FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201564492> ?p ?o ?g. }

• W3201564492 endingPage "108143" @default.
• W3201564492 startingPage "108143" @default.
• W3201564492 abstract "Glial cell line-derived neurotrophic factor (GDNF) has been reported to protect mice from intestinal inflammation, but its anti-inflammatory mechanisms are poorly understood. Here we found that there was a downregulation in intestinal expression of GDNF accompanied by an increase of M1 macrophages in dextran sulfate sodium (DSS)-induced colitis in mice. GDNF treatment could facilitate the macrophages polarization towards the M2-like phenotype in DSS-treated mice and LPS-stimulated RAW264.7 cells, and reduce pro-inflammatory cytokines and increase anti-inflammatory cytokines. Mechanistically, the activation of PI3K/AKT pathway might contribute to the regulation of GDNF on macrophage phenotypes and inflammatory response. Moreover, the administration of GDNF significantly ameliorated colitis in DSS-treated mice, but this benefit of GDNF was diminished by macrophage depletion. Therefore, we propose a new mechanism whereby GDNF suppresses DSS-induced colitis in mice via a macrophage-mediated pathway." @default.
• W3201564492 created "2021-09-27" @default.
• W3201564492 creator A5084627028 @default.
• W3201564492 creator A5085428821 @default.
• W3201564492 creator A5087780082 @default.
• W3201564492 date "2021-11-01" @default.
• W3201564492 modified "2023-10-07" @default.
• W3201564492 title "Glial cell line-derived neurotrophic factor ameliorates dextran sulfate sodium-induced colitis in mice via a macrophage-mediated pathway" @default.
• W3201564492 cites W1671274164 @default.
• W3201564492 cites W1797422316 @default.
• W3201564492 cites W1907945324 @default.
• W3201564492 cites W1959285104 @default.
• W3201564492 cites W1967369695 @default.
• W3201564492 cites W1969485182 @default.
• W3201564492 cites W1981056356 @default.
• W3201564492 cites W2003882659 @default.
• W3201564492 cites W2008752643 @default.
• W3201564492 cites W2048007675 @default.
• W3201564492 cites W2052721892 @default.
• W3201564492 cites W2057166477 @default.
• W3201564492 cites W2063404685 @default.
• W3201564492 cites W2070855360 @default.
• W3201564492 cites W2078344366 @default.
• W3201564492 cites W2100012692 @default.
• W3201564492 cites W2103747137 @default.
• W3201564492 cites W2120027682 @default.
• W3201564492 cites W2140380746 @default.
• W3201564492 cites W2140472119 @default.
• W3201564492 cites W2176135337 @default.
• W3201564492 cites W2182578492 @default.
• W3201564492 cites W2405925308 @default.
• W3201564492 cites W2528134441 @default.
• W3201564492 cites W2582393724 @default.
• W3201564492 cites W2613367831 @default.
• W3201564492 cites W2620756707 @default.
• W3201564492 cites W2767658071 @default.
• W3201564492 cites W2949183176 @default.
• W3201564492 cites W2950056411 @default.
• W3201564492 cites W2971991233 @default.
• W3201564492 cites W2980787432 @default.
• W3201564492 cites W3006882296 @default.
• W3201564492 cites W3014465352 @default.
• W3201564492 cites W3126863866 @default.
• W3201564492 cites W3131708121 @default.
• W3201564492 doi "https://doi.org/10.1016/j.intimp.2021.108143" @default.
• W3201564492 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34543979" @default.
• W3201564492 hasPublicationYear "2021" @default.
• W3201564492 type Work @default.
• W3201564492 sameAs 3201564492 @default.
• W3201564492 citedByCount "3" @default.
• W3201564492 countsByYear W32015644922022 @default.
• W3201564492 countsByYear W32015644922023 @default.
• W3201564492 crossrefType "journal-article" @default.
• W3201564492 hasAuthorship W3201564492A5084627028 @default.
• W3201564492 hasAuthorship W3201564492A5085428821 @default.
• W3201564492 hasAuthorship W3201564492A5087780082 @default.
• W3201564492 hasConcept C104317684 @default.
• W3201564492 hasConcept C126322002 @default.
• W3201564492 hasConcept C127561419 @default.
• W3201564492 hasConcept C160539049 @default.
• W3201564492 hasConcept C164027704 @default.
• W3201564492 hasConcept C170493617 @default.
• W3201564492 hasConcept C185592680 @default.
• W3201564492 hasConcept C185856081 @default.
• W3201564492 hasConcept C202751555 @default.
• W3201564492 hasConcept C203014093 @default.
• W3201564492 hasConcept C2775862500 @default.
• W3201564492 hasConcept C2776682551 @default.
• W3201564492 hasConcept C2776914184 @default.
• W3201564492 hasConcept C2779244956 @default.
• W3201564492 hasConcept C2779830541 @default.
• W3201564492 hasConcept C502942594 @default.
• W3201564492 hasConcept C55493867 @default.
• W3201564492 hasConcept C62478195 @default.
• W3201564492 hasConcept C71924100 @default.
• W3201564492 hasConcept C75217442 @default.
• W3201564492 hasConcept C86554907 @default.
• W3201564492 hasConcept C86803240 @default.
• W3201564492 hasConcept C95444343 @default.
• W3201564492 hasConcept C98274493 @default.
• W3201564492 hasConceptScore W3201564492C104317684 @default.
• W3201564492 hasConceptScore W3201564492C126322002 @default.
• W3201564492 hasConceptScore W3201564492C127561419 @default.
• W3201564492 hasConceptScore W3201564492C160539049 @default.
• W3201564492 hasConceptScore W3201564492C164027704 @default.
• W3201564492 hasConceptScore W3201564492C170493617 @default.
• W3201564492 hasConceptScore W3201564492C185592680 @default.
• W3201564492 hasConceptScore W3201564492C185856081 @default.
• W3201564492 hasConceptScore W3201564492C202751555 @default.
• W3201564492 hasConceptScore W3201564492C203014093 @default.
• W3201564492 hasConceptScore W3201564492C2775862500 @default.
• W3201564492 hasConceptScore W3201564492C2776682551 @default.
• W3201564492 hasConceptScore W3201564492C2776914184 @default.
• W3201564492 hasConceptScore W3201564492C2779244956 @default.
• W3201564492 hasConceptScore W3201564492C2779830541 @default.
• W3201564492 hasConceptScore W3201564492C502942594 @default.
• W3201564492 hasConceptScore W3201564492C55493867 @default.
• W3201564492 hasConceptScore W3201564492C62478195 @default.

• next