Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201524805> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W3201524805 abstract "Chemotherapeutic agents can impair gonadal function triggering infertility. Here, we probed the properties of carnosine as an antioxidant in reproductive disorders caused by the combination of cyclophosphamide, hydroxydaunomycin (doxorubicin), oncovin (vincristine) and prednisone (CHOP); this combination is mostly used in treating non-Hodgkin lymphoma. Animals were distributed into four groups: Group I was the control. Group II received carnosine (250mg kg day-1 , i.p.); Group III received CHOP: cyclophosphamide (27 mg/kg/cycle), doxorubicin (1.8 mg/kg/cycle) and vincristine (0.05 mg/kg /cycle) by i.p. plus oral prednisone (1.47 mg kg-1 day-1 /cycle) for five days. Group IV received carnosine plus CHOP. The study involved 4 cycles each of 3 weeks. Also, we explored the effect of combining carnosine with CHOP on the development of solid Ehrlich carcinoma in mice. CHOP lowered genitals weight, sperm count and motility, testicular function marker enzymes, serum testosterone level and gene expression of 3β-hydroxysteroid dehydrogenase, 17β-hydroxysteroid dehydrogenase and steroidogenic acute regulatory protein. Furthermore, CHOP elevated testicular oxidative stress, serum follicle-stimulating hormone, luteinising hormone and triggered DNA damage. Morphometric and histopathological examinations of testicular tissues buttressed the biochemical results. Importantly, administration of carnosine ameliorated CHOP-induced alterations without diminishing CHOP's antineoplastic action. These results indicated that carnosine may ameliorate reproductive disorders induced by CHOP." @default.
- W3201524805 created "2021-09-27" @default.
- W3201524805 creator A5011350236 @default.
- W3201524805 creator A5011440961 @default.
- W3201524805 creator A5030522897 @default.
- W3201524805 creator A5048379757 @default.
- W3201524805 date "2021-09-18" @default.
- W3201524805 modified "2023-09-27" @default.
- W3201524805 title "Carnosine Remedial Effect on Fertility of Male Rats Receiving Cyclophosphamide, Hydroxydaunomycin, Oncovin and Prednisone (CHOP)" @default.
- W3201524805 cites W1161717916 @default.
- W3201524805 cites W1775749144 @default.
- W3201524805 cites W1855486821 @default.
- W3201524805 cites W1966541444 @default.
- W3201524805 cites W1967569950 @default.
- W3201524805 cites W1978425989 @default.
- W3201524805 cites W1981572999 @default.
- W3201524805 cites W1983285991 @default.
- W3201524805 cites W1990609274 @default.
- W3201524805 cites W1992270775 @default.
- W3201524805 cites W1993909890 @default.
- W3201524805 cites W1996175028 @default.
- W3201524805 cites W2001209487 @default.
- W3201524805 cites W2010183849 @default.
- W3201524805 cites W2034561887 @default.
- W3201524805 cites W2037257181 @default.
- W3201524805 cites W2053054955 @default.
- W3201524805 cites W2062852595 @default.
- W3201524805 cites W2065835296 @default.
- W3201524805 cites W2069527371 @default.
- W3201524805 cites W2079091273 @default.
- W3201524805 cites W2085141969 @default.
- W3201524805 cites W2087324712 @default.
- W3201524805 cites W2087490881 @default.
- W3201524805 cites W2092574032 @default.
- W3201524805 cites W2092629964 @default.
- W3201524805 cites W2094628752 @default.
- W3201524805 cites W2100802828 @default.
- W3201524805 cites W2108244474 @default.
- W3201524805 cites W2111370164 @default.
- W3201524805 cites W2120821606 @default.
- W3201524805 cites W2140097914 @default.
- W3201524805 cites W2157475701 @default.
- W3201524805 cites W2168110316 @default.
- W3201524805 cites W2168220191 @default.
- W3201524805 cites W2329337807 @default.
- W3201524805 cites W2904496381 @default.
- W3201524805 cites W2922006436 @default.
- W3201524805 cites W3012027308 @default.
- W3201524805 cites W4247747154 @default.
- W3201524805 cites W75919489 @default.
- W3201524805 doi "https://doi.org/10.1111/and.14233" @default.
- W3201524805 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34535909" @default.
- W3201524805 hasPublicationYear "2021" @default.
- W3201524805 type Work @default.
- W3201524805 sameAs 3201524805 @default.
- W3201524805 citedByCount "0" @default.
- W3201524805 crossrefType "journal-article" @default.
- W3201524805 hasAuthorship W3201524805A5011350236 @default.
- W3201524805 hasAuthorship W3201524805A5011440961 @default.
- W3201524805 hasAuthorship W3201524805A5030522897 @default.
- W3201524805 hasAuthorship W3201524805A5048379757 @default.
- W3201524805 hasBestOaLocation W32015248051 @default.
- W3201524805 hasConcept C126322002 @default.
- W3201524805 hasConcept C134018914 @default.
- W3201524805 hasConcept C2776694085 @default.
- W3201524805 hasConcept C2776755627 @default.
- W3201524805 hasConcept C2778720950 @default.
- W3201524805 hasConcept C2779429289 @default.
- W3201524805 hasConcept C2779725641 @default.
- W3201524805 hasConcept C71924100 @default.
- W3201524805 hasConcept C98274493 @default.
- W3201524805 hasConceptScore W3201524805C126322002 @default.
- W3201524805 hasConceptScore W3201524805C134018914 @default.
- W3201524805 hasConceptScore W3201524805C2776694085 @default.
- W3201524805 hasConceptScore W3201524805C2776755627 @default.
- W3201524805 hasConceptScore W3201524805C2778720950 @default.
- W3201524805 hasConceptScore W3201524805C2779429289 @default.
- W3201524805 hasConceptScore W3201524805C2779725641 @default.
- W3201524805 hasConceptScore W3201524805C71924100 @default.
- W3201524805 hasConceptScore W3201524805C98274493 @default.
- W3201524805 hasIssue "11" @default.
- W3201524805 hasLocation W32015248051 @default.
- W3201524805 hasLocation W32015248052 @default.
- W3201524805 hasOpenAccess W3201524805 @default.
- W3201524805 hasPrimaryLocation W32015248051 @default.
- W3201524805 hasRelatedWork W160156331 @default.
- W3201524805 hasRelatedWork W1965180444 @default.
- W3201524805 hasRelatedWork W1970150235 @default.
- W3201524805 hasRelatedWork W2007345078 @default.
- W3201524805 hasRelatedWork W2044885796 @default.
- W3201524805 hasRelatedWork W2058154950 @default.
- W3201524805 hasRelatedWork W2087824134 @default.
- W3201524805 hasRelatedWork W2093194444 @default.
- W3201524805 hasRelatedWork W2253448891 @default.
- W3201524805 hasRelatedWork W2353496484 @default.
- W3201524805 hasVolume "53" @default.
- W3201524805 isParatext "false" @default.
- W3201524805 isRetracted "false" @default.
- W3201524805 magId "3201524805" @default.
- W3201524805 workType "article" @default.