FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201601156> ?p ?o ?g. }

• W3201601156 endingPage "1679" @default.
• W3201601156 startingPage "1666" @default.
• W3201601156 abstract "Mesenchymal stromal cells (MSCs) from both humans and horses, which represent a clinically relevant translation animal model for human cutaneous wound healing, were recently found to possess antimicrobial properties against planktonic bacteria, and in the case of equine MSCs, also against biofilms. This, together with previous findings that human and equine MSCs promote angiogenesis and wound healing, makes these cells an attractive approach to treat infected cutaneous wounds in both species. The anti-biofilm activities of equine MSC, via secretion of cysteine proteases, have only been demonstrated in vitro, thus lacking information about in vivo relevance. Moreover, the effects of the equine MSC secretome on resident skin cells have not yet been explored. The goals of this study were to (a) test the efficacy of the MSC secretome in a physiologically relevant ex vivo equine skin biofilm explant model and (b) explore the impact of the MSC secretome on the antimicrobial defense mechanisms of resident skin cells. Our salient findings were that secreted factors from equine MSCs significantly decreased viability of methicillin-resistant Staphylococcus aureus bacteria in mature biofilms in this novel skin biofilm explant model. Moreover, we demonstrated that equine MSCs secrete CCL2 that increases the antimicrobial activity of equine keratinocytes by stimulating expression of antimicrobial peptides. Collectively, these data contribute to our understanding of the MSC secretome's antimicrobial properties, both directly by killing bacteria and indirectly by stimulating immune responses of surrounding resident skin cells, thus further supporting the value of MSC secretome-based treatments for infected wounds." @default.
• W3201601156 created "2021-09-27" @default.
• W3201601156 creator A5012759807 @default.
• W3201601156 creator A5046393917 @default.
• W3201601156 creator A5055193840 @default.
• W3201601156 creator A5057290159 @default.
• W3201601156 creator A5074374287 @default.
• W3201601156 date "2021-09-16" @default.
• W3201601156 modified "2023-10-15" @default.
• W3201601156 title "Mesenchymal Stromal Cell-Secreted CCL2 Promotes Antibacterial Defense Mechanisms Through Increased Antimicrobial Peptide Expression in Keratinocytes" @default.
• W3201601156 cites W1493141693 @default.
• W3201601156 cites W1527957830 @default.
• W3201601156 cites W1528623386 @default.
• W3201601156 cites W1529075884 @default.
• W3201601156 cites W1563852071 @default.
• W3201601156 cites W1746246068 @default.
• W3201601156 cites W1847701810 @default.
• W3201601156 cites W1918535864 @default.
• W3201601156 cites W1971255678 @default.
• W3201601156 cites W1989945338 @default.
• W3201601156 cites W1992034405 @default.
• W3201601156 cites W2003623305 @default.
• W3201601156 cites W2007121925 @default.
• W3201601156 cites W2009528971 @default.
• W3201601156 cites W2011780975 @default.
• W3201601156 cites W2020587065 @default.
• W3201601156 cites W2032329609 @default.
• W3201601156 cites W2034047115 @default.
• W3201601156 cites W2036011337 @default.
• W3201601156 cites W2036596008 @default.
• W3201601156 cites W2040227387 @default.
• W3201601156 cites W2043264497 @default.
• W3201601156 cites W2046208657 @default.
• W3201601156 cites W2056064788 @default.
• W3201601156 cites W2077288743 @default.
• W3201601156 cites W2077590888 @default.
• W3201601156 cites W2079366299 @default.
• W3201601156 cites W2085436481 @default.
• W3201601156 cites W2093412162 @default.
• W3201601156 cites W2094024512 @default.
• W3201601156 cites W2094036101 @default.
• W3201601156 cites W2099112674 @default.
• W3201601156 cites W2112758751 @default.
• W3201601156 cites W2114290482 @default.
• W3201601156 cites W2115622227 @default.
• W3201601156 cites W2117220410 @default.
• W3201601156 cites W2122746082 @default.
• W3201601156 cites W2124396531 @default.
• W3201601156 cites W2139601739 @default.
• W3201601156 cites W2143864863 @default.
• W3201601156 cites W2167056542 @default.
• W3201601156 cites W2168904145 @default.
• W3201601156 cites W2171414599 @default.
• W3201601156 cites W2519890047 @default.
• W3201601156 cites W2564802265 @default.
• W3201601156 cites W2567221680 @default.
• W3201601156 cites W2593364664 @default.
• W3201601156 cites W2604586179 @default.
• W3201601156 cites W2621879589 @default.
• W3201601156 cites W2732839963 @default.
• W3201601156 cites W2738844374 @default.
• W3201601156 cites W2783373728 @default.
• W3201601156 cites W2794393811 @default.
• W3201601156 cites W2808158796 @default.
• W3201601156 cites W2810850614 @default.
• W3201601156 cites W2887057531 @default.
• W3201601156 cites W2889964553 @default.
• W3201601156 cites W2892654432 @default.
• W3201601156 cites W2896863951 @default.
• W3201601156 cites W2897553060 @default.
• W3201601156 cites W2922835591 @default.
• W3201601156 cites W2940897784 @default.
• W3201601156 cites W2968815091 @default.
• W3201601156 cites W2980691057 @default.
• W3201601156 cites W3013540420 @default.
• W3201601156 cites W3108814596 @default.
• W3201601156 cites W3190337811 @default.
• W3201601156 cites W3201601156 @default.
• W3201601156 doi "https://doi.org/10.1002/sctm.21-0058" @default.
• W3201601156 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34528765" @default.
• W3201601156 hasPublicationYear "2021" @default.
• W3201601156 type Work @default.
• W3201601156 sameAs 3201601156 @default.
• W3201601156 citedByCount "20" @default.
• W3201601156 countsByYear W32016011562021 @default.
• W3201601156 countsByYear W32016011562022 @default.
• W3201601156 countsByYear W32016011562023 @default.
• W3201601156 crossrefType "journal-article" @default.
• W3201601156 hasAuthorship W3201601156A5012759807 @default.
• W3201601156 hasAuthorship W3201601156A5046393917 @default.
• W3201601156 hasAuthorship W3201601156A5055193840 @default.
• W3201601156 hasAuthorship W3201601156A5057290159 @default.
• W3201601156 hasAuthorship W3201601156A5074374287 @default.
• W3201601156 hasBestOaLocation W32016011561 @default.
• W3201601156 hasConcept C150903083 @default.
• W3201601156 hasConcept C16930146 @default.
• W3201601156 hasConcept C198826908 @default.
• W3201601156 hasConcept C203014093 @default.

• next