Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201530379> ?p ?o ?g. }
- W3201530379 abstract "Adverse myocardial remodeling, manifesting pathologically as myocardial hypertrophy and fibrosis, often follows myocardial infarction (MI) and results in cardiac dysfunction. In this study, an obvious epicardial adipose tissue (EAT) was observed in the rat model of MI and the EAT weights were positively correlated with cardiomyocyte size and myocardial fibrosis areas in the MI 2- and 4-week groups. Then, rat cardiomyocyte cell line H9C2 and primary rat cardiac fibroblasts were cultured in conditioned media generated from EAT of rats in the MI 4-week group (EAT-CM). Functionally, EAT-CM enlarged the cell surface area of H9C2 cells and reinforced cardiac fibroblast activation into myofibroblasts by elevating intracellular reactive oxygen species (ROS) levels. Mechanistically, miR-134-5p was upregulated by EAT-CM in both H9C2 cells and primary rat cardiac fibroblasts. miR-134-5p knockdown promoted histone H3K14 acetylation of manganese superoxide dismutase and catalase by upregulating lysine acetyltransferase 7 expression, thereby decreasing ROS level. An in vivo study showed that miR-134-5p knockdown limited adverse myocardial remodeling in the rat model of MI, manifesting as alleviation of cardiomyocyte hypertrophy and fibrosis. In general, our study clarified a new pathological mechanism involving an EAT/miRNA axis that explains the adverse myocardial remodeling occurring after MI." @default.
- W3201530379 created "2021-09-27" @default.
- W3201530379 creator A5012934231 @default.
- W3201530379 creator A5013028740 @default.
- W3201530379 creator A5043233370 @default.
- W3201530379 creator A5048649554 @default.
- W3201530379 creator A5050739506 @default.
- W3201530379 creator A5057070855 @default.
- W3201530379 creator A5063106321 @default.
- W3201530379 date "2021-09-13" @default.
- W3201530379 modified "2023-10-08" @default.
- W3201530379 title "Secretory products from epicardial adipose tissue induce adverse myocardial remodeling after myocardial infarction by promoting reactive oxygen species accumulation" @default.
- W3201530379 cites W1994859901 @default.
- W3201530379 cites W2045282711 @default.
- W3201530379 cites W2098267336 @default.
- W3201530379 cites W2111880045 @default.
- W3201530379 cites W2129951067 @default.
- W3201530379 cites W2147653980 @default.
- W3201530379 cites W2258307956 @default.
- W3201530379 cites W2291200357 @default.
- W3201530379 cites W2470437549 @default.
- W3201530379 cites W2546877739 @default.
- W3201530379 cites W2556942741 @default.
- W3201530379 cites W2567923794 @default.
- W3201530379 cites W2586151637 @default.
- W3201530379 cites W2589529938 @default.
- W3201530379 cites W2600426893 @default.
- W3201530379 cites W2604322274 @default.
- W3201530379 cites W2749339865 @default.
- W3201530379 cites W2762575048 @default.
- W3201530379 cites W2766926061 @default.
- W3201530379 cites W2800935991 @default.
- W3201530379 cites W2892528668 @default.
- W3201530379 cites W2897233775 @default.
- W3201530379 cites W2929823585 @default.
- W3201530379 cites W2934950746 @default.
- W3201530379 cites W2936460976 @default.
- W3201530379 cites W2951807991 @default.
- W3201530379 cites W2959363312 @default.
- W3201530379 cites W2969499723 @default.
- W3201530379 cites W2969685486 @default.
- W3201530379 cites W2980659226 @default.
- W3201530379 cites W2982246887 @default.
- W3201530379 cites W2983214941 @default.
- W3201530379 cites W2991633412 @default.
- W3201530379 cites W3007043861 @default.
- W3201530379 cites W3042056195 @default.
- W3201530379 cites W3043741280 @default.
- W3201530379 cites W3110213240 @default.
- W3201530379 cites W3114125476 @default.
- W3201530379 cites W4211143906 @default.
- W3201530379 doi "https://doi.org/10.1038/s41419-021-04111-x" @default.
- W3201530379 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8438091" @default.
- W3201530379 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34518516" @default.
- W3201530379 hasPublicationYear "2021" @default.
- W3201530379 type Work @default.
- W3201530379 sameAs 3201530379 @default.
- W3201530379 citedByCount "18" @default.
- W3201530379 countsByYear W32015303792022 @default.
- W3201530379 countsByYear W32015303792023 @default.
- W3201530379 crossrefType "journal-article" @default.
- W3201530379 hasAuthorship W3201530379A5012934231 @default.
- W3201530379 hasAuthorship W3201530379A5013028740 @default.
- W3201530379 hasAuthorship W3201530379A5043233370 @default.
- W3201530379 hasAuthorship W3201530379A5048649554 @default.
- W3201530379 hasAuthorship W3201530379A5050739506 @default.
- W3201530379 hasAuthorship W3201530379A5057070855 @default.
- W3201530379 hasAuthorship W3201530379A5063106321 @default.
- W3201530379 hasBestOaLocation W32015303791 @default.
- W3201530379 hasConcept C104317684 @default.
- W3201530379 hasConcept C126322002 @default.
- W3201530379 hasConcept C127561419 @default.
- W3201530379 hasConcept C134018914 @default.
- W3201530379 hasConcept C164705383 @default.
- W3201530379 hasConcept C173396325 @default.
- W3201530379 hasConcept C185592680 @default.
- W3201530379 hasConcept C190283241 @default.
- W3201530379 hasConcept C207865475 @default.
- W3201530379 hasConcept C2777420927 @default.
- W3201530379 hasConcept C2779537366 @default.
- W3201530379 hasConcept C2780559512 @default.
- W3201530379 hasConcept C3018763269 @default.
- W3201530379 hasConcept C48349386 @default.
- W3201530379 hasConcept C500558357 @default.
- W3201530379 hasConcept C55493867 @default.
- W3201530379 hasConcept C71924100 @default.
- W3201530379 hasConcept C86803240 @default.
- W3201530379 hasConcept C95444343 @default.
- W3201530379 hasConceptScore W3201530379C104317684 @default.
- W3201530379 hasConceptScore W3201530379C126322002 @default.
- W3201530379 hasConceptScore W3201530379C127561419 @default.
- W3201530379 hasConceptScore W3201530379C134018914 @default.
- W3201530379 hasConceptScore W3201530379C164705383 @default.
- W3201530379 hasConceptScore W3201530379C173396325 @default.
- W3201530379 hasConceptScore W3201530379C185592680 @default.
- W3201530379 hasConceptScore W3201530379C190283241 @default.
- W3201530379 hasConceptScore W3201530379C207865475 @default.
- W3201530379 hasConceptScore W3201530379C2777420927 @default.
- W3201530379 hasConceptScore W3201530379C2779537366 @default.
- W3201530379 hasConceptScore W3201530379C2780559512 @default.