FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201457789> ?p ?o ?g. }

• W3201457789 endingPage "713" @default.
• W3201457789 startingPage "703" @default.
• W3201457789 abstract "Iron dyshomeostasis is associated with hepatocellular carcinoma (HCC) development. However, the role of iron in HCC metastasis is unknown. This study aimed to elucidate the underlying mechanisms of iron’s enhancement activity on HCC metastasis. In addition to the HCC cell lines and clinical samples in vitro, iron-deficient (ID) mouse models were generated using iron-free diet and transferrin receptor protein knockout, followed by administration of HCC tumors through either orthotopic or ectopic route. Clinical metastatic HCC samples showed significant ID status, accompanied by overexpression of sphingosine-1-phosphate transporter spinster homolog 2 (SPNS2). Mechanistically, ID increased SPNS2 expression, leading to HCC metastasis in both cell cultures and mouse models. ID not only altered the anti-tumor immunity, which was indicated by phenotypes of lymphatic subsets in the liver and lung of tumor-bearing mice, but also promoted HCC metastasis in a cancer cell autonomous manner through the SPNS2. Since germline knockout of globe SPNS2 showed significantly reduced HCC metastasis, we further developed hepatic-targeting recombinant adeno-associated virus vectors to knockdown SPNS2 expression and to inhibit iron-regulated HCC metastasis. Our observation indicates the role of iron in HCC pulmonary metastasis and suggests SPNS2 as a potential therapeutic target for the prevention of HCC pulmonary metastasis. Iron dyshomeostasis is associated with hepatocellular carcinoma (HCC) development. However, the role of iron in HCC metastasis is unknown. This study aimed to elucidate the underlying mechanisms of iron’s enhancement activity on HCC metastasis. In addition to the HCC cell lines and clinical samples in vitro, iron-deficient (ID) mouse models were generated using iron-free diet and transferrin receptor protein knockout, followed by administration of HCC tumors through either orthotopic or ectopic route. Clinical metastatic HCC samples showed significant ID status, accompanied by overexpression of sphingosine-1-phosphate transporter spinster homolog 2 (SPNS2). Mechanistically, ID increased SPNS2 expression, leading to HCC metastasis in both cell cultures and mouse models. ID not only altered the anti-tumor immunity, which was indicated by phenotypes of lymphatic subsets in the liver and lung of tumor-bearing mice, but also promoted HCC metastasis in a cancer cell autonomous manner through the SPNS2. Since germline knockout of globe SPNS2 showed significantly reduced HCC metastasis, we further developed hepatic-targeting recombinant adeno-associated virus vectors to knockdown SPNS2 expression and to inhibit iron-regulated HCC metastasis. Our observation indicates the role of iron in HCC pulmonary metastasis and suggests SPNS2 as a potential therapeutic target for the prevention of HCC pulmonary metastasis." @default.
• W3201457789 created "2021-09-27" @default.
• W3201457789 creator A5000948683 @default.
• W3201457789 creator A5029634246 @default.
• W3201457789 creator A5036159697 @default.
• W3201457789 creator A5043415898 @default.
• W3201457789 creator A5049897805 @default.
• W3201457789 creator A5061703157 @default.
• W3201457789 creator A5062265807 @default.
• W3201457789 creator A5063638780 @default.
• W3201457789 creator A5064000923 @default.
• W3201457789 creator A5065178862 @default.
• W3201457789 creator A5068400760 @default.
• W3201457789 creator A5075261929 @default.
• W3201457789 creator A5081093203 @default.
• W3201457789 date "2022-02-01" @default.
• W3201457789 modified "2023-10-16" @default.
• W3201457789 title "Sphingosine-1-phosphate transporter spinster homolog 2 is essential for iron-regulated metastasis of hepatocellular carcinoma" @default.
• W3201457789 cites W1513392008 @default.
• W3201457789 cites W1642891300 @default.
• W3201457789 cites W1971837077 @default.
• W3201457789 cites W1985987855 @default.
• W3201457789 cites W2022687771 @default.
• W3201457789 cites W2029426792 @default.
