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• W3201521086 endingPage "109033" @default.
• W3201521086 startingPage "109033" @default.
• W3201521086 abstract "The N-terminal 17-residue stretch of huntingtin (httN17) folds into an amphipathic α-helix. The httN17–harboring polyQ peptides form oligomers that are mediated via the assembly of the httN17 α-helices. The oligomerization results in higher local concentration of the polyglutamine (polyQ) region, thereby facilitating amyloid formation. The httN17 co-assembles with the httN17-harbouring polyQ peptides, thereby reducing the local polyQ concentration, and consequently inhibiting aggregation. This study presents the aggregation inhibition of the exon I region of pathogenic huntingtin by httN17 and its analogs. The C-terminal amidation of httN17 is found to be essential for activity. The httN17 peptides with free amino terminus and the acetylated amino terminus possess comparable activity. The httN17 analog, wherein the Leu7 and Ala10 are substituted with 2-aminoisobutyric acid residues, exhibits significantly higher activity than the native httN17." @default.
• W3201521086 created "2021-09-27" @default.
• W3201521086 creator A5005961179 @default.
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• W3201521086 date "2021-11-01" @default.
• W3201521086 modified "2023-09-28" @default.
• W3201521086 title "Inhibition of huntingtin aggregation by its N-terminal 17-residue peptide and its analogs" @default.
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• W3201521086 doi "https://doi.org/10.1016/j.abb.2021.109033" @default.
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