the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health under Award Number T32EB019944. Declaration of Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.Ethics Approval Statement: All procedures were approved by the Institutional Animal Care and Use Committee at the University of Illinois at Urbana-Champaign." @default.
- W3201438891 created "2021-09-27" @default.
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- W3201438891 date "2021-01-01" @default.
- W3201438891 modified "2023-09-23" @default.
- W3201438891 title "Heterogeneous Microstructural Changes of the Cervix Influence Cervical Funneling" @default.
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- W3201438891 doi "https://doi.org/10.2139/ssrn.3919739" @default.
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