Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201491500> ?p ?o ?g. }
- W3201491500 endingPage "1249" @default.
- W3201491500 startingPage "1249" @default.
- W3201491500 abstract "In gastric cancer (GC), biomarkers that define prognosis and predict treatment response remain scarce. We hypothesized that the extent of CD44v6 membranous tumor expression could predict prognosis and therapy response in GC patients. Two GC surgical cohorts, from Portugal and South Korea (n = 964), were characterized for the extension of CD44v6 membranous immuno-expression, clinicopathological features, patient survival, and therapy response. The value of CD44v6 expression in predicting response to treatment and its impact on prognosis was determined. High CD44v6 expression was associated with invasive features (perineural invasion and depth of invasion) in both cohorts and with worse survival in the Portuguese GC cohort (HR 1.461; 95% confidence interval 1.002–2.131). Patients with high CD44v6 tumor expression benefited from conventional chemotherapy in addition to surgery (p < 0.05), particularly those with heterogeneous CD44v6-positive and -negative populations (CD44v6_3+) (p < 0.007 and p < 0.009). Our study is the first to identify CD44v6 high membranous expression as a potential predictive marker of response to conventional treatment, but it does not clarify CD44v6 prognostic value in GC. Importantly, our data support selection of GC patients with high CD44v6-expressing tumors for conventional chemotherapy in addition to surgery. These findings will allow better stratification of GC patients for treatment, potentially improving their overall survival." @default.
- W3201491500 created "2021-09-27" @default.
- W3201491500 creator A5008404992 @default.
- W3201491500 creator A5009075091 @default.
- W3201491500 creator A5013845955 @default.
- W3201491500 creator A5016034491 @default.
- W3201491500 creator A5017138110 @default.
- W3201491500 creator A5024144266 @default.
- W3201491500 creator A5024362169 @default.
- W3201491500 creator A5026242093 @default.
- W3201491500 creator A5029635423 @default.
- W3201491500 creator A5032972301 @default.
- W3201491500 creator A5035504752 @default.
- W3201491500 creator A5053228557 @default.
- W3201491500 creator A5062132673 @default.
- W3201491500 creator A5064174334 @default.
- W3201491500 creator A5064854472 @default.
- W3201491500 creator A5066708574 @default.
- W3201491500 creator A5075483404 @default.
- W3201491500 creator A5080167570 @default.
- W3201491500 creator A5088058402 @default.
- W3201491500 creator A5089477553 @default.
- W3201491500 date "2021-09-18" @default.
- W3201491500 modified "2023-10-09" @default.
- W3201491500 title "CD44v6 High Membranous Expression Is a Predictive Marker of Therapy Response in Gastric Cancer Patients" @default.
- W3201491500 cites W1576469977 @default.
- W3201491500 cites W1806659761 @default.
- W3201491500 cites W1973695309 @default.
- W3201491500 cites W1996657856 @default.
- W3201491500 cites W2055186246 @default.
- W3201491500 cites W2065864513 @default.
- W3201491500 cites W2087139600 @default.
- W3201491500 cites W2095782040 @default.
- W3201491500 cites W2100439220 @default.
- W3201491500 cites W2106327747 @default.
- W3201491500 cites W2148438774 @default.
- W3201491500 cites W2155311724 @default.
- W3201491500 cites W2224158681 @default.
- W3201491500 cites W2553294873 @default.
- W3201491500 cites W2561044930 @default.
- W3201491500 cites W2591862276 @default.
- W3201491500 cites W2609452749 @default.
- W3201491500 cites W2895901841 @default.
- W3201491500 cites W2899828045 @default.
- W3201491500 cites W2986860101 @default.
- W3201491500 cites W3013504508 @default.
- W3201491500 cites W3015019021 @default.
- W3201491500 cites W3081253415 @default.
- W3201491500 cites W3128646645 @default.
- W3201491500 doi "https://doi.org/10.3390/biomedicines9091249" @default.
- W3201491500 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8465138" @default.
- W3201491500 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34572441" @default.
- W3201491500 hasPublicationYear "2021" @default.
- W3201491500 type Work @default.
- W3201491500 sameAs 3201491500 @default.
- W3201491500 citedByCount "2" @default.
- W3201491500 countsByYear W32014915002022 @default.
- W3201491500 crossrefType "journal-article" @default.
- W3201491500 hasAuthorship W3201491500A5008404992 @default.
- W3201491500 hasAuthorship W3201491500A5009075091 @default.
- W3201491500 hasAuthorship W3201491500A5013845955 @default.
- W3201491500 hasAuthorship W3201491500A5016034491 @default.
- W3201491500 hasAuthorship W3201491500A5017138110 @default.
- W3201491500 hasAuthorship W3201491500A5024144266 @default.
- W3201491500 hasAuthorship W3201491500A5024362169 @default.
- W3201491500 hasAuthorship W3201491500A5026242093 @default.
- W3201491500 hasAuthorship W3201491500A5029635423 @default.
- W3201491500 hasAuthorship W3201491500A5032972301 @default.
- W3201491500 hasAuthorship W3201491500A5035504752 @default.
- W3201491500 hasAuthorship W3201491500A5053228557 @default.
- W3201491500 hasAuthorship W3201491500A5062132673 @default.
- W3201491500 hasAuthorship W3201491500A5064174334 @default.
- W3201491500 hasAuthorship W3201491500A5064854472 @default.
- W3201491500 hasAuthorship W3201491500A5066708574 @default.
- W3201491500 hasAuthorship W3201491500A5075483404 @default.
- W3201491500 hasAuthorship W3201491500A5080167570 @default.
- W3201491500 hasAuthorship W3201491500A5088058402 @default.
- W3201491500 hasAuthorship W3201491500A5089477553 @default.
- W3201491500 hasBestOaLocation W32014915001 @default.
- W3201491500 hasConcept C121608353 @default.
- W3201491500 hasConcept C126322002 @default.
- W3201491500 hasConcept C143998085 @default.
- W3201491500 hasConcept C2776694085 @default.
- W3201491500 hasConcept C2777154038 @default.
- W3201491500 hasConcept C44249647 @default.
- W3201491500 hasConcept C71924100 @default.
- W3201491500 hasConcept C72563966 @default.
- W3201491500 hasConcept C90924648 @default.
- W3201491500 hasConceptScore W3201491500C121608353 @default.
- W3201491500 hasConceptScore W3201491500C126322002 @default.
- W3201491500 hasConceptScore W3201491500C143998085 @default.
- W3201491500 hasConceptScore W3201491500C2776694085 @default.
- W3201491500 hasConceptScore W3201491500C2777154038 @default.
- W3201491500 hasConceptScore W3201491500C44249647 @default.
- W3201491500 hasConceptScore W3201491500C71924100 @default.
- W3201491500 hasConceptScore W3201491500C72563966 @default.
- W3201491500 hasConceptScore W3201491500C90924648 @default.
- W3201491500 hasIssue "9" @default.