Matches in SemOpenAlex for { <https://semopenalex.org/work/W3201655315> ?p ?o ?g. }
- W3201655315 endingPage "848.e1" @default.
- W3201655315 startingPage "841" @default.
- W3201655315 abstract "Equations for estimated glomerular filtration rate (eGFR) that incorporate a term for race assign a higher value to Black individuals compared to non-Black individuals for the same sex, age, and serum creatinine concentration. This difference may contribute to racial disparities in kidney transplant access. We sought to (1) compare time from meeting a transplant eligibility threshold of eGFR ≤20 mL/min/1.73 m2 to kidney failure with replacement therapy (KFRT) among Black, Hispanic, and White patients, and (2) assess the impact of incorporation of race into eGFR expressions on establishment of waitlist eligibility and time from eligibility to KFRT.Retrospective cohort.Using the OptumLabs Data Warehouse, we assembled a cohort of 40,042 White, 8,519 Black, and 3,569 Hispanic patients having at least one eGFR value between 20 and 60 mL/min/1.73 m2 within the preceding 2 years and an incident outpatient eGFR of ≤20 mL/min/1.73 m2 between 2008-2018, using the CKD-EPI creatinine equation that includes a term for race coded as Black or non-Black. We then reassembled a Black patient cohort based on incident eGFR ≤20 mL/min/1.73 m2 (n = 11,269) estimated using the same CKD-EPI equation but coding Black patients as non-Black.Race/ethnicity.Time to KFRT.Unadjusted and adjusted Fine-Gray models; linear regression to compute eGFR slopes.By 3 years, the cumulative incidence of KFRT was 20.5% among White patients, 40.9% among Hispanic patients, 36% among Black patients whose GFR was estimated using a race term coded as Black, and 28.7% among Black patients whose GFR was estimated using a race term coded as non-Black. In fully adjusted analyses including 11,269 Black patients with an eGFR ≤20 mL/min/1.73 m2 based on coding them as non-Black, KFRT risk remained greater among Black (HR, 1.28 [95% CI, 1.15-1.43]) and Hispanic (HR, 1.66 [95% CI, 1.18-2.31]) patients than among White patients. Based on slopes of eGFR decline, coding Black patients as non-Black would allow earlier waitlist activation by an estimated median of 0.5 [interquartile range, 0.27-1.23] years.Inability to exclude individuals who would not be kidney transplant candidates if comprehensively evaluated.A uniform eGFR threshold provides less opportunity for being placed on the transplant waitlist among Black and Hispanic patients. For many Black patients, estimation of GFR as if their race category were non-Black would allow substantially earlier waitlisting but would not eliminate their shorter time to KFRT and reduced opportunity for preemptive transplantation compared with White patients." @default.
- W3201655315 created "2021-09-27" @default.
- W3201655315 creator A5011495488 @default.
- W3201655315 creator A5050973509 @default.
- W3201655315 creator A5076142063 @default.
- W3201655315 creator A5091041938 @default.
- W3201655315 date "2022-06-01" @default.
- W3201655315 modified "2023-10-06" @default.
- W3201655315 title "CKD Progression From the Time of Estimated GFR-Based Waitlist Eligibility and Racial Disparities in Transplant Access" @default.
- W3201655315 cites W2002359955 @default.
- W3201655315 cites W2029697998 @default.
- W3201655315 cites W2038981426 @default.
- W3201655315 cites W2055864845 @default.
- W3201655315 cites W2057812882 @default.
- W3201655315 cites W2151072914 @default.
- W3201655315 cites W2155965977 @default.
- W3201655315 cites W2159099163 @default.
- W3201655315 cites W2165817472 @default.
- W3201655315 cites W2169946604 @default.
- W3201655315 cites W2170589488 @default.
- W3201655315 cites W2234357320 @default.
- W3201655315 cites W2320684363 @default.
- W3201655315 cites W2607031541 @default.
- W3201655315 cites W2731253005 @default.
- W3201655315 cites W2741868759 @default.
- W3201655315 cites W2789167483 @default.
- W3201655315 cites W2794869516 @default.
- W3201655315 cites W2886162684 @default.
