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• W3201474899 abstract "Spinal cord injury (SCI) is a devastating condition that results in severe motor, sensory, and autonomic dysfunction. The L-/T-type calcium channel blocker nimodipine (NMD) exerts a protective effect on neuronal injury; however, the protective effects of long-term administration of NMD in subjects with SCI remain unknown. Thus, the aim of this study was to evaluate the role of long-term treatment with NMD on a clinically relevant SCI model. Female rats with SCI induced by 25 mm contusion were subcutaneously injected with vehicle or 10 mg/kg NMD daily for six consecutive weeks. We monitored the motor score, hind limb grip strength, pain-related behaviors, and bladder function in this study to assess the efficacy of NMD in rats with SCI. Rats treated with NMD showed improvements in locomotion, pain-related behaviors, and spasticity-like symptoms, but not in open-field spontaneous activity, hind limb grip strength or bladder function. SCI lesion areas and perilesional neuronal numbers, gliosis and calcitonin gene-related peptide (CGRP + ) fiber sprouting in the lumbar spinal cord and the expression of K + –Cl − cotransporter 2 (KCC2) on lumbar motor neurons were also observed to further explore the possible protective mechanisms of NMD. NMD-treated rats showed greater tissue preservation with reduced lesion areas and increased perilesional neuronal sparing. NMD-treated rats also showed improvements in gliosis, CGRP + fiber sprouting in the lumbar spinal cord, and KCC2 expression in lumbar motor neurons. Together, these results indicate that long-term treatment with NMD improves functional recovery after SCI, which may provide a potential therapeutic strategy for the treatment of SCI." @default.
• W3201474899 created "2021-09-27" @default.
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• W3201474899 date "2021-09-13" @default.
• W3201474899 modified "2023-09-26" @default.
• W3201474899 title "Nimodipine Promotes Functional Recovery After Spinal Cord Injury in Rats" @default.
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• W3201474899 doi "https://doi.org/10.3389/fphar.2021.733420" @default.
• W3201474899 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8477750" @default.
• W3201474899 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34594224" @default.
• W3201474899 hasPublicationYear "2021" @default.
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