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- W3201573108 abstract "In neurons, mitochondria are transported to distal regions for supplying energy and buffer calcium. Mitochondrial transport is mediated by Miro and TRAK adaptors that recruit kinesin and dynein-dynactin. To understand how mitochondria are transported by these opposing motors and stalled at regions with elevated calcium levels, we reconstituted the mitochondrial transport machinery in vitro. We show that the coiled-coil domain of TRAK activates dynein-dynactin motility, but kinesin requires an additional factor to efficiently transport Miro/TRAK. Unexpectedly, TRAK adaptors that recruit both motors move towards the plus-end, whereas kinesin is excluded from binding TRAK transported by dynein-dynactin. The assembly and motility of the transport machinery are not affected by calcium. Instead, the mitochondrial docking protein syntaphilin is sufficient to oppose the forces generated by kinesin and stall the motility. Our results provide mechanistic insight into how mitochondria are transported by the coordinated action of motors and statically anchored to regions with high neuronal activity." @default.
- W3201573108 created "2021-09-27" @default.
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- W3201573108 date "2021-07-31" @default.
- W3201573108 modified "2023-09-23" @default.
- W3201573108 title "Mitochondrial TRAK adaptors coordinate dynein and kinesin motility" @default.
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