FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201546315> ?p ?o ?g. }

• W3201546315 abstract "Advances in multiparametric MRI (mpMRI) combining anatomic and functional imaging can accurately identify foci of adenocarcinoma within the prostate, offering the possibility of partial gland therapy. We performed tandem prospective pilot trials to investigate the feasibility of focal prostate SBRT (f-SBRT) based on correlating diagnostic mpMRI and biopsies with confirmatory pathology in treatment planning.Patients with pathologic focal Gleason 6-7 disease and a corresponding PIRADS 4-5 lesion on mpMRI underwent targeted and comprehensive biopsies using MRI/ultrasound fusion under electromagnetic sensor navigation. After rigorous analysis for imaging biopsy concordance, five of 18 patients were eligible to proceed to f-SBRT. Chi-squared test was used for differences from expected outcomes, and concordance was estimated with binomial distribution theory and Wilson's method.Six patients had Gleason 6 and 12 had Gleason 3 + 4 disease (mean PSA: 5.8 ng/ml, range: 2.2-8.4). Absolute concordance was 43.8% (95% CI: 0.20, 0.64). Patterns of discordance included additional sites of ipsilateral disease, bilateral disease, and negative target. Five were upstaged to a new NCCN risk category necessitating treatment escalation. The five patients with concordant pathology completed three-fraction f-SBRT with sparing of the surrounding normal structures (including contralateral neurovascular bundle), with no reported grade 2+ toxicities and favorable PSA responses (mean: 41% decrease).On our pilot trials of f-SBRT planning using rigorous imaging and pathology concordance, image-guided confirmatory biopsies frequently revealed additional disease, suggesting the need for caution in partial-gland therapy. For truly focal disease, f-SBRT provided excellent dosimetry, minimal toxicity, and encouraging biochemical response. Clinical Trial Registration: www.clinicaltrials.gov, NCT02681614; NCT02163317." @default.
• W3201546315 created "2021-09-27" @default.
• W3201546315 creator A5004343685 @default.
• W3201546315 creator A5005758666 @default.
• W3201546315 creator A5009444072 @default.
• W3201546315 creator A5010531417 @default.
• W3201546315 creator A5018694224 @default.
• W3201546315 creator A5026445761 @default.
• W3201546315 creator A5038958039 @default.
• W3201546315 creator A5055633509 @default.
• W3201546315 creator A5060092069 @default.
• W3201546315 creator A5060689059 @default.
• W3201546315 creator A5090754156 @default.
• W3201546315 date "2021-09-15" @default.
• W3201546315 modified "2023-09-28" @default.
• W3201546315 title "Focal Prostate Stereotactic Body Radiation Therapy With Correlative Pathological and Radiographic-Based Treatment Planning" @default.
• W3201546315 cites W1785208601 @default.
• W3201546315 cites W1955226607 @default.
• W3201546315 cites W1971646649 @default.
• W3201546315 cites W1979387793 @default.
• W3201546315 cites W1996717357 @default.
• W3201546315 cites W1998282791 @default.
• W3201546315 cites W1998690332 @default.
• W3201546315 cites W1999615753 @default.
• W3201546315 cites W2012341987 @default.
• W3201546315 cites W2012650059 @default.
• W3201546315 cites W2037863833 @default.
• W3201546315 cites W2056153636 @default.
• W3201546315 cites W2074126836 @default.
• W3201546315 cites W2080725537 @default.
• W3201546315 cites W2106578604 @default.
• W3201546315 cites W2129841792 @default.
• W3201546315 cites W2131565955 @default.
• W3201546315 cites W2138680116 @default.
• W3201546315 cites W2164364841 @default.
• W3201546315 cites W2343439090 @default.
• W3201546315 cites W2343800472 @default.
• W3201546315 cites W2399392752 @default.
• W3201546315 cites W2535092071 @default.
• W3201546315 cites W2547150541 @default.
• W3201546315 cites W2592338623 @default.
• W3201546315 cites W2596094932 @default.
• W3201546315 cites W2724471376 @default.
• W3201546315 cites W2776781030 @default.
• W3201546315 cites W2784041986 @default.
• W3201546315 cites W2793905111 @default.
• W3201546315 cites W2809343783 @default.
• W3201546315 cites W2915254945 @default.
• W3201546315 cites W2972974117 @default.
• W3201546315 cites W2994487010 @default.
• W3201546315 cites W3041382846 @default.
• W3201546315 doi "https://doi.org/10.3389/fonc.2021.744130" @default.
• W3201546315 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8480263" @default.
• W3201546315 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34604088" @default.
• W3201546315 hasPublicationYear "2021" @default.
• W3201546315 type Work @default.
• W3201546315 sameAs 3201546315 @default.
• W3201546315 citedByCount "2" @default.
• W3201546315 countsByYear W32015463152022 @default.
• W3201546315 countsByYear W32015463152023 @default.
• W3201546315 crossrefType "journal-article" @default.
• W3201546315 hasAuthorship W3201546315A5004343685 @default.
• W3201546315 hasAuthorship W3201546315A5005758666 @default.
• W3201546315 hasAuthorship W3201546315A5009444072 @default.
• W3201546315 hasAuthorship W3201546315A5010531417 @default.
• W3201546315 hasAuthorship W3201546315A5018694224 @default.
• W3201546315 hasAuthorship W3201546315A5026445761 @default.
• W3201546315 hasAuthorship W3201546315A5038958039 @default.
• W3201546315 hasAuthorship W3201546315A5055633509 @default.
• W3201546315 hasAuthorship W3201546315A5060092069 @default.
• W3201546315 hasAuthorship W3201546315A5060689059 @default.
• W3201546315 hasAuthorship W3201546315A5090754156 @default.
• W3201546315 hasBestOaLocation W32015463151 @default.
• W3201546315 hasConcept C105572291 @default.
• W3201546315 hasConcept C118552586 @default.
• W3201546315 hasConcept C121608353 @default.
• W3201546315 hasConcept C126322002 @default.
• W3201546315 hasConcept C126838900 @default.
• W3201546315 hasConcept C142724271 @default.
• W3201546315 hasConcept C143409427 @default.
• W3201546315 hasConcept C160798450 @default.
• W3201546315 hasConcept C16568411 @default.
• W3201546315 hasConcept C2775934546 @default.
• W3201546315 hasConcept C2776235491 @default.
• W3201546315 hasConcept C2779889316 @default.
• W3201546315 hasConcept C509974204 @default.
• W3201546315 hasConcept C71924100 @default.
• W3201546315 hasConceptScore W3201546315C105572291 @default.
• W3201546315 hasConceptScore W3201546315C118552586 @default.
• W3201546315 hasConceptScore W3201546315C121608353 @default.
• W3201546315 hasConceptScore W3201546315C126322002 @default.
• W3201546315 hasConceptScore W3201546315C126838900 @default.
• W3201546315 hasConceptScore W3201546315C142724271 @default.
• W3201546315 hasConceptScore W3201546315C143409427 @default.
• W3201546315 hasConceptScore W3201546315C160798450 @default.
• W3201546315 hasConceptScore W3201546315C16568411 @default.
• W3201546315 hasConceptScore W3201546315C2775934546 @default.
• W3201546315 hasConceptScore W3201546315C2776235491 @default.
• W3201546315 hasConceptScore W3201546315C2779889316 @default.
• W3201546315 hasConceptScore W3201546315C509974204 @default.

• next