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- W3201549527 endingPage "174507" @default.
- W3201549527 startingPage "174507" @default.
- W3201549527 abstract "Intracerebral hemorrhage (ICH) is a devastating disease, and there is currently no specific pharmacological treatment that can improve clinical outcomes. Y-2 sublingual tablets, each containing 30 mg edaravone and 6 mg (+)-borneol, is undergoing a phase III clinical trial for treatment of ischemic stroke in China. The purpose of the present study is to investigate the efficacy and potential mechanism of Y-2 in a rat model of collagenase IV injection induced ICH. Sublingual administration of Y-2 at the dose of 1, 3 and 6 mg/kg improved ICH-induced sensorimotor dysfunction, alleviated cell death and histopathological change, restored the hippocampal long-term potentiation (LTP), reduced brain edema and maintained blood-brain barrier (BBB) integrality in ICH rats. Further study demonstrated that Y-2 could reduce inflammatory response and oxidative stress by decreasing the levels of myeloperoxidase (MPO), ionized calcium-binding adaptor protein-1 (Iba-1), inflammatory cytokines and oxidative products, inhibit transcription factor nuclear factor-κB (NF-κB) activation, cyclooxygenase-2 (COX-2) and matrix metallopeptidase 9 (MMP-9) expression in brain tissue around in the core regions of hematoma. Importantly, the protective efficacy of Y-2 from ICH-induced injury was superior to edaravone. In conclusion, Y-2 sublingual tablets might be a promising therapeutic agent for the treatment of ICH." @default.
- W3201549527 created "2021-09-27" @default.
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- W3201549527 date "2021-11-01" @default.
- W3201549527 modified "2023-10-03" @default.
- W3201549527 title "Y-2 reduces oxidative stress and inflammation and improves neurological function of collagenase-induced intracerebral hemorrhage rats" @default.
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- W3201549527 cites W1852676216 @default.
- W3201549527 cites W1866876825 @default.
- W3201549527 cites W1968947739 @default.
- W3201549527 cites W1970764391 @default.
- W3201549527 cites W1971156281 @default.
- W3201549527 cites W1975895958 @default.
- W3201549527 cites W1981194197 @default.
- W3201549527 cites W1986639204 @default.
- W3201549527 cites W1987424542 @default.
- W3201549527 cites W1990858068 @default.
- W3201549527 cites W1991660337 @default.
- W3201549527 cites W1991663943 @default.
- W3201549527 cites W1993569783 @default.
- W3201549527 cites W1996003447 @default.
- W3201549527 cites W2001244796 @default.
- W3201549527 cites W2002734542 @default.
- W3201549527 cites W2004872316 @default.
- W3201549527 cites W2016165623 @default.
- W3201549527 cites W2018822649 @default.
- W3201549527 cites W2030529426 @default.
- W3201549527 cites W2034114163 @default.
- W3201549527 cites W2046915310 @default.
- W3201549527 cites W2054058695 @default.
- W3201549527 cites W2058323075 @default.
- W3201549527 cites W2061173173 @default.
- W3201549527 cites W2061415222 @default.
- W3201549527 cites W2079237158 @default.
- W3201549527 cites W2092992935 @default.
- W3201549527 cites W2100167607 @default.
- W3201549527 cites W2101873759 @default.
- W3201549527 cites W2103798426 @default.
- W3201549527 cites W2105196489 @default.
- W3201549527 cites W2117893550 @default.
- W3201549527 cites W2122342801 @default.
- W3201549527 cites W2123301364 @default.
- W3201549527 cites W2132725975 @default.
- W3201549527 cites W2134672868 @default.
- W3201549527 cites W2136587148 @default.
- W3201549527 cites W2137743724 @default.
- W3201549527 cites W2140914384 @default.
- W3201549527 cites W2141258281 @default.
- W3201549527 cites W2142511211 @default.
- W3201549527 cites W2166034362 @default.
- W3201549527 cites W2214900079 @default.
- W3201549527 cites W2290466312 @default.
- W3201549527 cites W2302006867 @default.
- W3201549527 cites W2314947629 @default.
- W3201549527 cites W2334048186 @default.
- W3201549527 cites W2341358513 @default.
- W3201549527 cites W2343783270 @default.
- W3201549527 cites W2396730870 @default.
- W3201549527 cites W2413280690 @default.
- W3201549527 cites W2461626923 @default.
- W3201549527 cites W2469892397 @default.
- W3201549527 cites W2604481254 @default.
- W3201549527 cites W2617729831 @default.
- W3201549527 cites W2768010753 @default.
- W3201549527 cites W2776129125 @default.
- W3201549527 cites W2908850744 @default.
- W3201549527 cites W2920924406 @default.
- W3201549527 cites W2947090542 @default.
- W3201549527 cites W2969287275 @default.
- W3201549527 cites W2987797005 @default.
- W3201549527 cites W3004561611 @default.
- W3201549527 cites W3081130027 @default.
- W3201549527 cites W3129319285 @default.
- W3201549527 cites W328984984 @default.
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- W3201549527 doi "https://doi.org/10.1016/j.ejphar.2021.174507" @default.
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- W3201549527 hasPublicationYear "2021" @default.
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