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• W3201453693 abstract "Macrophages exhibit a spectrum of activation states ranging from classical to alternative activation1. Alternatively, activated macrophages are involved in diverse pathophysiological processes such as confining tissue parasites2, improving insulin sensitivity3 or promoting an immune-tolerant microenvironment that facilitates tumour growth and metastasis4. Recently, the metabolic regulation of macrophage function has come into focus as both the classical and alternative activation programmes require specific regulated metabolic reprogramming5. While most of the studies regarding immunometabolism have focussed on the catabolic pathways activated to provide energy, little is known about the anabolic pathways mediating macrophage alternative activation. In this study, we show that the anabolic transcription factor sterol regulatory element binding protein 1 (SREBP1) is activated in response to the canonical T helper 2 cell cytokine interleukin-4 to trigger the de novo lipogenesis (DNL) programme, as a necessary step for macrophage alternative activation. Mechanistically, DNL consumes NADPH, partitioning it away from cellular antioxidant defences and raising reactive oxygen species levels. Reactive oxygen species serves as a second messenger, signalling sufficient DNL, and promoting macrophage alternative activation. The pathophysiological relevance of this mechanism is validated by showing that SREBP1/DNL is essential for macrophage alternative activation in vivo in a helminth infection model. Bidault et al. find that interleukin-4 activates SREBP1 to promote de novo lipogenesis that consumes NADPH to drive alternative activation of macrophages through the accumulation of reactive oxygen species." @default.
• W3201453693 created "2021-09-27" @default.
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• W3201453693 date "2021-09-16" @default.
• W3201453693 modified "2023-10-18" @default.
• W3201453693 title "SREBP1-induced fatty acid synthesis depletes macrophages antioxidant defences to promote their alternative activation" @default.
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• W3201453693 cites W1990819855 @default.
• W3201453693 cites W1995299599 @default.
• W3201453693 cites W1997732315 @default.
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• W3201453693 cites W2029188728 @default.
• W3201453693 cites W2031022790 @default.
• W3201453693 cites W2034126502 @default.
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• W3201453693 cites W2120579640 @default.
• W3201453693 cites W2122598723 @default.
• W3201453693 cites W2123105952 @default.
• W3201453693 cites W2123318646 @default.
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• W3201453693 cites W2167778120 @default.
• W3201453693 cites W2168632939 @default.
• W3201453693 cites W2180194616 @default.
• W3201453693 cites W2191790139 @default.
• W3201453693 cites W2206617731 @default.
• W3201453693 cites W2273755854 @default.
• W3201453693 cites W2522492952 @default.
• W3201453693 cites W2548058740 @default.
• W3201453693 cites W2566581841 @default.
• W3201453693 cites W2620241325 @default.
• W3201453693 cites W2727093975 @default.
• W3201453693 cites W2752390584 @default.
• W3201453693 cites W2784315882 @default.
• W3201453693 cites W2788772427 @default.
• W3201453693 cites W2810749981 @default.
• W3201453693 cites W2891826366 @default.
• W3201453693 cites W2895487889 @default.
• W3201453693 cites W2897547577 @default.
• W3201453693 cites W2904366212 @default.
• W3201453693 cites W2904790460 @default.
• W3201453693 cites W2905558687 @default.
• W3201453693 cites W2921800534 @default.
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• W3201453693 doi "https://doi.org/10.1038/s42255-021-00440-5" @default.
• W3201453693 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7611716" @default.
• W3201453693 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34531575" @default.
• W3201453693 hasPublicationYear "2021" @default.
• W3201453693 type Work @default.

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