Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201524301> ?p ?o ?g. }
- W3201524301 endingPage "64" @default.
- W3201524301 startingPage "53" @default.
- W3201524301 abstract "Abstract Acute liver injury (ALI) is characterized by apoptosis, inflammation, and oxidative stress, and pathogenic mechanism of ALI is poorly understood. Apoptosis-stimulating of p53 protein 1 (ASPP1) is involved in environmental responses, tumor growth, and NF- K B activity, which is of critical importance to ALI. However, the role of ASPP1 in ALI remains largely unexplored. The current study aimed to determine the role of ASPP1 in ALI induced by CCl4 and the underlying mechanism. ASPP1 expression was detected in wild type (WT) mice with ALI induced by CCl4. The function of ASPP1 in ALI induced by CCl4 was investigated using conventional knockout ASPP1 mice. ASPP1 expression significantly increased in ALI mice at 24 hours after CCl4 injection. Deletion of ASSP1 ameliorated apoptosis, inflammation, and necrosis in ALI relative to WT mice. In addition, deficiency of ASPP1 improved liver flood flow as well as ALT and AST levels. The levels of phosphorylated p65 and phosphorylated IκBα were lower in ASPP1-/- mice than in WT mice with ALI. These results implicate that deletion of ASPP1 may act via inhibition of the NF-κB pathway and protect mice from ALI, which may be a new potential therapeutic target for the treatment of ALI." @default.
- W3201524301 created "2021-09-27" @default.
- W3201524301 creator A5007704127 @default.
- W3201524301 creator A5010019504 @default.
- W3201524301 creator A5019520760 @default.
- W3201524301 creator A5032003836 @default.
- W3201524301 creator A5036961681 @default.
- W3201524301 creator A5039357783 @default.
- W3201524301 creator A5048700726 @default.
- W3201524301 creator A5055871147 @default.
- W3201524301 creator A5061287436 @default.
- W3201524301 creator A5064738683 @default.
- W3201524301 creator A5080186293 @default.
- W3201524301 date "2021-09-01" @default.
- W3201524301 modified "2023-10-16" @default.
- W3201524301 title "Ablation of apoptosis-stimulating of p53 protein 1 protects mice from acute hepatic injury and dysfunction via NF-κB pathway in CCl4-induced hepatotoxicity" @default.
- W3201524301 cites W1967795278 @default.
- W3201524301 cites W1977695193 @default.
- W3201524301 cites W1982349773 @default.
- W3201524301 cites W2008913148 @default.
- W3201524301 cites W2027306434 @default.
- W3201524301 cites W2028815386 @default.
- W3201524301 cites W2044043514 @default.
- W3201524301 cites W2045149931 @default.
- W3201524301 cites W2049466717 @default.
- W3201524301 cites W2062462914 @default.
- W3201524301 cites W2073882423 @default.
- W3201524301 cites W2081803191 @default.
- W3201524301 cites W2087732778 @default.
- W3201524301 cites W2094863064 @default.
- W3201524301 cites W2096009885 @default.
- W3201524301 cites W2115692333 @default.
- W3201524301 cites W2116201088 @default.
- W3201524301 cites W2153780024 @default.
- W3201524301 cites W2179561346 @default.
- W3201524301 cites W2325596649 @default.
- W3201524301 cites W2347152249 @default.
- W3201524301 cites W2598200020 @default.
- W3201524301 cites W2623791303 @default.
- W3201524301 cites W2725303335 @default.
- W3201524301 cites W2739384211 @default.
- W3201524301 cites W2749828448 @default.
- W3201524301 cites W2766128433 @default.
- W3201524301 cites W2800295319 @default.
- W3201524301 cites W2804653623 @default.
- W3201524301 cites W2808768761 @default.
- W3201524301 cites W2884534635 @default.
- W3201524301 cites W2901166031 @default.
- W3201524301 cites W2922988017 @default.
- W3201524301 cites W2944605639 @default.
- W3201524301 cites W2962760627 @default.
- W3201524301 cites W2972939056 @default.
- W3201524301 cites W2986278503 @default.
- W3201524301 cites W4206609475 @default.
- W3201524301 cites W4237789900 @default.
- W3201524301 doi "https://doi.org/10.2478/fzm-2021-0007" @default.
- W3201524301 hasPublicationYear "2021" @default.
- W3201524301 type Work @default.
- W3201524301 sameAs 3201524301 @default.
- W3201524301 citedByCount "1" @default.
- W3201524301 countsByYear W32015243012023 @default.
- W3201524301 crossrefType "journal-article" @default.
- W3201524301 hasAuthorship W3201524301A5007704127 @default.
- W3201524301 hasAuthorship W3201524301A5010019504 @default.
- W3201524301 hasAuthorship W3201524301A5019520760 @default.
- W3201524301 hasAuthorship W3201524301A5032003836 @default.
- W3201524301 hasAuthorship W3201524301A5036961681 @default.
- W3201524301 hasAuthorship W3201524301A5039357783 @default.
- W3201524301 hasAuthorship W3201524301A5048700726 @default.
- W3201524301 hasAuthorship W3201524301A5055871147 @default.
- W3201524301 hasAuthorship W3201524301A5061287436 @default.
- W3201524301 hasAuthorship W3201524301A5064738683 @default.
- W3201524301 hasAuthorship W3201524301A5080186293 @default.
- W3201524301 hasBestOaLocation W32015243011 @default.
- W3201524301 hasConcept C102124568 @default.
- W3201524301 hasConcept C11960822 @default.
- W3201524301 hasConcept C126322002 @default.
- W3201524301 hasConcept C134018914 @default.
- W3201524301 hasConcept C170493617 @default.
- W3201524301 hasConcept C178790620 @default.
- W3201524301 hasConcept C17991360 @default.
- W3201524301 hasConcept C182704531 @default.
- W3201524301 hasConcept C185592680 @default.
- W3201524301 hasConcept C190283241 @default.
- W3201524301 hasConcept C203014093 @default.
- W3201524301 hasConcept C2776151105 @default.
- W3201524301 hasConcept C2776914184 @default.
- W3201524301 hasConcept C2777359374 @default.
- W3201524301 hasConcept C2777730290 @default.
- W3201524301 hasConcept C502942594 @default.
- W3201524301 hasConcept C55493867 @default.
- W3201524301 hasConcept C71924100 @default.
- W3201524301 hasConcept C98274493 @default.
- W3201524301 hasConceptScore W3201524301C102124568 @default.
- W3201524301 hasConceptScore W3201524301C11960822 @default.
- W3201524301 hasConceptScore W3201524301C126322002 @default.
- W3201524301 hasConceptScore W3201524301C134018914 @default.
- W3201524301 hasConceptScore W3201524301C170493617 @default.