• W3201457789 cites W2052817233 @default.
• W3201457789 cites W2055894717 @default.
• W3201457789 cites W2056477869 @default.
• W3201457789 cites W2062107099 @default.
• W3201457789 cites W2070677984 @default.
• W3201457789 cites W2114202720 @default.
• W3201457789 cites W2140413818 @default.
• W3201457789 cites W2148889412 @default.
• W3201457789 cites W2152855697 @default.
• W3201457789 cites W2163038863 @default.
• W3201457789 cites W2165680505 @default.
• W3201457789 cites W2235104412 @default.
• W3201457789 cites W2323751645 @default.
• W3201457789 cites W2401533913 @default.
• W3201457789 cites W2530391744 @default.
• W3201457789 cites W2570611720 @default.
• W3201457789 cites W2571554990 @default.
• W3201457789 cites W2602454999 @default.
• W3201457789 cites W2604986078 @default.
• W3201457789 cites W2725217833 @default.
• W3201457789 cites W2754409957 @default.
• W3201457789 cites W2768270891 @default.
• W3201457789 cites W2772282916 @default.
• W3201457789 cites W2803788332 @default.
• W3201457789 cites W2887831066 @default.
• W3201457789 cites W2888091897 @default.
• W3201457789 cites W2889646458 @default.
• W3201457789 cites W2897980119 @default.
• W3201457789 cites W2900734684 @default.
• W3201457789 cites W2902378153 @default.
• W3201457789 cites W2909455494 @default.
• W3201457789 cites W2911646196 @default.
• W3201457789 cites W3012192257 @default.
• W3201457789 cites W3022193398 @default.
• W3201457789 cites W3153499476 @default.
• W3201457789 cites W3173438664 @default.
• W3201457789 cites W4233526312 @default.
• W3201457789 doi "https://doi.org/10.1016/j.ymthe.2021.09.012" @default.
• W3201457789 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34547466" @default.
• W3201457789 hasPublicationYear "2022" @default.
• W3201457789 type Work @default.
• W3201457789 sameAs 3201457789 @default.
• W3201457789 citedByCount "14" @default.
• W3201457789 countsByYear W32014577892022 @default.
• W3201457789 countsByYear W32014577892023 @default.
• W3201457789 crossrefType "journal-article" @default.
• W3201457789 hasAuthorship W3201457789A5000948683 @default.
• W3201457789 hasAuthorship W3201457789A5029634246 @default.
• W3201457789 hasAuthorship W3201457789A5036159697 @default.
• W3201457789 hasAuthorship W3201457789A5043415898 @default.
• W3201457789 hasAuthorship W3201457789A5049897805 @default.
• W3201457789 hasAuthorship W3201457789A5061703157 @default.
• W3201457789 hasAuthorship W3201457789A5062265807 @default.
• W3201457789 hasAuthorship W3201457789A5063638780 @default.
• W3201457789 hasAuthorship W3201457789A5064000923 @default.
• W3201457789 hasAuthorship W3201457789A5065178862 @default.
• W3201457789 hasAuthorship W3201457789A5068400760 @default.
• W3201457789 hasAuthorship W3201457789A5075261929 @default.
• W3201457789 hasAuthorship W3201457789A5081093203 @default.
• W3201457789 hasBestOaLocation W32014577891 @default.
• W3201457789 hasConcept C104317684 @default.
• W3201457789 hasConcept C121608353 @default.
• W3201457789 hasConcept C126322002 @default.
• W3201457789 hasConcept C142724271 @default.
• W3201457789 hasConcept C149011108 @default.
• W3201457789 hasConcept C2776531687 @default.
• W3201457789 hasConcept C2778019345 @default.
• W3201457789 hasConcept C2779013556 @default.
• W3201457789 hasConcept C502942594 @default.
• W3201457789 hasConcept C55493867 @default.
• W3201457789 hasConcept C71924100 @default.
• W3201457789 hasConcept C86803240 @default.
• W3201457789 hasConceptScore W3201457789C104317684 @default.
• W3201457789 hasConceptScore W3201457789C121608353 @default.

• next