FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201487097> ?p ?o ?g. }

• W3201487097 endingPage "1232" @default.
• W3201487097 startingPage "1223" @default.
• W3201487097 abstract "Female breast cancer has become the most commonly diagnosed cancer worldwide. As a tumor suppressor, estrogen receptor β (ERβ) can be potentially targeted for breast cancer therapy.TAD1822-7 was evaluated for ERβ-mediated autophagy and cell death using cell proliferation assay, Annexin V/PI staining, immunofluorescence, western blotting, ERβ siRNA, ERβ plasmid transfection and hypoxia cell models. TAD1822-7 upregulated ERβ causing cell death and induced mitochondrial dysfunction and autophagy companied with mitochondrial located ERβ. Enhanced levels of microtubule associated protein1 light chain 3 (LC3)-II and p62/SQSTM1 (p62) indicated that TAD1822-7 blocked the late-stage autolysosome formation, leading to cell death. Mechanistically, TAD1822-7-induced cell death was mediated by phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) signaling pathways. Moreover, TAD1822-7 modulated hypoxia inducible factor (HIF) functions and autophagy via the inhibition of HIF-1β in the context of hypoxia-induced autophagy. ERβ overexpression and ERβ agonist showed similar effects, whereas ERβ siRNA abrogated TAD1822-7-induced cell death, the inhibition of PI3K/AKT pathway and autophagy. The involvement of PI3K/AKT pathway and autophagy was also demonstrated in TAD1822-7-treated hypoxic breast cancer cells.These findings provide new insight into the mechanism underlying the inhibitory effects of TAD1822-7 via ERβ-mediated pathways in breast cancer cells." @default.
• W3201487097 created "2021-09-27" @default.
• W3201487097 creator A5023346134 @default.
• W3201487097 creator A5037481250 @default.
• W3201487097 creator A5042325449 @default.
• W3201487097 creator A5046822662 @default.
• W3201487097 creator A5078988597 @default.
• W3201487097 creator A5083069101 @default.
• W3201487097 date "2021-11-18" @default.
• W3201487097 modified "2023-10-15" @default.
• W3201487097 title "Induction of estrogen receptor β-mediated autophagy sensitizes breast cancer cells to TAD1822-7, a novel biphenyl urea taspine derivative" @default.
• W3201487097 cites W1917948530 @default.
• W3201487097 cites W1991880013 @default.
• W3201487097 cites W2003639182 @default.
• W3201487097 cites W2011611385 @default.
• W3201487097 cites W2018722597 @default.
• W3201487097 cites W2036501990 @default.
• W3201487097 cites W2045122835 @default.
• W3201487097 cites W2050981141 @default.
• W3201487097 cites W2118089000 @default.
• W3201487097 cites W2136912731 @default.
• W3201487097 cites W2536431286 @default.
• W3201487097 cites W2740618823 @default.
• W3201487097 cites W2743136946 @default.
• W3201487097 cites W2767490296 @default.
• W3201487097 cites W2967165574 @default.
• W3201487097 cites W2973354209 @default.
• W3201487097 cites W2990689967 @default.
• W3201487097 cites W2992433783 @default.
• W3201487097 cites W3033852492 @default.
• W3201487097 cites W3084097361 @default.
• W3201487097 cites W3094559596 @default.
• W3201487097 cites W3128646645 @default.
• W3201487097 cites W4253363877 @default.
• W3201487097 cites W4254801662 @default.
• W3201487097 doi "https://doi.org/10.1007/s11033-021-06950-5" @default.
• W3201487097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34792729" @default.
• W3201487097 hasPublicationYear "2021" @default.
• W3201487097 type Work @default.
• W3201487097 sameAs 3201487097 @default.
• W3201487097 citedByCount "2" @default.
• W3201487097 countsByYear W32014870972022 @default.
• W3201487097 countsByYear W32014870972023 @default.
• W3201487097 crossrefType "journal-article" @default.
• W3201487097 hasAuthorship W3201487097A5023346134 @default.
• W3201487097 hasAuthorship W3201487097A5037481250 @default.
• W3201487097 hasAuthorship W3201487097A5042325449 @default.
• W3201487097 hasAuthorship W3201487097A5046822662 @default.
• W3201487097 hasAuthorship W3201487097A5078988597 @default.
• W3201487097 hasAuthorship W3201487097A5083069101 @default.
• W3201487097 hasBestOaLocation W32014870972 @default.
• W3201487097 hasConcept C121608353 @default.
• W3201487097 hasConcept C185592680 @default.
• W3201487097 hasConcept C190283241 @default.
• W3201487097 hasConcept C203522944 @default.
• W3201487097 hasConcept C31573885 @default.
• W3201487097 hasConcept C502942594 @default.
• W3201487097 hasConcept C530470458 @default.
• W3201487097 hasConcept C54355233 @default.
• W3201487097 hasConcept C55493867 @default.
• W3201487097 hasConcept C62478195 @default.
• W3201487097 hasConcept C75217442 @default.
• W3201487097 hasConcept C84606932 @default.
• W3201487097 hasConcept C86554907 @default.
• W3201487097 hasConcept C86803240 @default.
• W3201487097 hasConcept C95444343 @default.
• W3201487097 hasConcept C96232424 @default.
• W3201487097 hasConceptScore W3201487097C121608353 @default.
• W3201487097 hasConceptScore W3201487097C185592680 @default.
• W3201487097 hasConceptScore W3201487097C190283241 @default.
• W3201487097 hasConceptScore W3201487097C203522944 @default.
• W3201487097 hasConceptScore W3201487097C31573885 @default.
• W3201487097 hasConceptScore W3201487097C502942594 @default.
• W3201487097 hasConceptScore W3201487097C530470458 @default.
• W3201487097 hasConceptScore W3201487097C54355233 @default.
• W3201487097 hasConceptScore W3201487097C55493867 @default.
• W3201487097 hasConceptScore W3201487097C62478195 @default.
• W3201487097 hasConceptScore W3201487097C75217442 @default.
• W3201487097 hasConceptScore W3201487097C84606932 @default.
• W3201487097 hasConceptScore W3201487097C86554907 @default.
• W3201487097 hasConceptScore W3201487097C86803240 @default.
• W3201487097 hasConceptScore W3201487097C95444343 @default.
• W3201487097 hasConceptScore W3201487097C96232424 @default.
• W3201487097 hasFunder F4320321001 @default.
• W3201487097 hasIssue "2" @default.
• W3201487097 hasLocation W32014870971 @default.
• W3201487097 hasLocation W32014870972 @default.
• W3201487097 hasLocation W32014870973 @default.
• W3201487097 hasOpenAccess W3201487097 @default.
• W3201487097 hasPrimaryLocation W32014870971 @default.
• W3201487097 hasRelatedWork W1585268103 @default.
• W3201487097 hasRelatedWork W2084880710 @default.
• W3201487097 hasRelatedWork W2127153258 @default.
• W3201487097 hasRelatedWork W2147371753 @default.
• W3201487097 hasRelatedWork W2355246966 @default.
• W3201487097 hasRelatedWork W3002644491 @default.
• W3201487097 hasRelatedWork W3089957099 @default.
• W3201487097 hasRelatedWork W3140193828 @default.

• next