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• W3201549871 endingPage "153764" @default.
• W3201549871 startingPage "153764" @default.
• W3201549871 abstract "Dehydroevodiamine (DHE), a pivotal quinazoline alkaloid isolated from Fructus Evodiae (Tetradium ruticarpum (A. Juss.) Hartley), has various pharmacological effects. However, the effect of DHE on gastric injury is still uncharted.To clarify the pharmacological effect and mechanism of DHE on gastric injury (GI) induced by indomethacin (IDO).The gastric injury was induced in rat by oral administration of 5 mg/kg IDO for 7 days. Then the rats were treated with DHE (10, 20, 40 mg/kg, ig) for 7 days.The changes of food intake, body weight, gastric pH and general state observation were determined. And HE staining and AB-PAS staining was analyzed. Then, the inflammatory infiltration of gastric tissue was observed through MPO immunohistochemical approach, and the expression of TNF-α, IL-6 and IL-10 were measured. Furthermore, the levels of proteins ERK, p-ERK, P38, p-P38, JNK and p-JNK were determined to elucidate the molecular mechanism of DHE.DHE alleviated food intake reduction, weight loss and gastric injury induced by IDO and made gastric pH and mucosal thickness return to normal. In addition, DHE could down regulate the expression of MPO, TNF-α and IL-6 and up regulate the expression of IL-10 to reduce the damage induced by inflammatory, and create a healing environment. Furthermore, DHE could significantly inhibit the phosphorylation of ERK and p38 not JNK.DHE ameliorated dyspepsia, inflammatory infiltration and tissue damage induced by IDO through ERK and p38 signaling pathways rather than JNK pathway." @default.
• W3201549871 created "2021-09-27" @default.
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• W3201549871 date "2021-12-01" @default.
• W3201549871 modified "2023-10-13" @default.
• W3201549871 title "Dehydroevodiamine ameliorates indomethacin-induced gastric injury via inhibition of ERK and p38 signaling pathway" @default.
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• W3201549871 doi "https://doi.org/10.1016/j.phymed.2021.153764" @default.
• W3201549871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34628242" @default.
• W3201549871 hasPublicationYear "2021" @default.
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