- W3201655315 cites W2887874201 @default.
- W3201655315 cites W2920239764 @default.
- W3201655315 cites W2949004837 @default.
- W3201655315 cites W2968232135 @default.
- W3201655315 cites W3010763889 @default.
- W3201655315 cites W3046113390 @default.
- W3201655315 cites W3046321541 @default.
- W3201655315 cites W3092668967 @default.
- W3201655315 cites W3097950417 @default.
- W3201655315 cites W3120555749 @default.
- W3201655315 cites W3121110988 @default.
- W3201655315 cites W3129275323 @default.
- W3201655315 cites W3132650396 @default.
- W3201655315 cites W3134566315 @default.
- W3201655315 cites W3179827115 @default.
- W3201655315 cites W2324808355 @default.
- W3201655315 doi "https://doi.org/10.1053/j.ajkd.2021.08.010" @default.
- W3201655315 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34543686" @default.
- W3201655315 hasPublicationYear "2022" @default.
- W3201655315 type Work @default.
- W3201655315 sameAs 3201655315 @default.
- W3201655315 citedByCount "5" @default.
- W3201655315 countsByYear W32016553152022 @default.
- W3201655315 countsByYear W32016553152023 @default.
- W3201655315 crossrefType "journal-article" @default.
- W3201655315 hasAuthorship W3201655315A5011495488 @default.
- W3201655315 hasAuthorship W3201655315A5050973509 @default.
- W3201655315 hasAuthorship W3201655315A5076142063 @default.
- W3201655315 hasAuthorship W3201655315A5091041938 @default.
- W3201655315 hasBestOaLocation W32016553152 @default.
- W3201655315 hasConcept C126322002 @default.
- W3201655315 hasConcept C126894567 @default.
- W3201655315 hasConcept C159641895 @default.
- W3201655315 hasConcept C167135981 @default.
- W3201655315 hasConcept C2778653478 @default.
- W3201655315 hasConcept C2780303639 @default.
- W3201655315 hasConcept C2780306776 @default.
- W3201655315 hasConcept C2911091166 @default.
- W3201655315 hasConcept C2994498544 @default.
- W3201655315 hasConcept C71924100 @default.
- W3201655315 hasConcept C72563966 @default.
- W3201655315 hasConceptScore W3201655315C126322002 @default.
- W3201655315 hasConceptScore W3201655315C126894567 @default.
- W3201655315 hasConceptScore W3201655315C159641895 @default.
- W3201655315 hasConceptScore W3201655315C167135981 @default.
- W3201655315 hasConceptScore W3201655315C2778653478 @default.
- W3201655315 hasConceptScore W3201655315C2780303639 @default.
- W3201655315 hasConceptScore W3201655315C2780306776 @default.
- W3201655315 hasConceptScore W3201655315C2911091166 @default.
- W3201655315 hasConceptScore W3201655315C2994498544 @default.
- W3201655315 hasConceptScore W3201655315C71924100 @default.
- W3201655315 hasConceptScore W3201655315C72563966 @default.
- W3201655315 hasFunder F4320311255 @default.
- W3201655315 hasFunder F4320332161 @default.
- W3201655315 hasFunder F4320337357 @default.
- W3201655315 hasIssue "6" @default.
- W3201655315 hasLocation W32016553151 @default.
- W3201655315 hasLocation W32016553152 @default.
- W3201655315 hasLocation W32016553153 @default.
- W3201655315 hasOpenAccess W3201655315 @default.
- W3201655315 hasPrimaryLocation W32016553151 @default.
- W3201655315 hasRelatedWork W1564222293 @default.
- W3201655315 hasRelatedWork W1948603161 @default.
- W3201655315 hasRelatedWork W2022369832 @default.
- W3201655315 hasRelatedWork W2050789305 @default.
- W3201655315 hasRelatedWork W2313598751 @default.
- W3201655315 hasRelatedWork W2387860588 @default.
- W3201655315 hasRelatedWork W2411849704 @default.
- W3201655315 hasRelatedWork W2909812024 @default.
- W3201655315 hasRelatedWork W393698729 @default.