Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201478141> ?p ?o ?g. }
- W3201478141 abstract "Abstract Coordinated chromatin interactions between enhancers and promoters are critical for gene regulation. The architectural protein CTCF mediates chromatin looping and is enriched at the boundaries of topologically associating domains (TADs), which are sub-megabase chromatin structures. In vitro CTCF depletion leads to a loss of TADs but has only limited effects over gene expression, challenging the concept that CTCF-mediated chromatin structures are a fundamental requirement for gene regulation. However, how CTCF and a perturbed chromatin structure impacts gene expression during development remains poorly understood. Here we link the loss of CTCF and gene regulation during patterning and organogenesis in a ctcf knockout zebrafish model. CTCF absence leads to loss of chromatin structure and affects the expression of thousands of genes, including many developmental regulators. Our results demonstrate the essential role of CTCF in providing the structural context for enhancer-promoter interactions, thus regulating developmental genes." @default.
- W3201478141 created "2021-09-27" @default.
- W3201478141 creator A5003733187 @default.
- W3201478141 creator A5028348405 @default.
- W3201478141 creator A5033461209 @default.
- W3201478141 creator A5040145590 @default.
- W3201478141 creator A5041402608 @default.
- W3201478141 creator A5057382818 @default.
- W3201478141 creator A5057573640 @default.
- W3201478141 creator A5067249637 @default.
- W3201478141 creator A5088569716 @default.
- W3201478141 date "2021-09-13" @default.
- W3201478141 modified "2023-10-18" @default.
- W3201478141 title "CTCF knockout in zebrafish induces alterations in regulatory landscapes and developmental gene expression" @default.
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