FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201535919> ?p ?o ?g. }

• W3201535919 abstract "Abstract Memory retention and transfer in organisms happen at either the neural or genetic level. In humans, addictive behavior is known to pass from parents to offspring. In flatworm planaria ( Dugesia tigrina ), memory transfer has been claimed to be horizontal, i.e., through cannibalism. Our study is a preliminary step to understand the mechanisms underlying the transfer of addictive behavior to offspring. Since the neural and neurochemical responses of planaria share similarities with humans, it is possible to induce addictions and get predictable behavioral responses. Addiction can be induced in planaria, and decapitation will reveal if the addictive memories are solely stored in the brain. The primary objective was to test the hypothesis that addictive memory is also retained in the brainless posterior region of planaria. The surface preference of the planaria was first determined between smooth and rough surfaces. Through Pavlovian conditioning, the preferred surface was paired with water and the unpreferred surface with sucrose. After the planaria were trained and addicted, their surface preference shifted as a conditioned place preference (CPP) was established. When decapitated, the regenerated segment from the anterior part containing the brain retained the addiction, thus maintaining a shift in the surface preference. Importantly, we observed that the posterior part preserved this CPP as well, suggesting that memory retention is not attributed exclusively to the brain but might also occur at the genetic level. As a secondary objective, the effects of neurotransmitter blocking agents in preventing addiction were studied by administering a D1 dopamine antagonist to planaria, which could provide pointers to treat addictions in humans." @default.
• W3201535919 created "2021-09-27" @default.
• W3201535919 creator A5007519420 @default.
• W3201535919 creator A5059493127 @default.
• W3201535919 creator A5064129081 @default.
• W3201535919 date "2021-09-15" @default.
• W3201535919 modified "2023-10-17" @default.
• W3201535919 title "Addiction-Related Memory Transfer and Retention in Planaria" @default.
• W3201535919 cites W1515108121 @default.
• W3201535919 cites W1964005948 @default.
• W3201535919 cites W2070780907 @default.
• W3201535919 cites W2102200323 @default.
• W3201535919 cites W2123243920 @default.
• W3201535919 cites W2130481665 @default.
• W3201535919 cites W2146280355 @default.
• W3201535919 cites W2167157984 @default.
• W3201535919 cites W2171579279 @default.
• W3201535919 cites W2274975540 @default.
• W3201535919 cites W2280826051 @default.
• W3201535919 cites W2335689782 @default.
• W3201535919 cites W2589605652 @default.
• W3201535919 cites W2751036769 @default.
• W3201535919 cites W2771180769 @default.
• W3201535919 cites W2883734802 @default.
• W3201535919 cites W2895729770 @default.
• W3201535919 cites W2900201370 @default.
• W3201535919 cites W2936516220 @default.
• W3201535919 doi "https://doi.org/10.1101/2021.09.12.459965" @default.
• W3201535919 hasPublicationYear "2021" @default.
• W3201535919 type Work @default.
• W3201535919 sameAs 3201535919 @default.
• W3201535919 citedByCount "2" @default.
• W3201535919 countsByYear W32015359192022 @default.
• W3201535919 crossrefType "posted-content" @default.
• W3201535919 hasAuthorship W3201535919A5007519420 @default.
• W3201535919 hasAuthorship W3201535919A5059493127 @default.
• W3201535919 hasAuthorship W3201535919A5064129081 @default.
• W3201535919 hasBestOaLocation W32015359191 @default.
• W3201535919 hasConcept C15744967 @default.
• W3201535919 hasConcept C169760540 @default.
• W3201535919 hasConcept C171056886 @default.
• W3201535919 hasConcept C25876315 @default.
• W3201535919 hasConcept C2777113906 @default.
• W3201535919 hasConcept C2909211665 @default.
• W3201535919 hasConcept C35124327 @default.
• W3201535919 hasConcept C48856860 @default.
• W3201535919 hasConcept C86803240 @default.
• W3201535919 hasConcept C95444343 @default.
• W3201535919 hasConceptScore W3201535919C15744967 @default.
• W3201535919 hasConceptScore W3201535919C169760540 @default.
• W3201535919 hasConceptScore W3201535919C171056886 @default.
• W3201535919 hasConceptScore W3201535919C25876315 @default.
• W3201535919 hasConceptScore W3201535919C2777113906 @default.
• W3201535919 hasConceptScore W3201535919C2909211665 @default.
• W3201535919 hasConceptScore W3201535919C35124327 @default.
• W3201535919 hasConceptScore W3201535919C48856860 @default.
• W3201535919 hasConceptScore W3201535919C86803240 @default.
• W3201535919 hasConceptScore W3201535919C95444343 @default.
• W3201535919 hasLocation W32015359191 @default.
• W3201535919 hasOpenAccess W3201535919 @default.
• W3201535919 hasPrimaryLocation W32015359191 @default.
• W3201535919 hasRelatedWork W1563714058 @default.
• W3201535919 hasRelatedWork W1981201955 @default.
• W3201535919 hasRelatedWork W2012801579 @default.
• W3201535919 hasRelatedWork W2059406298 @default.
• W3201535919 hasRelatedWork W2095889446 @default.
• W3201535919 hasRelatedWork W2346864595 @default.
• W3201535919 hasRelatedWork W2646195775 @default.
• W3201535919 hasRelatedWork W2887665570 @default.
• W3201535919 hasRelatedWork W3201535919 @default.
• W3201535919 hasRelatedWork W4240173325 @default.
• W3201535919 isParatext "false" @default.
• W3201535919 isRetracted "false" @default.
• W3201535919 magId "3201535919" @default.
• W3201535919 workType "article" @default.