Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201610942> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W3201610942 abstract "Abstract Background Astragali Radix (AR),the dried root of legumes, belongs to the Qi- invigorating herbs in traditional Chinese medicine and plays an important role in the treatment of many diseases. In order to understand the mechanism of action of AR extract, we used AR extract to treat M-1, mouse kidney cells, and used transcriptome sequencing technology to detect the genomic transcription level of the cells under the action of AR at different concentrations and times. Result The results showed that after a low concentration of AR treatments on the cells, the expression of genes related to cell growth and cellular immune response changed significantly, among which multiple genes are related to mitochondrial function, while high concentrations of AR affected the expression of histones and disease-related genes. It showed that the low concentration of AR extract can achieve the effect of invigorating Qi by regulating the function of mitochondria. In addition, several important genes and pathways were identified as potential targets of AR activation. Conclusion The research not only clarified the main molecular biological mechanism of AR invigorating Qi, but also provided experimental basis and cellular physiology reference for the further clinical application of AR." @default.
- W3201610942 created "2021-09-27" @default.
- W3201610942 creator A5001434487 @default.
- W3201610942 creator A5010289544 @default.
- W3201610942 creator A5032065022 @default.
- W3201610942 creator A5032182884 @default.
- W3201610942 creator A5041764652 @default.
- W3201610942 creator A5050354209 @default.
- W3201610942 creator A5052676364 @default.
- W3201610942 creator A5057899933 @default.
- W3201610942 creator A5067985339 @default.
- W3201610942 creator A5085264222 @default.
- W3201610942 creator A5086819279 @default.
- W3201610942 date "2021-09-15" @default.
- W3201610942 modified "2023-10-03" @default.
- W3201610942 title "Transcriptome Analysis of gene in Mouse M-1 cells revealing the functional mechanism of Astragali radix extract" @default.
- W3201610942 doi "https://doi.org/10.21203/rs.3.rs-889398/v1" @default.
- W3201610942 hasPublicationYear "2021" @default.
- W3201610942 type Work @default.
- W3201610942 sameAs 3201610942 @default.
- W3201610942 citedByCount "0" @default.
- W3201610942 crossrefType "posted-content" @default.
- W3201610942 hasAuthorship W3201610942A5001434487 @default.
- W3201610942 hasAuthorship W3201610942A5010289544 @default.
- W3201610942 hasAuthorship W3201610942A5032065022 @default.
- W3201610942 hasAuthorship W3201610942A5032182884 @default.
- W3201610942 hasAuthorship W3201610942A5041764652 @default.
- W3201610942 hasAuthorship W3201610942A5050354209 @default.
- W3201610942 hasAuthorship W3201610942A5052676364 @default.
- W3201610942 hasAuthorship W3201610942A5057899933 @default.
- W3201610942 hasAuthorship W3201610942A5067985339 @default.
- W3201610942 hasAuthorship W3201610942A5085264222 @default.
- W3201610942 hasAuthorship W3201610942A5086819279 @default.
- W3201610942 hasBestOaLocation W32016109421 @default.
- W3201610942 hasConcept C104317684 @default.
- W3201610942 hasConcept C14036430 @default.
- W3201610942 hasConcept C142724271 @default.
- W3201610942 hasConcept C150194340 @default.
- W3201610942 hasConcept C162317418 @default.
- W3201610942 hasConcept C188947578 @default.
- W3201610942 hasConcept C202751555 @default.
- W3201610942 hasConcept C204787440 @default.
- W3201610942 hasConcept C2776120743 @default.
- W3201610942 hasConcept C2779091547 @default.
- W3201610942 hasConcept C54355233 @default.
- W3201610942 hasConcept C556039675 @default.
- W3201610942 hasConcept C59822182 @default.
- W3201610942 hasConcept C71924100 @default.
- W3201610942 hasConcept C86803240 @default.
- W3201610942 hasConcept C8891405 @default.
- W3201610942 hasConcept C95444343 @default.
- W3201610942 hasConcept C98274493 @default.
- W3201610942 hasConceptScore W3201610942C104317684 @default.
- W3201610942 hasConceptScore W3201610942C14036430 @default.
- W3201610942 hasConceptScore W3201610942C142724271 @default.
- W3201610942 hasConceptScore W3201610942C150194340 @default.
- W3201610942 hasConceptScore W3201610942C162317418 @default.
- W3201610942 hasConceptScore W3201610942C188947578 @default.
- W3201610942 hasConceptScore W3201610942C202751555 @default.
- W3201610942 hasConceptScore W3201610942C204787440 @default.
- W3201610942 hasConceptScore W3201610942C2776120743 @default.
- W3201610942 hasConceptScore W3201610942C2779091547 @default.
- W3201610942 hasConceptScore W3201610942C54355233 @default.
- W3201610942 hasConceptScore W3201610942C556039675 @default.
- W3201610942 hasConceptScore W3201610942C59822182 @default.
- W3201610942 hasConceptScore W3201610942C71924100 @default.
- W3201610942 hasConceptScore W3201610942C86803240 @default.
- W3201610942 hasConceptScore W3201610942C8891405 @default.
- W3201610942 hasConceptScore W3201610942C95444343 @default.
- W3201610942 hasConceptScore W3201610942C98274493 @default.
- W3201610942 hasLocation W32016109421 @default.
- W3201610942 hasLocation W32016109422 @default.
- W3201610942 hasOpenAccess W3201610942 @default.
- W3201610942 hasPrimaryLocation W32016109421 @default.
- W3201610942 hasRelatedWork W2009966535 @default.
- W3201610942 hasRelatedWork W2102579905 @default.
- W3201610942 hasRelatedWork W2350316464 @default.
- W3201610942 hasRelatedWork W2352209557 @default.
- W3201610942 hasRelatedWork W2358252278 @default.
- W3201610942 hasRelatedWork W2380872913 @default.
- W3201610942 hasRelatedWork W2381669424 @default.
- W3201610942 hasRelatedWork W2412575660 @default.
- W3201610942 hasRelatedWork W2920328542 @default.
- W3201610942 hasRelatedWork W4311106896 @default.
- W3201610942 isParatext "false" @default.
- W3201610942 isRetracted "false" @default.
- W3201610942 magId "3201610942" @default.
- W3201610942 workType "article" @default.