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• W3201607434 endingPage "4394" @default.
• W3201607434 startingPage "4383" @default.
• W3201607434 abstract "Typical glucose oxidase (GOx)-based starvation therapy is a promising strategy for tumor treatment; however, it is still difficult to achieve an effective therapeutic effect via a single starvation therapy. Herein, we designed a pH-sensitive polymeric vesicle (PV) self-assembled by histamine-modified chondroitin sulfate (CS-his) for codelivery of GOx and l-buthionine sulfoximine (BSO). GOx can consume glucose to induce the starvation therapy after the PVs reach cancer cell. Moreover, the product H2O2 will be reduced by a high concentration of glutathione (GSH) in the tumor cell, resulting in a reduction of the GSH content. The released BSO finally further reduced the GSH level. As a result, the signaling pathway of the ferroptosis will be activated. The in vivo results demonstrated that GOx/BSO@CS PVs exhibit a good inhibitory effect on the growth of 4T1 tumors in mice. Thus, this work provides a facile strategy to prepare pH-sensitive nanomedicine for synergistic starvation-ferroptosis therapy of tumor." @default.
• W3201607434 created "2021-09-27" @default.
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• W3201607434 date "2021-09-17" @default.
• W3201607434 modified "2023-10-16" @default.
• W3201607434 title "pH-Sensitive Polymeric Vesicles for GOx/BSO Delivery and Synergetic Starvation-Ferroptosis Therapy of Tumor" @default.
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• W3201607434 doi "https://doi.org/10.1021/acs.biomac.1c00960" @default.
• W3201607434 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34533297" @default.
• W3201607434 hasPublicationYear "2021" @default.
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