Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201531650> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W3201531650 endingPage "e422" @default.
- W3201531650 startingPage "e422" @default.
- W3201531650 abstract "The present study aimed to assess the effect of Hedgehog pathway inhibitors (SMO-LDE225 and GLI-Gant61) as a therapeutic option in the xenograft model of uterine LMS. 29 nu/nu nude mice were used and the mice were handled according to the approved protocol (18-174). 2x107 of the human LMS cells were inoculated into the right flank of mice. After the tumor development, the animals were randomized separately into three groups, SMO inhibitor LDE225 (n=5), GLI inhibitor Gant61 (n=12), and control (n=12). 20 mg/kg of LDE225, 20 mg/kg of Gant61, or corn oil (vehicle) were administrated via oral gavage three times per week for 10 days to the Gant61 group and 21 days to the LDE225 group. After the treatment, the animals were sacrificed, and tumors were collected for histopathological, RNA, and protein expression profile analysis. Statistical analyses were performed using GraphPad Prism 5 Software and the significant difference was defined as p<0.05. The results demonstrated that LDE225 treatment did not show any inhibitory effect on LMS tumor growth, however, treatment with, GLI inhibitor (Gant61) induced a remarkable tumor regression with a significant decrease in Ki67 expression, compared to control (p<0.01). Moreover, administration of Gant61 decreased the expression of GLI1, GLI target genes BMP4 and c-MYC (p<0.05), indicating that the HH pathway is implicated in the LMS experimental model. Our study demonstrates for the first time that GLI inhibitor (Gant61), but not SMO inhibitor (LDE225), shows a potent inhibitory effect on LMS tumor growth and concomitantly suppresses the expression of GLI1 and GLI-targeted genes using the xenograft model of uterine LMS." @default.
- W3201531650 created "2021-09-27" @default.
- W3201531650 creator A5000361113 @default.
- W3201531650 creator A5003343672 @default.
- W3201531650 creator A5048095058 @default.
- W3201531650 creator A5059401832 @default.
- W3201531650 creator A5078201457 @default.
- W3201531650 creator A5090356906 @default.
- W3201531650 date "2021-09-01" @default.
- W3201531650 modified "2023-09-29" @default.
- W3201531650 title "EVALUATION OF HEDGEHOG PATHWAY INHIBITORS AS A THERAPEUTIC OPTION FOR UTERINE LEIOMYOSARCOMA USING THE XENOGRAFT MODEL" @default.
- W3201531650 doi "https://doi.org/10.1016/j.fertnstert.2021.07.1128" @default.
- W3201531650 hasPublicationYear "2021" @default.
- W3201531650 type Work @default.
- W3201531650 sameAs 3201531650 @default.
- W3201531650 citedByCount "0" @default.
- W3201531650 crossrefType "journal-article" @default.
- W3201531650 hasAuthorship W3201531650A5000361113 @default.
- W3201531650 hasAuthorship W3201531650A5003343672 @default.
- W3201531650 hasAuthorship W3201531650A5048095058 @default.
- W3201531650 hasAuthorship W3201531650A5059401832 @default.
- W3201531650 hasAuthorship W3201531650A5078201457 @default.
- W3201531650 hasAuthorship W3201531650A5090356906 @default.
- W3201531650 hasBestOaLocation W32015316501 @default.
- W3201531650 hasConcept C126322002 @default.
- W3201531650 hasConcept C126894567 @default.
- W3201531650 hasConcept C143998085 @default.
- W3201531650 hasConcept C145837895 @default.
- W3201531650 hasConcept C16685009 @default.
- W3201531650 hasConcept C2778539099 @default.
- W3201531650 hasConcept C2779933373 @default.
- W3201531650 hasConcept C55493867 @default.
- W3201531650 hasConcept C62478195 @default.
- W3201531650 hasConcept C71924100 @default.
- W3201531650 hasConcept C86803240 @default.
- W3201531650 hasConcept C88498014 @default.
- W3201531650 hasConcept C98274493 @default.
- W3201531650 hasConceptScore W3201531650C126322002 @default.
- W3201531650 hasConceptScore W3201531650C126894567 @default.
- W3201531650 hasConceptScore W3201531650C143998085 @default.
- W3201531650 hasConceptScore W3201531650C145837895 @default.
- W3201531650 hasConceptScore W3201531650C16685009 @default.
- W3201531650 hasConceptScore W3201531650C2778539099 @default.
- W3201531650 hasConceptScore W3201531650C2779933373 @default.
- W3201531650 hasConceptScore W3201531650C55493867 @default.
- W3201531650 hasConceptScore W3201531650C62478195 @default.
- W3201531650 hasConceptScore W3201531650C71924100 @default.
- W3201531650 hasConceptScore W3201531650C86803240 @default.
- W3201531650 hasConceptScore W3201531650C88498014 @default.
- W3201531650 hasConceptScore W3201531650C98274493 @default.
- W3201531650 hasIssue "3" @default.
- W3201531650 hasLocation W32015316501 @default.
- W3201531650 hasOpenAccess W3201531650 @default.
- W3201531650 hasPrimaryLocation W32015316501 @default.
- W3201531650 hasRelatedWork W1529799967 @default.
- W3201531650 hasRelatedWork W1989313612 @default.
- W3201531650 hasRelatedWork W2128670495 @default.
- W3201531650 hasRelatedWork W2340441163 @default.
- W3201531650 hasRelatedWork W2773386546 @default.
- W3201531650 hasRelatedWork W3125075261 @default.
- W3201531650 hasRelatedWork W3201051655 @default.
- W3201531650 hasRelatedWork W4308977430 @default.
- W3201531650 hasRelatedWork W1934545107 @default.
- W3201531650 hasRelatedWork W2153559483 @default.
- W3201531650 hasVolume "116" @default.
- W3201531650 isParatext "false" @default.
- W3201531650 isRetracted "false" @default.
- W3201531650 magId "3201531650" @default.
- W3201531650 workType "article" @default.