Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201516614> ?p ?o ?g. }
- W3201516614 endingPage "4110" @default.
- W3201516614 startingPage "4110" @default.
- W3201516614 abstract "(1) Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is one of the most studied rhinological disorders. Modifications of the respiratory nasal mucosa in COVID-19 patients are so far unknown. This paper presents a comparative morphological characterization of the respiratory nasal mucosa in CRSwNP versus COVID-19 and tissue interleukin (IL)-33 concentration. (2) Methods: We analyzed CRSwNP and COVID-19 samples through histopathology, scanning and transmission electron microscopy and performed proteomic determination of IL-33. (3) Results: Histopathologically, stromal edema (p < 0.0001) and basal membrane thickening (p = 0.0768) were found more frequently in CRSwNP than in COVID-19. Inflammatory infiltrate was mainly eosinophil-dominant in CRSwNP and lymphocyte-dominant in COVID-19 (p = 0.3666). A viral cytopathic effect was identified in COVID-19. Scanning electron microscopy detected biofilms only in CRSwNP, while most COVID-19 samples showed microbial aggregates (p = 0.0148) and immune cells (p = 0.1452). Transmission electron microscopy of CRSwNP samples identified biofilms, mucous cell hyperplasia (p = 0.0011), eosinophils, fibrocytes, mastocytes, and collagen fibers. Extracellular suggestive structures for SARS-CoV-2 and multiple Golgi apparatus in epithelial cells were detected in COVID-19 samples. The tissue IL-33 concentration in CRSwNP (210.0 pg/7 μg total protein) was higher than in COVID-19 (52.77 pg/7 μg total protein) (p < 0.0001), also suggesting a different inflammatory pattern. (4) Conclusions: The inflammatory pattern is different in each of these disorders. Results suggested the presence of nasal dysbiosis in both conditions, which could be a determining factor in CRSwNP and a secondary factor in COVID-19." @default.
- W3201516614 created "2021-09-27" @default.
- W3201516614 creator A5005222889 @default.
- W3201516614 creator A5009742035 @default.
- W3201516614 creator A5011315488 @default.
- W3201516614 creator A5014581424 @default.
- W3201516614 creator A5026971337 @default.
- W3201516614 creator A5028714061 @default.
- W3201516614 creator A5028826200 @default.
- W3201516614 creator A5029560113 @default.
- W3201516614 creator A5038259032 @default.
- W3201516614 creator A5048058616 @default.
- W3201516614 creator A5061430877 @default.
- W3201516614 creator A5068029947 @default.
- W3201516614 creator A5069395981 @default.
- W3201516614 creator A5077179243 @default.
- W3201516614 creator A5082711891 @default.
- W3201516614 creator A5083376943 @default.
- W3201516614 creator A5085523792 @default.
- W3201516614 creator A5085935566 @default.
- W3201516614 date "2021-09-12" @default.
- W3201516614 modified "2023-10-18" @default.
- W3201516614 title "Respiratory Nasal Mucosa in Chronic Rhinosinusitis with Nasal Polyps versus COVID-19: Histopathology, Electron Microscopy Analysis and Assessing of Tissue Interleukin-33" @default.
- W3201516614 cites W1661544713 @default.
- W3201516614 cites W1790713649 @default.
- W3201516614 cites W1841423094 @default.
- W3201516614 cites W1872307981 @default.
- W3201516614 cites W1960778855 @default.
- W3201516614 cites W1964321174 @default.
- W3201516614 cites W2000949621 @default.
- W3201516614 cites W2005120878 @default.
- W3201516614 cites W2019903015 @default.
- W3201516614 cites W2033899673 @default.
- W3201516614 cites W2039703232 @default.
- W3201516614 cites W2039756789 @default.
- W3201516614 cites W2062207460 @default.
- W3201516614 cites W2075657590 @default.
- W3201516614 cites W2077462516 @default.
- W3201516614 cites W2095311591 @default.
- W3201516614 cites W2101363729 @default.
- W3201516614 cites W2152692480 @default.
- W3201516614 cites W2153434593 @default.
- W3201516614 cites W2159015194 @default.
- W3201516614 cites W2164153769 @default.
- W3201516614 cites W2289410164 @default.
- W3201516614 cites W2521483984 @default.
- W3201516614 cites W2534692380 @default.
- W3201516614 cites W2555364178 @default.
- W3201516614 cites W2624386006 @default.
- W3201516614 cites W2650933963 @default.
- W3201516614 cites W2759778747 @default.
- W3201516614 cites W2770692169 @default.
- W3201516614 cites W2779261498 @default.
- W3201516614 cites W2886175935 @default.
- W3201516614 cites W2892046700 @default.
- W3201516614 cites W2896766242 @default.
- W3201516614 cites W2900535696 @default.
- W3201516614 cites W2936050665 @default.
- W3201516614 cites W2940871995 @default.
- W3201516614 cites W2957061427 @default.
- W3201516614 cites W2967106482 @default.
- W3201516614 cites W2983771586 @default.
- W3201516614 cites W2993136217 @default.
- W3201516614 cites W3001118548 @default.
- W3201516614 cites W3006961006 @default.
- W3201516614 cites W3009076370 @default.
- W3201516614 cites W3009906937 @default.
- W3201516614 cites W3010745071 @default.
- W3201516614 cites W3010941022 @default.
- W3201516614 cites W3013843138 @default.
- W3201516614 cites W3030748957 @default.
- W3201516614 cites W3034076191 @default.
- W3201516614 cites W3038134106 @default.
- W3201516614 cites W3040794949 @default.
- W3201516614 cites W3043155088 @default.
- W3201516614 cites W3043654491 @default.
- W3201516614 cites W3046653645 @default.
- W3201516614 cites W3047208380 @default.
- W3201516614 cites W3048373952 @default.
- W3201516614 cites W3080981445 @default.
- W3201516614 cites W3082749806 @default.
- W3201516614 cites W3082919453 @default.
- W3201516614 cites W3083852020 @default.
- W3201516614 cites W3084315869 @default.
- W3201516614 cites W3086561721 @default.
- W3201516614 cites W3089253749 @default.
- W3201516614 cites W3090786083 @default.
- W3201516614 cites W3090792849 @default.
- W3201516614 cites W3092387456 @default.
- W3201516614 cites W3095153958 @default.
- W3201516614 cites W3106646965 @default.
- W3201516614 cites W3106791064 @default.
- W3201516614 cites W3110703655 @default.
- W3201516614 cites W3119553869 @default.
- W3201516614 cites W3124825704 @default.
- W3201516614 cites W3128682615 @default.
- W3201516614 cites W3135665891 @default.
- W3201516614 cites W3143704300 @default.