FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201554661> ?p ?o ?g. }

• W3201554661 abstract "Background: Ruminant species are at risk of developing abomasal ulceration, but there is a lack of pharmacokinetic data for anti-ulcer therapies, such as the proton pump inhibitor pantoprazole, in goats. Objective: The primary study objective was to estimate the plasma pharmacokinetic parameters for pantoprazole in adult goats after intravenous administration. A secondary objective was to describe the pharmacokinetic parameters for the metabolite, pantoprazole sulfone, in goats. Methods: Pantoprazole was administered intravenously to six adult goats at a dose of 1 mg/kg. Plasma samples were collected over 36h and analyzed via reverse phase high performance liquid chromatography for determination of pantoprazole and pantoprazole sulfone concentrations. Pharmacokinetic parameters were determined by non-compartmental analysis. Results: Plasma clearance, elimination half-life, and volume of distribution of pantoprazole were estimated at 0.345 mL/kg/min, 0.7 h, and 0.9 L/kg, respectively following IV administration. The maximum concentration, elimination half-life and area under the curve of pantoprazole sulfone were estimated at 0.1 μg/mL, 0.8 h, and 0.2 hr * μg/mL, respectively. The global extraction ratio was estimated 0.00795 ± 0.00138. All animals had normal physical examinations after conclusion of the study. Conclusion: The reported plasma clearance for pantoprazole is lower than reported for foals, calves, and alpacas. The elimination half-life appears to be &lt; that reported for foals and calves. Future pharmacodynamic studies are necessary for determination of the efficacy of pantoprazole on acid suppression in goats." @default.
• W3201554661 created "2021-09-27" @default.
• W3201554661 creator A5009788962 @default.
• W3201554661 creator A5012162460 @default.
• W3201554661 creator A5013069348 @default.
• W3201554661 creator A5021114193 @default.
• W3201554661 creator A5031092581 @default.
• W3201554661 creator A5049357890 @default.
• W3201554661 creator A5065668952 @default.
• W3201554661 creator A5073100370 @default.
• W3201554661 creator A5082728275 @default.
• W3201554661 creator A5083978175 @default.
• W3201554661 date "2021-09-22" @default.
• W3201554661 modified "2023-10-01" @default.
• W3201554661 title "Pharmacokinetics of Pantoprazole and Pantoprazole Sulfone in Goats After Intravenous Administration: A Preliminary Report" @default.
• W3201554661 cites W1512927193 @default.
• W3201554661 cites W1554319537 @default.
• W3201554661 cites W1884477691 @default.
• W3201554661 cites W1963884810 @default.
• W3201554661 cites W1965344429 @default.
• W3201554661 cites W1979482373 @default.
• W3201554661 cites W1980869256 @default.
• W3201554661 cites W1984444505 @default.
• W3201554661 cites W1991896858 @default.
• W3201554661 cites W2007641169 @default.
• W3201554661 cites W2060910714 @default.
• W3201554661 cites W2097478699 @default.
• W3201554661 cites W2102352586 @default.
• W3201554661 cites W2120846424 @default.
• W3201554661 cites W2121292137 @default.
• W3201554661 cites W2224490224 @default.
• W3201554661 cites W2304855287 @default.
• W3201554661 cites W2591884164 @default.
• W3201554661 cites W2599406218 @default.
• W3201554661 cites W2758419511 @default.
• W3201554661 cites W2774512144 @default.
• W3201554661 cites W2780393585 @default.
• W3201554661 cites W2787911919 @default.
• W3201554661 cites W2791677729 @default.
• W3201554661 cites W2794697011 @default.
• W3201554661 cites W2802920809 @default.
• W3201554661 cites W2804965256 @default.
• W3201554661 cites W2886308086 @default.
• W3201554661 cites W2899465300 @default.
• W3201554661 cites W2924302480 @default.
• W3201554661 cites W2978015731 @default.
• W3201554661 cites W2983559488 @default.
• W3201554661 cites W3012187837 @default.
• W3201554661 cites W3028087630 @default.
• W3201554661 cites W3088217708 @default.
• W3201554661 cites W3157438402 @default.
• W3201554661 cites W4231421929 @default.
• W3201554661 cites W2792430003 @default.
• W3201554661 doi "https://doi.org/10.3389/fvets.2021.744813" @default.
• W3201554661 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8492921" @default.
• W3201554661 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34631865" @default.
• W3201554661 hasPublicationYear "2021" @default.
• W3201554661 type Work @default.
• W3201554661 sameAs 3201554661 @default.
• W3201554661 citedByCount "7" @default.
• W3201554661 countsByYear W32015546612022 @default.
• W3201554661 countsByYear W32015546612023 @default.
• W3201554661 crossrefType "journal-article" @default.
• W3201554661 hasAuthorship W3201554661A5009788962 @default.
• W3201554661 hasAuthorship W3201554661A5012162460 @default.
• W3201554661 hasAuthorship W3201554661A5013069348 @default.
• W3201554661 hasAuthorship W3201554661A5021114193 @default.
• W3201554661 hasAuthorship W3201554661A5031092581 @default.
• W3201554661 hasAuthorship W3201554661A5049357890 @default.
• W3201554661 hasAuthorship W3201554661A5065668952 @default.
• W3201554661 hasAuthorship W3201554661A5073100370 @default.
• W3201554661 hasAuthorship W3201554661A5082728275 @default.
• W3201554661 hasAuthorship W3201554661A5083978175 @default.
• W3201554661 hasBestOaLocation W32015546611 @default.
• W3201554661 hasConcept C111113717 @default.
• W3201554661 hasConcept C112705442 @default.
• W3201554661 hasConcept C126322002 @default.
• W3201554661 hasConcept C139254425 @default.
• W3201554661 hasConcept C185592680 @default.
• W3201554661 hasConcept C2777056448 @default.
• W3201554661 hasConcept C2777477808 @default.
• W3201554661 hasConcept C2777498785 @default.
• W3201554661 hasConcept C2781025758 @default.
• W3201554661 hasConcept C2781315423 @default.
• W3201554661 hasConcept C71924100 @default.
• W3201554661 hasConcept C98274493 @default.
• W3201554661 hasConceptScore W3201554661C111113717 @default.
• W3201554661 hasConceptScore W3201554661C112705442 @default.
• W3201554661 hasConceptScore W3201554661C126322002 @default.
• W3201554661 hasConceptScore W3201554661C139254425 @default.
• W3201554661 hasConceptScore W3201554661C185592680 @default.
• W3201554661 hasConceptScore W3201554661C2777056448 @default.
• W3201554661 hasConceptScore W3201554661C2777477808 @default.
• W3201554661 hasConceptScore W3201554661C2777498785 @default.
• W3201554661 hasConceptScore W3201554661C2781025758 @default.
• W3201554661 hasConceptScore W3201554661C2781315423 @default.
• W3201554661 hasConceptScore W3201554661C71924100 @default.
• W3201554661 hasConceptScore W3201554661C98274493 @default.
• W3201554661 hasLocation W32015546611 @default.
• W3201554661 hasLocation W32015546612 @default.

• next