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- W3201620074 abstract "Abstract Purpose This study aimed to evaluate the potential synergistic role of three-dimensional power Doppler angiography ultrasound and the expression of Leukemia Inhibitory factor (LIF) protein in predicting the endometrial receptivity of fresh In Vitro Fertilization (IVF) cycles. Materials and methods This prospective study involved 29 good prognosis women who underwent fresh IVF cycles with fresh blastocysts transfer. Serial measurements of sub-endometrial parameters via power Doppler angiography including vascularity index (VI), flow index (FI), and vascularization flow index (VFI) were conducted consecutively on the day of oocyte maturation trigger, ovum pick-up, and blastocyst transfer. Aspiration of endometrial secretion was performed on the day of embryo transfer. Results After performing multiple logistic regression analyses, the mean index of VI on the trigger day and LIF protein concentration at the window of implantation was significantly higher in clinically pregnant women than that of the non-pregnant women ( p <0.05). The area under the curve (AUC) of LIF concentration was shown to have a powerful predictive value to forecast clinical pregnancy (0.884, p <0.05), with a cut-off value of 713 pg/mL. Likewise, VI index on the trigger day was adequate to become a predictor for the pregnancy event (AUC 0.803, the cut-off value >5.381, p <0.05). A combination of both variables utilizing the cut-off value was adequate for the differentiation of pregnant and non-pregnant cases ( p <0.05). Conclusion VI index assessed on trigger day and the expression of LIF protein concentration at the window of implantation provided sufficient information to predict endometrial receptivity." @default.
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- W3201620074 date "2021-09-17" @default.
- W3201620074 modified "2023-09-27" @default.
- W3201620074 title "Role of Three Dimensional Doppler Ultrasonography And Leukemia Inhibitory Factor From Endometrial Secretion In Predicting Clinical Pregnancy In IVF Treatment" @default.
- W3201620074 doi "https://doi.org/10.21203/rs.3.rs-831597/v1" @default.
- W3201620074 hasPublicationYear "2021" @default.
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