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- W3201626232 abstract "Abstract Poly(ethylene glycol) (PEG)‐glycosaminoglycan (GAG) hydrogel networks are established as very versatile biomaterials. Herein, the synthetic gel component of the biohybrid materials is systematically varied by combining different poly(2‐alkyl‐2‐oxazolines) (POx) with heparin applying a Michael‐type addition crosslinking scheme: POx of gradated hydrophilicity and temperature‐responsiveness provides polymer networks of distinctly different stiffness and swelling. Adjusting the mechanical properties and the GAG concentration of the gels to similar values allows for modulating the release of GAG‐binding growth factors (VEGF165 and PDGF‐BB) by the choice of the POx and its temperature‐dependent conformation. Adsorption of fibronectin, growth of fibroblasts, and bacterial adhesion scale with the hydrophobicity of the gel‐incorporated POx. In vitro hemocompatibility tests with freshly drawn human whole blood show advantages of POx‐based gels compared to the PEG‐based reference materials. Biohybrid POx hydrogels can therefore enable biomedical technologies requiring GAG‐based materials with customized and switchable physicochemical characteristics." @default.
- W3201626232 created "2021-09-27" @default.
- W3201626232 creator A5015920322 @default.
- W3201626232 creator A5024437898 @default.
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- W3201626232 creator A5084119399 @default.
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- W3201626232 creator A5089586331 @default.
- W3201626232 date "2021-09-20" @default.
- W3201626232 modified "2023-09-27" @default.
- W3201626232 title "Poly(2‐alkyl‐2‐oxazoline)‐Heparin Hydrogels—Expanding the Physicochemical Parameter Space of Biohybrid Materials" @default.
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