Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201494890> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W3201494890 abstract "Nivolumab is used for the treatment of malignant pleural mesothelioma (MPM). However, immune-related adverse events (irAEs) occur in patients treated with nivolumab. Several studies have reported the correlation between irAEs and therapeutic effects of immune checkpoint inhibitor, but none have reported the correlation in MPM. Here we report a retrospective study which shows the correlation between irAEs and therapeutic effects of nivolumab in patients with MPM.This study included patients treated with nivolumab at Tokushima University Hospital from February 2009 to September 2021. We retrospectively reviewed the medical records to evaluate the several clinical factors, such as the presence or absence of irAEs, their severities, progression-free survival (PFS), overall survival (OS) or objective response to the treatment.Eleven patients received treatment with nivolumab. Objective response rate was 18.2% and the disease control rate was 90.9%. Median PFS was 6.8 months (95% confidence interval, 1.3 to 11.9 months) and median OS was 15.2 months (95% confidence interval, 8.9 to 21.5 months). IrAEs occurred in eight patients (72.7%), and grade ≥ 2 irAEs occurred in six patients (54.5%). PFS and OS were significantly longer in the grade ≥ 2 irAEs group than in grade < 2 irAEs group (median PFS 13.6 vs. 3.8 months, p = 0.0093; median OS not reached vs. 8.6 months, p = 0.0108).This is the first study to report the correlation between irAEs and therapeutic effects in patients with MPM. Because the presence of irAEs may be associated with a favorable clinical outcome, early detection and appropriate management of irAEs will increase the therapeutic benefits to patients." @default.
- W3201494890 created "2021-09-27" @default.
- W3201494890 creator A5004508818 @default.
- W3201494890 creator A5016366834 @default.
- W3201494890 creator A5018111348 @default.
- W3201494890 creator A5020327537 @default.
- W3201494890 creator A5025137523 @default.
- W3201494890 creator A5029110597 @default.
- W3201494890 creator A5071216293 @default.
- W3201494890 creator A5074533118 @default.
- W3201494890 date "2021-11-15" @default.
- W3201494890 modified "2023-10-09" @default.
- W3201494890 title "Correlation between immune-related adverse events and therapeutic effects of nivolumab in patients with malignant pleural mesothelioma" @default.
- W3201494890 cites W1948574410 @default.
- W3201494890 cites W1982488143 @default.
- W3201494890 cites W2010761400 @default.
- W3201494890 cites W2072467542 @default.
- W3201494890 cites W2100576484 @default.
- W3201494890 cites W2102627969 @default.
- W3201494890 cites W2132916434 @default.
- W3201494890 cites W2179179825 @default.
- W3201494890 cites W2473218705 @default.
- W3201494890 cites W2513176323 @default.
- W3201494890 cites W2592847908 @default.
- W3201494890 cites W2759963646 @default.
- W3201494890 cites W2760942750 @default.
- W3201494890 cites W2808133785 @default.
- W3201494890 cites W2948619068 @default.
- W3201494890 cites W2961780602 @default.
- W3201494890 cites W2983284890 @default.
- W3201494890 cites W3016806376 @default.
- W3201494890 cites W3043347519 @default.
- W3201494890 cites W3091399767 @default.
- W3201494890 cites W3118646141 @default.
- W3201494890 doi "https://doi.org/10.1186/s12890-021-01746-6" @default.
- W3201494890 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8591924" @default.
- W3201494890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34781910" @default.
- W3201494890 hasPublicationYear "2021" @default.
- W3201494890 type Work @default.
- W3201494890 sameAs 3201494890 @default.
- W3201494890 citedByCount "1" @default.
- W3201494890 countsByYear W32014948902022 @default.
- W3201494890 crossrefType "journal-article" @default.
- W3201494890 hasAuthorship W3201494890A5004508818 @default.
- W3201494890 hasAuthorship W3201494890A5016366834 @default.
- W3201494890 hasAuthorship W3201494890A5018111348 @default.
- W3201494890 hasAuthorship W3201494890A5020327537 @default.
- W3201494890 hasAuthorship W3201494890A5025137523 @default.
- W3201494890 hasAuthorship W3201494890A5029110597 @default.
- W3201494890 hasAuthorship W3201494890A5071216293 @default.
- W3201494890 hasAuthorship W3201494890A5074533118 @default.
- W3201494890 hasBestOaLocation W32014948901 @default.
- W3201494890 hasConcept C121608353 @default.
- W3201494890 hasConcept C126322002 @default.
- W3201494890 hasConcept C142724271 @default.
- W3201494890 hasConcept C143998085 @default.
- W3201494890 hasConcept C167135981 @default.
- W3201494890 hasConcept C197934379 @default.
- W3201494890 hasConcept C2777407522 @default.
- W3201494890 hasConcept C2777701055 @default.
- W3201494890 hasConcept C2780030458 @default.
- W3201494890 hasConcept C44249647 @default.
- W3201494890 hasConcept C71924100 @default.
- W3201494890 hasConceptScore W3201494890C121608353 @default.
- W3201494890 hasConceptScore W3201494890C126322002 @default.
- W3201494890 hasConceptScore W3201494890C142724271 @default.
- W3201494890 hasConceptScore W3201494890C143998085 @default.
- W3201494890 hasConceptScore W3201494890C167135981 @default.
- W3201494890 hasConceptScore W3201494890C197934379 @default.
- W3201494890 hasConceptScore W3201494890C2777407522 @default.
- W3201494890 hasConceptScore W3201494890C2777701055 @default.
- W3201494890 hasConceptScore W3201494890C2780030458 @default.
- W3201494890 hasConceptScore W3201494890C44249647 @default.
- W3201494890 hasConceptScore W3201494890C71924100 @default.
- W3201494890 hasIssue "1" @default.
- W3201494890 hasLocation W32014948901 @default.
- W3201494890 hasLocation W32014948902 @default.
- W3201494890 hasLocation W32014948903 @default.
- W3201494890 hasOpenAccess W3201494890 @default.
- W3201494890 hasPrimaryLocation W32014948901 @default.
- W3201494890 hasRelatedWork W2081773521 @default.
- W3201494890 hasRelatedWork W2518309888 @default.
- W3201494890 hasRelatedWork W2883883465 @default.
- W3201494890 hasRelatedWork W2898395149 @default.
- W3201494890 hasRelatedWork W2970332705 @default.
- W3201494890 hasRelatedWork W3006756187 @default.
- W3201494890 hasRelatedWork W3128798441 @default.
- W3201494890 hasRelatedWork W3201494890 @default.
- W3201494890 hasRelatedWork W4239217270 @default.
- W3201494890 hasRelatedWork W4302292908 @default.
- W3201494890 hasVolume "21" @default.
- W3201494890 isParatext "false" @default.
- W3201494890 isRetracted "false" @default.
- W3201494890 magId "3201494890" @default.
- W3201494890 workType "article" @default.