FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201609228> ?p ?o ?g. }

• W3201609228 endingPage "9764" @default.
• W3201609228 startingPage "9764" @default.
• W3201609228 abstract "Heterogeneous nuclear ribonucleoprotein K (hnRNPK) is an RNA/DNA binding protein involved in diverse cell processes; it is also a p53 coregulator that initiates apoptosis under DNA damage conditions. However, the upregulation of hnRNPK is correlated with cancer transformation, progression, and migration, whereas the regulatory role of hnRNPK in cancer malignancy remains unclear. We previously showed that arginine methylation of hnRNPK attenuated the apoptosis of U2OS osteosarcoma cells under DNA damage conditions, whereas the replacement of endogenous hnRNPK with a methylation-defective mutant inversely enhanced apoptosis. The present study further revealed that an RNA helicase, DDX3, whose C-terminus preferentially binds to the unmethylated hnRNPK and could promote such apoptotic enhancement. Moreover, C-terminus-truncated DDX3 induced significantly less apoptosis than full-length DDX3. Notably, we also identified a small molecule that docks at the ATP-binding site of DDX3, promotes the DDX3-hnRNPK interaction, and induces further apoptosis. Overall, we have shown that the arginine methylation of hnRNPK suppresses the apoptosis of U2OS cells via interfering with DDX3-hnRNPK interaction. On the other hand, DDX3-hnRNPK interaction with a proapoptotic role may serve as a target for promoting apoptosis in osteosarcoma cells." @default.
• W3201609228 created "2021-09-27" @default.
• W3201609228 creator A5011978623 @default.
• W3201609228 creator A5025108108 @default.
• W3201609228 creator A5043985731 @default.
• W3201609228 creator A5073923353 @default.
• W3201609228 creator A5077205752 @default.
• W3201609228 date "2021-09-09" @default.
• W3201609228 modified "2023-09-29" @default.
• W3201609228 title "Arginine Methylation of hnRNPK Inhibits the DDX3-hnRNPK Interaction to Play an Anti-Apoptosis Role in Osteosarcoma Cells" @default.
• W3201609228 cites W146972387 @default.
• W3201609228 cites W1903147643 @default.
• W3201609228 cites W1958860233 @default.
• W3201609228 cites W1970894748 @default.
• W3201609228 cites W1976865161 @default.
• W3201609228 cites W1977391239 @default.
• W3201609228 cites W1981014040 @default.
• W3201609228 cites W1993720756 @default.
• W3201609228 cites W1993844923 @default.
• W3201609228 cites W1994341974 @default.
• W3201609228 cites W2003748625 @default.
• W3201609228 cites W2006664760 @default.
• W3201609228 cites W2011878209 @default.
• W3201609228 cites W2012729110 @default.
• W3201609228 cites W2028342121 @default.
• W3201609228 cites W2031165233 @default.
• W3201609228 cites W2039885485 @default.
• W3201609228 cites W2065118037 @default.
• W3201609228 cites W2065740422 @default.
• W3201609228 cites W2071198627 @default.
• W3201609228 cites W2071591548 @default.
• W3201609228 cites W2082948772 @default.
• W3201609228 cites W2090930987 @default.
• W3201609228 cites W2097187394 @default.
• W3201609228 cites W2100973298 @default.
• W3201609228 cites W2106854623 @default.
• W3201609228 cites W2130873468 @default.
• W3201609228 cites W2135805396 @default.
• W3201609228 cites W2137840425 @default.
• W3201609228 cites W2150840879 @default.
• W3201609228 cites W2161939453 @default.
• W3201609228 cites W2168374849 @default.
• W3201609228 cites W2171021773 @default.
• W3201609228 cites W2187758136 @default.
• W3201609228 cites W2194336817 @default.
• W3201609228 cites W2255275506 @default.
• W3201609228 cites W2267877576 @default.
• W3201609228 cites W2325102303 @default.
• W3201609228 cites W2376006428 @default.
• W3201609228 cites W2409993632 @default.
• W3201609228 cites W2511587957 @default.
• W3201609228 cites W2520591314 @default.
• W3201609228 cites W2800897838 @default.
• W3201609228 cites W2925962327 @default.
• W3201609228 cites W2936935677 @default.
• W3201609228 cites W2944131629 @default.
• W3201609228 cites W2945298875 @default.
• W3201609228 cites W2961707593 @default.
• W3201609228 cites W2966422838 @default.
• W3201609228 cites W2974168146 @default.
• W3201609228 doi "https://doi.org/10.3390/ijms22189764" @default.
• W3201609228 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8469703" @default.
• W3201609228 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34575922" @default.
• W3201609228 hasPublicationYear "2021" @default.
• W3201609228 type Work @default.
• W3201609228 sameAs 3201609228 @default.
• W3201609228 citedByCount "6" @default.
• W3201609228 countsByYear W32016092282022 @default.
• W3201609228 countsByYear W32016092282023 @default.
• W3201609228 crossrefType "journal-article" @default.
• W3201609228 hasAuthorship W3201609228A5011978623 @default.
• W3201609228 hasAuthorship W3201609228A5025108108 @default.
• W3201609228 hasAuthorship W3201609228A5043985731 @default.
• W3201609228 hasAuthorship W3201609228A5073923353 @default.
• W3201609228 hasAuthorship W3201609228A5077205752 @default.
• W3201609228 hasBestOaLocation W32016092281 @default.
• W3201609228 hasConcept C104317684 @default.
• W3201609228 hasConcept C127561419 @default.
• W3201609228 hasConcept C150194340 @default.
• W3201609228 hasConcept C185592680 @default.
• W3201609228 hasConcept C190283241 @default.
• W3201609228 hasConcept C190727270 @default.
• W3201609228 hasConcept C2777468819 @default.
• W3201609228 hasConcept C33288867 @default.
• W3201609228 hasConcept C502942594 @default.
• W3201609228 hasConcept C515207424 @default.
• W3201609228 hasConcept C552990157 @default.
• W3201609228 hasConcept C55493867 @default.
• W3201609228 hasConcept C86803240 @default.
• W3201609228 hasConcept C95444343 @default.
• W3201609228 hasConceptScore W3201609228C104317684 @default.
• W3201609228 hasConceptScore W3201609228C127561419 @default.
• W3201609228 hasConceptScore W3201609228C150194340 @default.
• W3201609228 hasConceptScore W3201609228C185592680 @default.
• W3201609228 hasConceptScore W3201609228C190283241 @default.
• W3201609228 hasConceptScore W3201609228C190727270 @default.
• W3201609228 hasConceptScore W3201609228C2777468819 @default.
• W3201609228 hasConceptScore W3201609228C33288867 @default.

• next