Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201650504> ?p ?o ?g. }
- W3201650504 endingPage "646" @default.
- W3201650504 startingPage "646" @default.
- W3201650504 abstract "Lipid metabolism is tightly linked to adiposity. Comprehensive lipidomic profiling offers new insights into the dysregulation of lipid metabolism in relation to weight gain. Here, we investigated the relationship of the human plasma lipidome and changes in waist circumference (WC) and body mass index (BMI). Adults (2653 men and 3196 women), 25–95 years old who attended the baseline survey of the Australian Diabetes, Obesity and Lifestyle Study (AusDiab) and the 5-year follow-up were enrolled. A targeted lipidomic approach was used to quantify 706 distinct molecular lipid species in the plasma samples. Multiple linear regression models were used to examine the relationship between the baseline lipidomic profile and changes in WC and BMI. Metabolic scores for change in WC were generated using a ridge regression model. Alkyl-diacylglycerol such as TG(O-50:2) [NL-18:1] displayed the strongest association with change in WC (β-coefficient = 0.125 cm increment per SD increment in baseline lipid level, p = 2.78 × 10−11. Many lipid species containing linoleate (18:2) fatty acids were negatively associated with both WC and BMI gain. Compared to traditional models, multivariate models containing lipid species identify individuals at a greater risk of gaining WC: top quintile relative to bottom quintile (odds ratio, 95% CI = 5.4, 3.8–6.6 for women and 2.3, 1.7–3.0 for men). Our findings define metabolic profiles that characterize individuals at risk of weight gain or WC increase and provide important insight into the biological role of lipids in obesity." @default.
- W3201650504 created "2021-09-27" @default.
- W3201650504 creator A5010188514 @default.
- W3201650504 creator A5018096963 @default.
- W3201650504 creator A5024475260 @default.
- W3201650504 creator A5031677215 @default.
- W3201650504 creator A5036079859 @default.
- W3201650504 creator A5038367542 @default.
- W3201650504 creator A5046060573 @default.
- W3201650504 creator A5049270568 @default.
- W3201650504 creator A5079013516 @default.
- W3201650504 creator A5084735007 @default.
- W3201650504 date "2021-09-21" @default.
- W3201650504 modified "2023-10-02" @default.
- W3201650504 title "Lipidomic Signatures of Changes in Adiposity: A Large Prospective Study of 5849 Adults from the Australian Diabetes, Obesity and Lifestyle Study" @default.
- W3201650504 cites W1562491163 @default.
- W3201650504 cites W1570340380 @default.
- W3201650504 cites W1963756943 @default.
- W3201650504 cites W2003036441 @default.
- W3201650504 cites W2010768303 @default.
- W3201650504 cites W2043768621 @default.
- W3201650504 cites W2047193344 @default.
- W3201650504 cites W2052100877 @default.
- W3201650504 cites W2052335573 @default.
- W3201650504 cites W2060831873 @default.
- W3201650504 cites W2064612269 @default.
- W3201650504 cites W2069652505 @default.
- W3201650504 cites W2098993721 @default.
- W3201650504 cites W2104890139 @default.
- W3201650504 cites W2110065044 @default.
- W3201650504 cites W2117358660 @default.
- W3201650504 cites W2117968615 @default.
- W3201650504 cites W2119701413 @default.
- W3201650504 cites W2121599947 @default.
- W3201650504 cites W2125350334 @default.
- W3201650504 cites W2133581937 @default.
- W3201650504 cites W2154768987 @default.
- W3201650504 cites W2156335010 @default.
- W3201650504 cites W2157104515 @default.
- W3201650504 cites W2166913034 @default.
- W3201650504 cites W2167062509 @default.
- W3201650504 cites W2170417182 @default.
- W3201650504 cites W2170723132 @default.
- W3201650504 cites W2294316266 @default.
- W3201650504 cites W2486972204 @default.
- W3201650504 cites W2600037143 @default.
- W3201650504 cites W2751149214 @default.
- W3201650504 cites W2781143840 @default.
- W3201650504 cites W2794600219 @default.
- W3201650504 cites W2800550251 @default.
- W3201650504 cites W2807696312 @default.
- W3201650504 cites W2810263221 @default.
- W3201650504 cites W2895903553 @default.
- W3201650504 cites W2895911941 @default.
- W3201650504 cites W2901420681 @default.
- W3201650504 cites W2902122489 @default.
- W3201650504 cites W2914359073 @default.
- W3201650504 cites W2916737553 @default.
- W3201650504 cites W2944171922 @default.
- W3201650504 cites W2953007169 @default.
- W3201650504 cites W2978403869 @default.
- W3201650504 cites W2996245189 @default.
- W3201650504 cites W2998301974 @default.
- W3201650504 cites W3001564603 @default.
- W3201650504 cites W3004601926 @default.
- W3201650504 cites W3004876731 @default.
- W3201650504 cites W3006740333 @default.
- W3201650504 cites W3029472550 @default.
- W3201650504 cites W3039267034 @default.
- W3201650504 cites W3088813603 @default.
- W3201650504 cites W3091279222 @default.
- W3201650504 doi "https://doi.org/10.3390/metabo11090646" @default.
- W3201650504 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8471381" @default.
- W3201650504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34564462" @default.
- W3201650504 hasPublicationYear "2021" @default.
- W3201650504 type Work @default.
- W3201650504 sameAs 3201650504 @default.
- W3201650504 citedByCount "9" @default.
- W3201650504 countsByYear W32016505042022 @default.
- W3201650504 countsByYear W32016505042023 @default.
- W3201650504 crossrefType "journal-article" @default.
- W3201650504 hasAuthorship W3201650504A5010188514 @default.
- W3201650504 hasAuthorship W3201650504A5018096963 @default.
- W3201650504 hasAuthorship W3201650504A5024475260 @default.
- W3201650504 hasAuthorship W3201650504A5031677215 @default.
- W3201650504 hasAuthorship W3201650504A5036079859 @default.
- W3201650504 hasAuthorship W3201650504A5038367542 @default.
- W3201650504 hasAuthorship W3201650504A5046060573 @default.
- W3201650504 hasAuthorship W3201650504A5049270568 @default.
- W3201650504 hasAuthorship W3201650504A5079013516 @default.
- W3201650504 hasAuthorship W3201650504A5084735007 @default.
- W3201650504 hasBestOaLocation W32016505041 @default.
- W3201650504 hasConcept C126322002 @default.
- W3201650504 hasConcept C134018914 @default.
- W3201650504 hasConcept C2776193436 @default.
- W3201650504 hasConcept C2778270857 @default.
- W3201650504 hasConcept C2780221984 @default.
- W3201650504 hasConcept C2780241833 @default.