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- W3201438982 abstract "The design of catalysts with greater control over catalytic activity and stability is a major challenge with substantial impact on fundamental chemistry and industrial applications. Due to their unparalleled diversity, selectivity, and efficiency, enzymes are promising models for next-generation catalysts, and considerable efforts have been devoted to incorporating the principles of their mechanisms of action into artificial systems. We report a heretofore undocumented catalyst design that introduces fullerenes to the field of biocatalysis, which we refer to as fullerene nanocatalysts, and that emulates enzymatic active sites through multifunctional self-assembled nanostructures. As a proof-of-concept, we mimicked the reactivity of hydrolases using fullerene nanocatalysts functionalized with the basic components of the parent enzyme with remarkable activity. Owing to the versatile amino acid-based functionalization repertoire of fullerene nanocatalysts, these next-generation carbon/biomolecule hybrids have potential to mimic the activity of other families of enzymes and, therefore, offer new perspectives for the design of biocompatible, high-efficiency artificial nanocatalysts." @default.
- W3201438982 created "2021-09-27" @default.
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- W3201438982 date "2021-09-14" @default.
- W3201438982 modified "2023-10-16" @default.
- W3201438982 title "Fullerene-Based Mimics of Biocatalysts Show Remarkable Activity and Modularity" @default.
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- W3201438982 doi "https://doi.org/10.1021/acsami.1c11516" @default.
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- W3201438982 hasPublicationYear "2021" @default.
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