FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201602764> ?p ?o ?g. }

• W3201602764 endingPage "2947" @default.
• W3201602764 startingPage "2932" @default.
• W3201602764 abstract "Mitochondria-associated ER membranes (MAMs) are formed by close and specific components in the contact sites between the endoplasmic reticulum (ER) and mitochondria, which participate in several cell functions, including lipid metabolism, autophagy, and Ca2+ signaling. Particularly, the presence of α-synuclein (α-syn) in MAMs was previously demonstrated, indicating a physical interaction among some proteins in this region and a potential involvement in cell dysfunctions. MAMs alterations are associated with neurodegenerative diseases such as Parkinson's disease (PD) and contribute to the pathogenesis features. Here, we investigated the effects of α-syn on MAMs and Ca2+ transfer from the ER to mitochondria in WT- and A30P α-syn-overexpressing SH-SY5Y or HEK293 cells. We observed that α-syn potentiates the mitochondrial membrane potential (Δψm) loss induced by rotenone, increases mitophagy and mitochondrial Ca2+ overload. Additionally, in α-syn-overexpressing cells, we found a reduction in ER–mitochondria contact sites through the impairment of the GRP75–IP3R interaction, however, with no alteration in VDAC1–GRP75 interaction. Consequently, after Ca2+ release from the ER, α-syn-overexpressing cells demonstrated a reduction in Ca2+ buffering by mitochondria, suggesting a deregulation in MAM activity. Taken together, our data highlight the importance of the α-syn/MAMs/Ca2+ axis that potentially affects cell functions in PD." @default.
• W3201602764 created "2021-09-27" @default.
• W3201602764 creator A5001000307 @default.
• W3201602764 creator A5012752338 @default.
• W3201602764 creator A5023900503 @default.
• W3201602764 creator A5036125335 @default.
• W3201602764 creator A5043261491 @default.
• W3201602764 creator A5050710377 @default.
• W3201602764 creator A5054119713 @default.
• W3201602764 date "2021-09-12" @default.
• W3201602764 modified "2023-10-02" @default.
• W3201602764 title "Overexpression of α‐synuclein inhibits mitochondrial Ca ²⁺ trafficking between the endoplasmic reticulum and mitochondria through MAMs by altering the GRP75–IP3R interaction" @default.
• W3201602764 cites W1527671059 @default.
• W3201602764 cites W1852530796 @default.
• W3201602764 cites W1997101343 @default.
• W3201602764 cites W2032770343 @default.
• W3201602764 cites W2049612563 @default.
• W3201602764 cites W2050786534 @default.
• W3201602764 cites W2054490148 @default.
• W3201602764 cites W2055308573 @default.
• W3201602764 cites W2062061647 @default.
• W3201602764 cites W2066088939 @default.
• W3201602764 cites W2068288454 @default.
• W3201602764 cites W2074833985 @default.
• W3201602764 cites W2082315075 @default.
• W3201602764 cites W2083243127 @default.
• W3201602764 cites W2091265794 @default.
• W3201602764 cites W2094999489 @default.
• W3201602764 cites W2096579721 @default.
• W3201602764 cites W2108326484 @default.
• W3201602764 cites W2129146981 @default.
• W3201602764 cites W2131522485 @default.
• W3201602764 cites W2135466257 @default.
• W3201602764 cites W2150656456 @default.
• W3201602764 cites W2155015733 @default.
• W3201602764 cites W2157535220 @default.
• W3201602764 cites W2162660025 @default.
• W3201602764 cites W2166131107 @default.
• W3201602764 cites W2172066700 @default.
• W3201602764 cites W2279311208 @default.
• W3201602764 cites W2312602181 @default.
• W3201602764 cites W2568957872 @default.
• W3201602764 cites W2580573179 @default.
• W3201602764 cites W2587082207 @default.
• W3201602764 cites W2599239219 @default.
• W3201602764 cites W2620745816 @default.
• W3201602764 cites W2771563832 @default.
• W3201602764 cites W2794137713 @default.
• W3201602764 cites W2795236460 @default.
• W3201602764 cites W2796389302 @default.
• W3201602764 cites W2799765287 @default.
• W3201602764 cites W2807663565 @default.
• W3201602764 cites W2892332054 @default.
• W3201602764 cites W2921947689 @default.
• W3201602764 cites W2983911660 @default.
• W3201602764 cites W2986329263 @default.
• W3201602764 cites W2990547772 @default.
• W3201602764 cites W3002202489 @default.
• W3201602764 doi "https://doi.org/10.1002/jnr.24952" @default.
• W3201602764 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34510532" @default.
• W3201602764 hasPublicationYear "2021" @default.
• W3201602764 type Work @default.
• W3201602764 sameAs 3201602764 @default.
• W3201602764 citedByCount "22" @default.
• W3201602764 countsByYear W32016027642022 @default.
• W3201602764 countsByYear W32016027642023 @default.
• W3201602764 crossrefType "journal-article" @default.
• W3201602764 hasAuthorship W3201602764A5001000307 @default.
• W3201602764 hasAuthorship W3201602764A5012752338 @default.
• W3201602764 hasAuthorship W3201602764A5023900503 @default.
• W3201602764 hasAuthorship W3201602764A5036125335 @default.
• W3201602764 hasAuthorship W3201602764A5043261491 @default.
• W3201602764 hasAuthorship W3201602764A5050710377 @default.
• W3201602764 hasAuthorship W3201602764A5054119713 @default.
• W3201602764 hasConcept C104317684 @default.
• W3201602764 hasConcept C146587185 @default.
• W3201602764 hasConcept C1491633281 @default.
• W3201602764 hasConcept C158617107 @default.
• W3201602764 hasConcept C181199279 @default.
• W3201602764 hasConcept C185592680 @default.
• W3201602764 hasConcept C190283241 @default.
• W3201602764 hasConcept C203522944 @default.
• W3201602764 hasConcept C2779058106 @default.
• W3201602764 hasConcept C2779324830 @default.
• W3201602764 hasConcept C28859421 @default.
• W3201602764 hasConcept C547475151 @default.
• W3201602764 hasConcept C55493867 @default.
• W3201602764 hasConcept C86803240 @default.
• W3201602764 hasConcept C95444343 @default.
• W3201602764 hasConcept C98539663 @default.
• W3201602764 hasConceptScore W3201602764C104317684 @default.
• W3201602764 hasConceptScore W3201602764C146587185 @default.
• W3201602764 hasConceptScore W3201602764C1491633281 @default.
• W3201602764 hasConceptScore W3201602764C158617107 @default.
• W3201602764 hasConceptScore W3201602764C181199279 @default.
• W3201602764 hasConceptScore W3201602764C185592680 @default.
• W3201602764 hasConceptScore W3201602764C190283241 @default.
• W3201602764 hasConceptScore W3201602764C203522944 @default.

• next