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• W3201611370 abstract "Green marine macroalgae, particularly Ulva lactuca, is an essential constituent of the cuisines in many Asian countries. The present work aims to separate a bioactive pyrone attached benzochromene analogue, named as ulvapyrone from the organic extract of U. lactuca, followed by its structural characterisation as 2-{(6a'-hydroxyethyl-4'-methyltetrahydro-2H-pyran-2'-one)-6'-yl}-4-methyl-7-ethylacetate-8-hydroxy-7, 8-dihydrobenzo [de]chromene. Ulvapyrone exhibited prospective inhibition property against arachidonate 5-lipoxygenase (IC50 ∼1 mg mL-1) comparable to that demonstrated by ibuprofen (IC50 0.9 mg mL-1), which connoted its anti-inflammatory activity. The studied benzochromene exhibited promising antioxidant potential (IC50 0.5-0.6 mg mL-1), which further reinforced its attenuation property against 5-lipoxygenase. Bioactivities of ulvapyrone were linearly correlated with electronic parameter (topological polar surface area ∼102) along with less binding energy (-8.22 kcal mol-1) with the allosteric site of 5-lipoxygenase. In silico predictions of physicochemical parameters along with absorption, distribution, metabolism and excretion could recognise the acceptable oral bioavailability of ulvapyrone." @default.
• W3201611370 created "2021-09-27" @default.
• W3201611370 creator A5019481850 @default.
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• W3201611370 date "2021-09-20" @default.
• W3201611370 modified "2023-09-24" @default.
• W3201611370 title "Ulvapyrone, a pyrone-linked benzochromene from sea lettuce <i>Ulva lactuca</i> Linnaeus (family Ulvaceae): newly described anti-inflammatory agent attenuates arachidonate 5-lipoxygenase" @default.
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• W3201611370 doi "https://doi.org/10.1080/14786419.2021.1976173" @default.
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