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- W3201501868 abstract "Humoral immunity is crucial for an efficient host immune response against rabies virus (RABV) infection. But the B cell receptor (BCR) repertoire in human after RABV vaccine immunization remained unclear. To study the BCR repertoires in peripheral blood mononuclear cells (PBMCs) of human immunized with rabies virus vaccine. In this study, we conducted BCR complementarity determining region 3 (CDR3) repertoires in 4 healthy volunteers before and after immunization with RABV vaccine by high-throughput sequencing. The bioinformatics analysis process was performed. The results showed that RABV vaccination changed the BCR diversity and the usage of V/J gene segments, as well as V-J pairing. B cell clone expansion was induced by the vaccination and sequences of high expand CDR3 aa clones were identified. To the best of our knowledge, we firstly quantitative characterized B cell receptor repertoire of human immunized with c rabies virus vaccine. It might provide us with new insights into B cell receptor condition after RABV vaccination." @default.
- W3201501868 created "2021-09-27" @default.
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- W3201501868 date "2021-08-03" @default.
- W3201501868 modified "2023-09-27" @default.
- W3201501868 title "Quantitative characterization of the B cell receptor repertoires of human immunized with commercial rabies virus vaccine" @default.
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- W3201501868 doi "https://doi.org/10.1080/21645515.2021.1893576" @default.
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