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• W3201514622 startingPage "1377" @default.
• W3201514622 abstract "Aim: The aim of our work is to aggregate data from publications of cerebrospinal fluid extracellular miRNA to identify candidate diagnostic biomarkers, and those warranting further study. Materials & methods: Data were pooled from nine studies, encompassing 864 patients across 16 diseases. Unsupervised clustering grouped patients by a broad category of diseases. Results & conclusion: Compared with healthy controls, in patients with Alzheimer's disease, hsa-miR-767-5p was overexpressed (p < 0.001) and in patients with Huntington's disease, hsa-miR-361-3p was underexpressed (p < 10-4). We also define a subset of extracellular miRNA as candidate biomarkers that are robustly detected across patients, studies and diseases; thereby, warranting further study." @default.
• W3201514622 created "2021-09-27" @default.
• W3201514622 creator A5044648533 @default.
• W3201514622 date "2021-10-01" @default.
• W3201514622 modified "2023-10-17" @default.
• W3201514622 title "Extracellular miRNA biomarkers in neurologic disease: is cerebrospinal fluid helpful?" @default.
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• W3201514622 doi "https://doi.org/10.2217/bmm-2021-0092" @default.
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