FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201612838> ?p ?o ?g. }

• W3201612838 abstract "Abstract Second-generation COVID-19 vaccines could contribute to establish protective immunity against SARS-CoV-2 and its emerging variants. We developed COH04S1, a synthetic multiantigen Modified Vaccinia Ankara-based SARS-CoV-2 vaccine that co-expresses spike and nucleocapsid antigens. Here, we report COH04S1 vaccine efficacy in animal models. We demonstrate that intramuscular or intranasal vaccination of Syrian hamsters with COH04S1 induces robust Th1-biased antigen-specific humoral immunity and cross-neutralizing antibodies (NAb) and protects against weight loss, lower respiratory tract infection, and lung injury following intranasal SARS-CoV-2 challenge. Moreover, we demonstrate that single-dose or two-dose vaccination of non-human primates with COH04S1 induces robust antigen-specific binding antibodies, NAb, and Th1-biased T cells, protects against both upper and lower respiratory tract infection following intranasal/intratracheal SARS-CoV-2 challenge, and triggers potent post-challenge anamnestic antiviral responses. These results demonstrate COH04S1-mediated vaccine protection in animal models through different vaccination routes and dose regimens, complementing ongoing investigation of this multiantigen SARS-CoV-2 vaccine in clinical trials." @default.
• W3201612838 created "2021-09-27" @default.
• W3201612838 creator A5006502427 @default.
• W3201612838 creator A5020064142 @default.
• W3201612838 creator A5022322002 @default.
• W3201612838 creator A5022693796 @default.
• W3201612838 creator A5032713428 @default.
• W3201612838 creator A5043325855 @default.
• W3201612838 creator A5043952477 @default.
• W3201612838 creator A5047813698 @default.
• W3201612838 creator A5048593024 @default.
• W3201612838 creator A5054200483 @default.
• W3201612838 creator A5054415390 @default.
• W3201612838 creator A5060102425 @default.
• W3201612838 creator A5063953420 @default.
• W3201612838 creator A5071894226 @default.
• W3201612838 creator A5072908565 @default.
• W3201612838 creator A5080946257 @default.
• W3201612838 creator A5082530695 @default.
• W3201612838 creator A5082853715 @default.
• W3201612838 creator A5087047108 @default.
• W3201612838 creator A5087524048 @default.
• W3201612838 creator A5087587511 @default.
• W3201612838 date "2021-09-15" @default.
• W3201612838 modified "2023-10-07" @default.
• W3201612838 title "Synthetic Multiantigen MVA Vaccine COH04S1 Protects Against SARS-CoV-2 in Syrian Hamsters and Non-Human Primates" @default.
• W3201612838 cites W1965971941 @default.
• W3201612838 cites W2065417495 @default.
• W3201612838 cites W2078685026 @default.
• W3201612838 cites W2080798548 @default.
• W3201612838 cites W2093619247 @default.
• W3201612838 cites W2216419812 @default.
• W3201612838 cites W2504828590 @default.
• W3201612838 cites W2537813141 @default.
• W3201612838 cites W2744960134 @default.
• W3201612838 cites W2884774134 @default.
• W3201612838 cites W2989502228 @default.
• W3201612838 cites W3001897055 @default.
• W3201612838 cites W3004280078 @default.
• W3201612838 cites W3005959611 @default.
• W3201612838 cites W3007643904 @default.
• W3201612838 cites W3009335299 @default.
• W3201612838 cites W3009912996 @default.
• W3201612838 cites W3012831148 @default.
• W3201612838 cites W3016653642 @default.
• W3201612838 cites W3016900702 @default.
• W3201612838 cites W3020828664 @default.
• W3201612838 cites W3021544284 @default.
• W3201612838 cites W3023230016 @default.
• W3201612838 cites W3025271273 @default.
• W3201612838 cites W3025320502 @default.
• W3201612838 cites W3025871232 @default.
• W3201612838 cites W3026558549 @default.
• W3201612838 cites W3027204812 @default.
• W3201612838 cites W3034680516 @default.
• W3201612838 cites W3035051352 @default.
• W3201612838 cites W3036887118 @default.
• W3201612838 cites W3045724532 @default.
• W3201612838 cites W3046061621 @default.
• W3201612838 cites W3063915832 @default.
• W3201612838 cites W3080724843 @default.
• W3201612838 cites W3081741393 @default.
• W3201612838 cites W3082438395 @default.
• W3201612838 cites W3087924281 @default.
• W3201612838 cites W3107299767 @default.
• W3201612838 cites W3108193091 @default.
• W3201612838 cites W3108252585 @default.
• W3201612838 cites W3109457440 @default.
• W3201612838 cites W3111255098 @default.
• W3201612838 cites W3111426898 @default.
• W3201612838 cites W3111590711 @default.
• W3201612838 cites W3120929353 @default.
• W3201612838 cites W3123664835 @default.
• W3201612838 cites W3126657865 @default.
• W3201612838 cites W3127329393 @default.
• W3201612838 cites W3127836986 @default.
• W3201612838 cites W3131995220 @default.
• W3201612838 cites W3134749657 @default.
• W3201612838 cites W3135383916 @default.
• W3201612838 cites W3139533040 @default.
• W3201612838 cites W3142246475 @default.
• W3201612838 cites W3153040293 @default.
• W3201612838 cites W3153508314 @default.
• W3201612838 cites W3156343712 @default.
• W3201612838 cites W3160306376 @default.
• W3201612838 cites W3164208781 @default.
• W3201612838 cites W3165367963 @default.
• W3201612838 cites W3168349393 @default.
• W3201612838 cites W3175747586 @default.
• W3201612838 cites W3175923549 @default.
• W3201612838 cites W3186329587 @default.
• W3201612838 cites W3195795781 @default.
• W3201612838 cites W4205483821 @default.
• W3201612838 cites W4211200665 @default.
• W3201612838 doi "https://doi.org/10.1101/2021.09.15.460487" @default.
• W3201612838 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8452095" @default.
• W3201612838 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34545366" @default.
• W3201612838 hasPublicationYear "2021" @default.
• W3201612838 type Work @default.
• W3201612838 sameAs 3201612838 @default.

• next