FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201600996> ?p ?o ?g. }

• W3201600996 abstract "Ultrasound contrast agents (UCA) are comprised of microbubbles stabilized by a shell. The benefits of ultrasound (US) to parenteral drug delivery are well documented. In conjunction with US-induced cavitation of co-administered UCA they include an increase in drug efficacy due to increases in both vascular gap junctions and cellular membrane permeabilities. We have developed a drug-loaded UCA which upon reaching the desired site (generally a solid tumor) ruptures under the influence of the focused US. UCA cavitation, combined with acoustic radiation forces, and the enhanced permeation and retention effect (EPR) are expected to increase tumor uptake of the produced fragments, providing a sustained, intratumoralrelease of any associated drug.In this thesis, poly (lactic acid) (PLA) UCA have been developed for drug delivery utilizing doxorubicin (Dox). These agents provide 15-20 dB of US contrast enhancement both in vitro and in vivo. The agents have been optimized to encapsulate Dox while maintaining a high sensitivity to US. Prior to sonication these agents have a mean diameter of 1.4-1.8 μm, restricting them to the vasculature until rupture. In vitro data indicate particles reach sizes of 200-400 nm after sonication. Electron microscopy of ruptured particles depicts both fragmentation and shriveling of shells, resulting in sub-micron, drug loaded particles.In vitro these agents become significantly more potent to the human breast cancer cell line MDA-MB-231 after sonication, nearly doubling the degree of cell death compared to non-insonated controls (p=0.0272). Microscopy shows that Dox from the fragments is transported to the cell nucleus once within the cell. Additionally, during US triggered generation, Dox eluting species can be forced through a 0.4 μm membrane. These data demonstrate potential for a PLA-Dox UCA platform to deliver Dox eluting nanoparticles to the tumor interstitium. Elution profiles have been measured, indicating that 76% of drug payload is released over a 24 day period.Studies using VX2 tumors in rabbits show the activated platform is detectable within tumor vasculature and results in substantial increases in intratumoral drug levels with greater than a 100% increase in delivery efficiency compared to the noninsonated platform (p=0.004)%%%%Ph.D., Biomedical Engineering  – Drexel University, 2010" @default.
• W3201600996 created "2021-09-27" @default.
• W3201600996 creator A5067330326 @default.
• W3201600996 date "2021-07-16" @default.
• W3201600996 modified "2023-09-27" @default.
• W3201600996 title "Ultrasound sensitive polymeric drug carriers for treatment of solid tumors" @default.
• W3201600996 cites W1930683464 @default.
• W3201600996 cites W1964071243 @default.
• W3201600996 cites W1965458400 @default.
• W3201600996 cites W1968098211 @default.
• W3201600996 cites W1968526144 @default.
• W3201600996 cites W1969238509 @default.
• W3201600996 cites W1969793936 @default.
• W3201600996 cites W1971499045 @default.
• W3201600996 cites W1971996152 @default.
• W3201600996 cites W1973391358 @default.
• W3201600996 cites W1974895955 @default.
• W3201600996 cites W1975340808 @default.
• W3201600996 cites W1979319140 @default.
• W3201600996 cites W1981907528 @default.
• W3201600996 cites W1984001852 @default.
• W3201600996 cites W1985858988 @default.
• W3201600996 cites W1987593270 @default.
• W3201600996 cites W1987681502 @default.
• W3201600996 cites W1990073288 @default.
• W3201600996 cites W1990505272 @default.
• W3201600996 cites W1991146807 @default.
• W3201600996 cites W1993845520 @default.
• W3201600996 cites W1995873025 @default.
• W3201600996 cites W1997541716 @default.
• W3201600996 cites W1998476547 @default.
• W3201600996 cites W2000404504 @default.
• W3201600996 cites W2000573877 @default.
• W3201600996 cites W2002516695 @default.
• W3201600996 cites W2007292189 @default.
• W3201600996 cites W2007457253 @default.
• W3201600996 cites W2009707583 @default.
• W3201600996 cites W2011945218 @default.
• W3201600996 cites W2013844718 @default.
• W3201600996 cites W2020267062 @default.
• W3201600996 cites W2020670695 @default.
• W3201600996 cites W2024272656 @default.
• W3201600996 cites W2025153805 @default.
• W3201600996 cites W2027410903 @default.
• W3201600996 cites W2028494178 @default.
• W3201600996 cites W2031338851 @default.
• W3201600996 cites W2031846187 @default.
• W3201600996 cites W2032760352 @default.
• W3201600996 cites W2033699650 @default.
• W3201600996 cites W2034051916 @default.
• W3201600996 cites W2036015275 @default.
• W3201600996 cites W2036203675 @default.
• W3201600996 cites W2038753313 @default.
• W3201600996 cites W2038894713 @default.
• W3201600996 cites W2040770723 @default.
• W3201600996 cites W2041038761 @default.
• W3201600996 cites W2041610099 @default.
• W3201600996 cites W2051601156 @default.
• W3201600996 cites W2056090551 @default.
• W3201600996 cites W2062063474 @default.
• W3201600996 cites W2065741172 @default.
• W3201600996 cites W2068517324 @default.
• W3201600996 cites W2068567523 @default.
• W3201600996 cites W2068793664 @default.
• W3201600996 cites W2069569961 @default.
• W3201600996 cites W2070151367 @default.
• W3201600996 cites W2070492091 @default.
• W3201600996 cites W2070668050 @default.
• W3201600996 cites W2071282740 @default.
• W3201600996 cites W2071536867 @default.
• W3201600996 cites W2071858016 @default.
• W3201600996 cites W2074989418 @default.
• W3201600996 cites W2077772226 @default.
• W3201600996 cites W2078027484 @default.
• W3201600996 cites W2078243247 @default.
• W3201600996 cites W2079104743 @default.
• W3201600996 cites W2079933267 @default.
• W3201600996 cites W2081938664 @default.
• W3201600996 cites W2083437069 @default.
• W3201600996 cites W2086088354 @default.
• W3201600996 cites W2088581865 @default.
• W3201600996 cites W2089553479 @default.
• W3201600996 cites W2090541867 @default.
• W3201600996 cites W2091056728 @default.
• W3201600996 cites W2092373300 @default.
• W3201600996 cites W2094237675 @default.
• W3201600996 cites W2097583559 @default.
• W3201600996 cites W2105029697 @default.
• W3201600996 cites W2105173193 @default.
• W3201600996 cites W2106787323 @default.
• W3201600996 cites W2109133888 @default.
• W3201600996 cites W2110330006 @default.
• W3201600996 cites W2111543696 @default.
• W3201600996 cites W2115228176 @default.
• W3201600996 cites W2116162163 @default.
• W3201600996 cites W2128772718 @default.
• W3201600996 cites W2131520309 @default.
• W3201600996 cites W2133862169 @default.
• W3201600996 cites W2137493748 @default.
• W3201600996 cites W2141394481 @default.

• next