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- W3201634768 abstract "Allogenic hematopoietic stem cell transplantation (allo-HSCT) is one of the standard treatments for B-cell lymphoproliferative disorders; however, deep relapses are common after an allo-HSCT, and it is associated with poor prognosis. A successful approach to overcome these relapses is to exploit the body’s own immune system with chimeric antigen receptor (CAR) T-cells. These two approaches are potentially combinatorial for treating R/R B-cell lymphoproliferative disorders. Several clinical trials have described different scenarios in which allo-HSCT and CAR-T are successively combined. Further, for all transplanted patients, assessment of chimerism is important to evaluate the engraftment success. Nonetheless, for those patients who previously received an allo-HSCT there is no monitorization of chimerism before manufacturing CAR T-cells. In this review, we focus on allo-HSCT and CAR-T treatments and the different sources of T-cells for manufacturing CAR T-cells." @default.
- W3201634768 created "2021-09-27" @default.
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- W3201634768 date "2021-09-17" @default.
- W3201634768 modified "2023-10-18" @default.
- W3201634768 title "CAR-T after Stem Cell Transplantation in B-Cell Lymphoproliferative Disorders: Are They Really Autologous or Allogenic Cell Therapies?" @default.
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- W3201634768 doi "https://doi.org/10.3390/cancers13184664" @default.
- W3201634768 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8470158" @default.
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- W3201634768 hasPublicationYear "2021" @default.
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