FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201638812> ?p ?o ?g. }

• W3201638812 abstract "ABSTRACT A central goal of evolutionary genetics in Caenorhabditis elegans is to understand the genetic basis of traits that contribute to adaptation and fitness. Genome-wide association (GWA) mappings scan the genome for individual genetic variants that are significantly correlated with phenotypic variation in a population, or quantitative trait loci (QTL). GWA mappings are a popular choice for quantitative genetic analyses because the QTL that are discovered segregate in natural populations. Despite numerous successful mapping experiments, the empirical performance of GWA mappings has not, to date, been formally evaluated for this species. We developed an open-source GWA mapping pipeline called NemaScan and used a simulation-based approach to provide benchmarks of mapping performance among wild C. elegans strains. Simulated trait heritability and complexity determined the spectrum of QTL detected by GWA mappings. Power to detect smaller-effect QTL increased with the number of strains sampled from the C. elegans Natural Diversity Resource (CeNDR). Population structure was a major driver of variation in GWA mapping performance, with populations shaped by recent selection exhibiting significantly lower false discovery rates than populations composed of more divergent strains. We also recapitulated previous GWA mappings of experimentally validated quantitative trait variants. Our simulation-based evaluation of GWA performance provides the community with critical context for pursuing quantitative genetic studies using CeNDR to elucidate the genetic basis of complex traits in C. elegans natural populations." @default.
• W3201638812 created "2021-09-27" @default.
• W3201638812 creator A5012522236 @default.
• W3201638812 creator A5013229927 @default.
• W3201638812 creator A5036128795 @default.
• W3201638812 creator A5078198741 @default.
• W3201638812 date "2021-09-11" @default.
• W3201638812 modified "2023-10-18" @default.
• W3201638812 title "Evaluating the power and limitations of genome-wide association mapping in <i>C. elegans</i>" @default.
• W3201638812 cites W1970726947 @default.
• W3201638812 cites W1976604752 @default.
• W3201638812 cites W1977097867 @default.
• W3201638812 cites W2033151532 @default.
• W3201638812 cites W2034742459 @default.
• W3201638812 cites W2037478113 @default.
• W3201638812 cites W2038489248 @default.
• W3201638812 cites W2059073891 @default.
• W3201638812 cites W2064013109 @default.
• W3201638812 cites W2081977302 @default.
• W3201638812 cites W2088486634 @default.
• W3201638812 cites W2096522979 @default.
• W3201638812 cites W2096837660 @default.
• W3201638812 cites W2098410253 @default.
• W3201638812 cites W2098919825 @default.
• W3201638812 cites W2102214912 @default.
• W3201638812 cites W2102218399 @default.
• W3201638812 cites W2109755785 @default.
• W3201638812 cites W2117925179 @default.
• W3201638812 cites W2127684760 @default.
• W3201638812 cites W2131354461 @default.
• W3201638812 cites W2136967659 @default.
• W3201638812 cites W2155286781 @default.
• W3201638812 cites W2158534900 @default.
• W3201638812 cites W2167315684 @default.
• W3201638812 cites W2503032676 @default.
• W3201638812 cites W2529350482 @default.
• W3201638812 cites W2611331868 @default.
• W3201638812 cites W2613576825 @default.
• W3201638812 cites W2622904710 @default.
• W3201638812 cites W2725988230 @default.
• W3201638812 cites W2735593947 @default.
• W3201638812 cites W2744417500 @default.
• W3201638812 cites W2932671560 @default.
• W3201638812 cites W2935729442 @default.
• W3201638812 cites W2949271737 @default.
• W3201638812 cites W2949417290 @default.
• W3201638812 cites W2950135831 @default.
• W3201638812 cites W2952013316 @default.
• W3201638812 cites W2953023027 @default.
• W3201638812 cites W2953249266 @default.
• W3201638812 cites W2968864844 @default.
• W3201638812 cites W2969700164 @default.
• W3201638812 cites W2974164773 @default.
• W3201638812 cites W2986206782 @default.
• W3201638812 cites W2991212521 @default.
• W3201638812 cites W2992150894 @default.
• W3201638812 cites W2998114427 @default.
• W3201638812 cites W3082773318 @default.
• W3201638812 cites W3093853446 @default.
• W3201638812 cites W3103384520 @default.
• W3201638812 cites W3124814412 @default.
• W3201638812 cites W3133001185 @default.
• W3201638812 cites W3138637898 @default.
• W3201638812 cites W3142233419 @default.
• W3201638812 cites W3172096945 @default.
• W3201638812 cites W3181865545 @default.
• W3201638812 doi "https://doi.org/10.1101/2021.09.09.459688" @default.
• W3201638812 hasPublicationYear "2021" @default.
• W3201638812 type Work @default.
• W3201638812 sameAs 3201638812 @default.
• W3201638812 citedByCount "4" @default.
• W3201638812 countsByYear W32016388122021 @default.
• W3201638812 countsByYear W32016388122022 @default.
• W3201638812 crossrefType "posted-content" @default.
• W3201638812 hasAuthorship W3201638812A5012522236 @default.
• W3201638812 hasAuthorship W3201638812A5013229927 @default.
• W3201638812 hasAuthorship W3201638812A5036128795 @default.
• W3201638812 hasAuthorship W3201638812A5078198741 @default.
• W3201638812 hasBestOaLocation W32016388121 @default.
• W3201638812 hasConcept C104317684 @default.
• W3201638812 hasConcept C106208931 @default.
• W3201638812 hasConcept C106934330 @default.
• W3201638812 hasConcept C119857082 @default.
• W3201638812 hasConcept C134443026 @default.
• W3201638812 hasConcept C135763542 @default.
• W3201638812 hasConcept C141231307 @default.
• W3201638812 hasConcept C144024400 @default.
• W3201638812 hasConcept C149923435 @default.
• W3201638812 hasConcept C151730666 @default.
• W3201638812 hasConcept C153209595 @default.
• W3201638812 hasConcept C161890455 @default.
• W3201638812 hasConcept C186413461 @default.
• W3201638812 hasConcept C199360897 @default.
• W3201638812 hasConcept C2779343474 @default.
• W3201638812 hasConcept C2908647359 @default.
• W3201638812 hasConcept C41008148 @default.
• W3201638812 hasConcept C54355233 @default.
• W3201638812 hasConcept C61727976 @default.
• W3201638812 hasConcept C70721500 @default.
• W3201638812 hasConcept C78458016 @default.

• next